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- Publisher Website: 10.1038/bjc.1981.60
- Scopus: eid_2-s2.0-0019449063
- PMID: 7225288
- WOS: WOS:A1981LK02700019
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Article: Some mechanisms of local bone destruction by squamous carcinomas of the head and neck
Title | Some mechanisms of local bone destruction by squamous carcinomas of the head and neck |
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Authors | |
Issue Date | 1981 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc |
Citation | British Journal Of Cancer, 1981, v. 43 n. 3, p. 392-401 How to Cite? |
Abstract | An in vitro osteolysis assay with 45 Ca-labelled mouse calvaria has been used to investigate mechanisms of direct bone invasion by squamous carcinomas of the head and neck. Short-term (3-day) organ cultures of 8 fresh squamous carcinomas showed varying degrees of in vitro bone-resorbing activity which was blocked by indomethacin, an inhibitor of prostaglandin synthesis. Supernatant media from 6 established cell lines also induced bone resorption in vitro and evoked an osteoclastic response in the cultured calvaria. Osteolysis by supernatant media was not blocked by indomethacin in all the tumour-cell lines, and the production of non-prostaglandin osteolysins by the indomethacin-resistant lines is postulated. The two principal findings that emerge are: Stimulants for osteoclastic activity are derived from both squamous-carcinoma cells and from host cells in the tumour stroma. These stimulants are diverse. Indomethacin-sensitive agents, presumed to be prostaglandins, are most convincingly demonstrated in the fresh tumours. Indomethacin-resistant agents, presumably not prostaglandins, are more characteristic of the carcinoma cell lines. |
Persistent Identifier | http://hdl.handle.net/10722/149427 |
ISSN | 2021 Impact Factor: 9.075 2020 SCImago Journal Rankings: 2.833 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsao, SW | en_US |
dc.contributor.author | Burman, JF | en_US |
dc.contributor.author | Easty, DM | en_US |
dc.date.accessioned | 2012-06-26T05:53:34Z | - |
dc.date.available | 2012-06-26T05:53:34Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | British Journal Of Cancer, 1981, v. 43 n. 3, p. 392-401 | en_US |
dc.identifier.issn | 0007-0920 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149427 | - |
dc.description.abstract | An in vitro osteolysis assay with 45 Ca-labelled mouse calvaria has been used to investigate mechanisms of direct bone invasion by squamous carcinomas of the head and neck. Short-term (3-day) organ cultures of 8 fresh squamous carcinomas showed varying degrees of in vitro bone-resorbing activity which was blocked by indomethacin, an inhibitor of prostaglandin synthesis. Supernatant media from 6 established cell lines also induced bone resorption in vitro and evoked an osteoclastic response in the cultured calvaria. Osteolysis by supernatant media was not blocked by indomethacin in all the tumour-cell lines, and the production of non-prostaglandin osteolysins by the indomethacin-resistant lines is postulated. The two principal findings that emerge are: Stimulants for osteoclastic activity are derived from both squamous-carcinoma cells and from host cells in the tumour stroma. These stimulants are diverse. Indomethacin-sensitive agents, presumed to be prostaglandins, are most convincingly demonstrated in the fresh tumours. Indomethacin-resistant agents, presumably not prostaglandins, are more characteristic of the carcinoma cell lines. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc | en_US |
dc.relation.ispartof | British Journal of Cancer | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bone Resorption - Drug Effects | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Pathology - Physiopathology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Head And Neck Neoplasms - Pathology - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Organ Culture Techniques | en_US |
dc.subject.mesh | Osteolysis | en_US |
dc.title | Some mechanisms of local bone destruction by squamous carcinomas of the head and neck | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_US |
dc.identifier.authority | Tsao, SW=rp00399 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/bjc.1981.60 | - |
dc.identifier.pmid | 7225288 | - |
dc.identifier.scopus | eid_2-s2.0-0019449063 | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 392 | en_US |
dc.identifier.epage | 401 | en_US |
dc.identifier.isi | WOS:A1981LK02700019 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_US |
dc.identifier.scopusauthorid | Burman, JF=16159916300 | en_US |
dc.identifier.scopusauthorid | Easty, DM=7101936257 | en_US |
dc.identifier.issnl | 0007-0920 | - |