File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Some mechanisms of local bone destruction by squamous carcinomas of the head and neck

TitleSome mechanisms of local bone destruction by squamous carcinomas of the head and neck
Authors
Issue Date1981
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 1981, v. 43 n. 3, p. 392-401 How to Cite?
AbstractAn in vitro osteolysis assay with 45 Ca-labelled mouse calvaria has been used to investigate mechanisms of direct bone invasion by squamous carcinomas of the head and neck. Short-term (3-day) organ cultures of 8 fresh squamous carcinomas showed varying degrees of in vitro bone-resorbing activity which was blocked by indomethacin, an inhibitor of prostaglandin synthesis. Supernatant media from 6 established cell lines also induced bone resorption in vitro and evoked an osteoclastic response in the cultured calvaria. Osteolysis by supernatant media was not blocked by indomethacin in all the tumour-cell lines, and the production of non-prostaglandin osteolysins by the indomethacin-resistant lines is postulated. The two principal findings that emerge are: Stimulants for osteoclastic activity are derived from both squamous-carcinoma cells and from host cells in the tumour stroma. These stimulants are diverse. Indomethacin-sensitive agents, presumed to be prostaglandins, are most convincingly demonstrated in the fresh tumours. Indomethacin-resistant agents, presumably not prostaglandins, are more characteristic of the carcinoma cell lines.
Persistent Identifierhttp://hdl.handle.net/10722/149427
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_US
dc.contributor.authorBurman, JFen_US
dc.contributor.authorEasty, DMen_US
dc.date.accessioned2012-06-26T05:53:34Z-
dc.date.available2012-06-26T05:53:34Z-
dc.date.issued1981en_US
dc.identifier.citationBritish Journal Of Cancer, 1981, v. 43 n. 3, p. 392-401en_US
dc.identifier.issn0007-0920en_US
dc.identifier.urihttp://hdl.handle.net/10722/149427-
dc.description.abstractAn in vitro osteolysis assay with 45 Ca-labelled mouse calvaria has been used to investigate mechanisms of direct bone invasion by squamous carcinomas of the head and neck. Short-term (3-day) organ cultures of 8 fresh squamous carcinomas showed varying degrees of in vitro bone-resorbing activity which was blocked by indomethacin, an inhibitor of prostaglandin synthesis. Supernatant media from 6 established cell lines also induced bone resorption in vitro and evoked an osteoclastic response in the cultured calvaria. Osteolysis by supernatant media was not blocked by indomethacin in all the tumour-cell lines, and the production of non-prostaglandin osteolysins by the indomethacin-resistant lines is postulated. The two principal findings that emerge are: Stimulants for osteoclastic activity are derived from both squamous-carcinoma cells and from host cells in the tumour stroma. These stimulants are diverse. Indomethacin-sensitive agents, presumed to be prostaglandins, are most convincingly demonstrated in the fresh tumours. Indomethacin-resistant agents, presumably not prostaglandins, are more characteristic of the carcinoma cell lines.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_US
dc.relation.ispartofBritish Journal of Canceren_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Resorption - Drug Effectsen_US
dc.subject.meshCarcinoma, Squamous Cell - Pathology - Physiopathologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshFemaleen_US
dc.subject.meshHead And Neck Neoplasms - Pathology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshOsteolysisen_US
dc.titleSome mechanisms of local bone destruction by squamous carcinomas of the head and necken_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7225288-
dc.identifier.scopuseid_2-s2.0-0019449063en_US
dc.identifier.volume43en_US
dc.identifier.issue3en_US
dc.identifier.spage392en_US
dc.identifier.epage401en_US
dc.identifier.isiWOS:A1981LK02700019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridBurman, JF=16159916300en_US
dc.identifier.scopusauthoridEasty, DM=7101936257en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats