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Article: Regeneration of an abnormal ipsilateral visuotectal projection in Xenopus is delayed by the presence of optic fibers from the other eye

TitleRegeneration of an abnormal ipsilateral visuotectal projection in Xenopus is delayed by the presence of optic fibers from the other eye
Authors
Issue Date1980
Citation
Journal Of Embryology And Experimental Morphology, 1980, v. VOL.57, p. 129-141 How to Cite?
AbstractOptic fiber regeneration was studied by [3H]proline autoradiography and by mapping electrophysiologically the direct visuotectal projections to the contralateral and ipsilateral tecta 12-16 wk after sectioning the right optic nerve in Xenopus 2 to 4 wk after metamorphosis. The experiments were carried out in 3 groups: (A) optic nerve section in newly metamorphosed animals with embryonic left-eye enucleation; (B) optic nerve section with simultaneous left-eye enucleation; and (C) optic nerve section with delayed left-eye enucleation 5-31 days prior to sacrifice. In all but 3 animals regenerated optic fibers were demonstrated morphologically both in the contralateral and ipsilateral tecta. The contralateral visuotectal projection was fully restored within the 12-16 wk in all animals. In animals with embryonic enucleation or in those where the enucleation was carried out simultaneously with optic nerve section, a direct ipsilateral visuotectal projection was established at the same time as the restoration of the contralateral projection. In contrast, no direct ipsilateral visuotectal projection was detectable in the presence of optic fibers from the other eye in the doubly innervated tecta. However, 14-31 days after the removal of the incumbent optic fibers by left-eye enucleation a direct visuotectal projection from the right eye to the ipsilateral tectum was established, and its polarity corresponded to the normal contralateral retinotectal projection. The apparent disparity between morphological and electrophysiological findings in the doubly innervated tectum suggests that superimposed optic fibers are unable to form normal synaptic relations with tectal neurons during early regeneration, delaying the establishment of the induced direct ipsilateral visuotectal projection.
Persistent Identifierhttp://hdl.handle.net/10722/149421
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStraznicky, Cen_US
dc.contributor.authorTay, Den_US
dc.contributor.authorGlastonbury, Jen_US
dc.date.accessioned2012-06-26T05:53:30Z-
dc.date.available2012-06-26T05:53:30Z-
dc.date.issued1980en_US
dc.identifier.citationJournal Of Embryology And Experimental Morphology, 1980, v. VOL.57, p. 129-141en_US
dc.identifier.issn0022-0752en_US
dc.identifier.urihttp://hdl.handle.net/10722/149421-
dc.description.abstractOptic fiber regeneration was studied by [3H]proline autoradiography and by mapping electrophysiologically the direct visuotectal projections to the contralateral and ipsilateral tecta 12-16 wk after sectioning the right optic nerve in Xenopus 2 to 4 wk after metamorphosis. The experiments were carried out in 3 groups: (A) optic nerve section in newly metamorphosed animals with embryonic left-eye enucleation; (B) optic nerve section with simultaneous left-eye enucleation; and (C) optic nerve section with delayed left-eye enucleation 5-31 days prior to sacrifice. In all but 3 animals regenerated optic fibers were demonstrated morphologically both in the contralateral and ipsilateral tecta. The contralateral visuotectal projection was fully restored within the 12-16 wk in all animals. In animals with embryonic enucleation or in those where the enucleation was carried out simultaneously with optic nerve section, a direct ipsilateral visuotectal projection was established at the same time as the restoration of the contralateral projection. In contrast, no direct ipsilateral visuotectal projection was detectable in the presence of optic fibers from the other eye in the doubly innervated tecta. However, 14-31 days after the removal of the incumbent optic fibers by left-eye enucleation a direct visuotectal projection from the right eye to the ipsilateral tectum was established, and its polarity corresponded to the normal contralateral retinotectal projection. The apparent disparity between morphological and electrophysiological findings in the doubly innervated tectum suggests that superimposed optic fibers are unable to form normal synaptic relations with tectal neurons during early regeneration, delaying the establishment of the induced direct ipsilateral visuotectal projection.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Embryology and Experimental Morphologyen_US
dc.subject.meshAction Potentialsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshNerve Fibers - Physiologyen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshOptic Nerve - Physiologyen_US
dc.subject.meshRetina - Physiologyen_US
dc.subject.meshSuperior Colliculi - Physiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVisual Pathways - Physiologyen_US
dc.subject.meshXenopus Laevisen_US
dc.titleRegeneration of an abnormal ipsilateral visuotectal projection in Xenopus is delayed by the presence of optic fibers from the other eyeen_US
dc.typeArticleen_US
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_US
dc.identifier.authorityTay, D=rp00336en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7430926en_US
dc.identifier.scopuseid_2-s2.0-0018828819en_US
dc.identifier.volumeVOL.57en_US
dc.identifier.spage129en_US
dc.identifier.epage141en_US
dc.identifier.isiWOS:A1980KB22800011-
dc.identifier.scopusauthoridStraznicky, C=7004293883en_US
dc.identifier.scopusauthoridTay, D=7006796825en_US
dc.identifier.scopusauthoridGlastonbury, J=7004612892en_US

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