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Article: Postnatal development of retinal projections in Syrian hamsters: A study using autoradiographic and anterograde degeneration techniques

TitlePostnatal development of retinal projections in Syrian hamsters: A study using autoradiographic and anterograde degeneration techniques
Authors
Issue Date1979
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 1979, v. 4 n. 11, p. 1649-1677 How to Cite?
AbstractIn the Syrian hamster, there is a delay between the laying down of the trajectory of the optic tract (principally a prenatal event) and the formation by the optic tract of its various dense terminal projections (principally a postnatal event): At birth (Day 0), crossed retinofugal axons already cover the lateral geniculate body and extend into the superior colliculus. Although pioneering retinal efferents enter their target nuclei before Day 3, robust development of retinofugal axon telodendria is apparently delayed until that date; the onset of this arborization occurs simultaneously in the lateral geniculate body and superior colliculus even though the axons of the optic tract pass over the lateral geniculate body before they arrive in the superior colliculus. In all structures receiving binocular projections except the suprachiasmatic nucleus the development of uncrossed optic tract axons lags behind the development of the crossed axons. In regions where optic tract axons terminate in precise retinotopic order, the projections of the two eyes are segregated in adult animals, and the definitive patterns of connection develop gradually from less differential patterns: In the dorsal nucleus of the lateral geniculate body, crossed optic tract axons initially fill the entire nucleus overlapping with the uncrossed axons; subsequently they withdraw from the ipsilateral projection zone, as the terminal distributions of uncrossed axons increase in density and volume. In adult hamsters, much of the uncrossed retinal input to the superior colliculus is distributed in multiple discrete clusters. Initially the clusters are not present, but develop gradually from a more diffuse pattern. Since the adult distributions of crossed and uncrossed retinofugal projections are established before the time when the eyes open (Day 14), the factors which determine these distributions appear to be independent of exposure to patterned visual input. In neonatal hamsters, as in adults, different populations of retinofugal axons may be distinguished by their differential rates degeneration. (6) Some of the developmental changes in the hamster's retinal projections are similar to ontogenetic phenomena reported for other populations of central and peripheral axons.
Persistent Identifierhttp://hdl.handle.net/10722/149419
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFrost, DOen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorSchneider, GEen_US
dc.date.accessioned2012-06-26T05:53:29Z-
dc.date.available2012-06-26T05:53:29Z-
dc.date.issued1979en_US
dc.identifier.citationNeuroscience, 1979, v. 4 n. 11, p. 1649-1677en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/149419-
dc.description.abstractIn the Syrian hamster, there is a delay between the laying down of the trajectory of the optic tract (principally a prenatal event) and the formation by the optic tract of its various dense terminal projections (principally a postnatal event): At birth (Day 0), crossed retinofugal axons already cover the lateral geniculate body and extend into the superior colliculus. Although pioneering retinal efferents enter their target nuclei before Day 3, robust development of retinofugal axon telodendria is apparently delayed until that date; the onset of this arborization occurs simultaneously in the lateral geniculate body and superior colliculus even though the axons of the optic tract pass over the lateral geniculate body before they arrive in the superior colliculus. In all structures receiving binocular projections except the suprachiasmatic nucleus the development of uncrossed optic tract axons lags behind the development of the crossed axons. In regions where optic tract axons terminate in precise retinotopic order, the projections of the two eyes are segregated in adult animals, and the definitive patterns of connection develop gradually from less differential patterns: In the dorsal nucleus of the lateral geniculate body, crossed optic tract axons initially fill the entire nucleus overlapping with the uncrossed axons; subsequently they withdraw from the ipsilateral projection zone, as the terminal distributions of uncrossed axons increase in density and volume. In adult hamsters, much of the uncrossed retinal input to the superior colliculus is distributed in multiple discrete clusters. Initially the clusters are not present, but develop gradually from a more diffuse pattern. Since the adult distributions of crossed and uncrossed retinofugal projections are established before the time when the eyes open (Day 14), the factors which determine these distributions appear to be independent of exposure to patterned visual input. In neonatal hamsters, as in adults, different populations of retinofugal axons may be distinguished by their differential rates degeneration. (6) Some of the developmental changes in the hamster's retinal projections are similar to ontogenetic phenomena reported for other populations of central and peripheral axons.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.subject.meshAgingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshAxons - Physiologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshGeniculate Bodies - Growth & Developmenten_US
dc.subject.meshMesocricetusen_US
dc.subject.meshOcular Physiological Phenomenaen_US
dc.subject.meshOptic Nerve - Growth & Developmenten_US
dc.subject.meshRetina - Growth & Developmenten_US
dc.titlePostnatal development of retinal projections in Syrian hamsters: A study using autoradiographic and anterograde degeneration techniquesen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-4522(79)90026-5en_US
dc.identifier.pmid514512-
dc.identifier.scopuseid_2-s2.0-0018635010en_US
dc.identifier.volume4en_US
dc.identifier.issue11en_US
dc.identifier.spage1649en_US
dc.identifier.epage1677en_US
dc.identifier.isiWOS:A1979HV34800010-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFrost, DO=7101949548en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridSchneider, GE=55057824300en_US

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