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Article: Abnormal recrossing retinotectal projections after early lesions in Syrian hamsters: age-related effects

TitleAbnormal recrossing retinotectal projections after early lesions in Syrian hamsters: age-related effects
Authors
Issue Date1978
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1978, v. 147 n. 2, p. 277-295 How to Cite?
AbstractIf the superficial layers of the right superior colliculus (SC) of a newborn hamster are removed, fibers from the left eye not only terminate in the surviving deeper layers of the right SC, but also cross the tectal midline and terminate in the medial third of the left SC. If the right eye is also removed at birth, the abnormally recrossing fibers from the left eye will spread over the entire surface of the left SC. In this series of experiments, we ablated the right SC of hamsters at birth, but enucleated the right eye on different days postnatally in order to examine the spreading of the axon terminal pattern as a function of age. When the animals were young adults, the pattern of retinofugal projection of the left eye was traced using the Fink-Heimer technique or with autoradiography. It was found that the projections from the left eye continue to spread over the entire left SC when the right eye was removed up until day 10, though their distribution was more sparse when the eye was removed on days 7-10 than when it was removed on days 0-6. When the removal of the right eye was delayed until day 12, the lateral spreading of recrossing axons was markedly reduced. When the right eye was removed on day 14, the distribution of the projections from the left eye was restricted to the medial third of the left SC, just as if no early eye removal had been performed. It appears that after a critical age is reached, even when terminal space is available the axons and axon terminals will not move, at least not over any appreciable distance.
Persistent Identifierhttp://hdl.handle.net/10722/149410
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_US
dc.contributor.authorSchneider, GEen_US
dc.date.accessioned2012-06-26T05:53:22Z-
dc.date.available2012-06-26T05:53:22Z-
dc.date.issued1978en_US
dc.identifier.citationBrain Research, 1978, v. 147 n. 2, p. 277-295en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149410-
dc.description.abstractIf the superficial layers of the right superior colliculus (SC) of a newborn hamster are removed, fibers from the left eye not only terminate in the surviving deeper layers of the right SC, but also cross the tectal midline and terminate in the medial third of the left SC. If the right eye is also removed at birth, the abnormally recrossing fibers from the left eye will spread over the entire surface of the left SC. In this series of experiments, we ablated the right SC of hamsters at birth, but enucleated the right eye on different days postnatally in order to examine the spreading of the axon terminal pattern as a function of age. When the animals were young adults, the pattern of retinofugal projection of the left eye was traced using the Fink-Heimer technique or with autoradiography. It was found that the projections from the left eye continue to spread over the entire left SC when the right eye was removed up until day 10, though their distribution was more sparse when the eye was removed on days 7-10 than when it was removed on days 0-6. When the removal of the right eye was delayed until day 12, the lateral spreading of recrossing axons was markedly reduced. When the right eye was removed on day 14, the distribution of the projections from the left eye was restricted to the medial third of the left SC, just as if no early eye removal had been performed. It appears that after a critical age is reached, even when terminal space is available the axons and axon terminals will not move, at least not over any appreciable distance.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDominance, Cerebral - Physiologyen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshNerve Degenerationen_US
dc.subject.meshOptic Nerve - Anatomy & Histologyen_US
dc.subject.meshRetina - Anatomy & Histologyen_US
dc.subject.meshSensory Deprivationen_US
dc.subject.meshSuperior Colliculi - Anatomy & Histologyen_US
dc.subject.meshThalamic Nuclei - Anatomy & Histologyen_US
dc.subject.meshVisual Pathways - Anatomy & Histologyen_US
dc.titleAbnormal recrossing retinotectal projections after early lesions in Syrian hamsters: age-related effectsen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-8993(78)90840-5en_US
dc.identifier.pmid647401-
dc.identifier.scopuseid_2-s2.0-0017820555en_US
dc.identifier.volume147en_US
dc.identifier.issue2en_US
dc.identifier.spage277en_US
dc.identifier.epage295en_US
dc.identifier.isiWOS:A1978FB73200005-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridSchneider, GE=55057824300en_US

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