File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A study by light and scanning electron microscopy of the lining epithelium of the guinea pig bladder following artificial ulceration

TitleA study by light and scanning electron microscopy of the lining epithelium of the guinea pig bladder following artificial ulceration
Authors
Issue Date1977
Citation
American Journal Of Anatomy, 1977, v. 150 n. 2, p. 219-235 How to Cite?
AbstractFollowing artificial ulceration of the guinea pig bladder epithelium, light microscopic study showed that mitotic activity occurs within 24 hr in the basal layer of the remaining epithelium, which leads to thickening, disorganization and cell shedding. At the ulcer margin, the epithelium forms a rolled edge, from the extremity of which a two-layered sheet of flat cells grows over the edematous ulcer bed, and the ulcer site is protected during dilation of the bladder by localized muscle spasm. Healing is effected within about 1 wk, as the mitotic activity declines. Organization of the new epithelium commences at the periphery and the cells acquire glycogen and alkaline phosphatase. Study by SEM, which included normal bladders, confirmed that new epithelium spreads from a rolled epithelial edge, and also showed that cells undergoing rejection have globular profiles with surface microvilli. The immature epithelial cells are markedly distorted from mutual pressure during migration and their surfaces show only short microvilli. Ulcers heal after 4 to 7 days, depending on size, and the new cells rapidly assume the pentagonal and hexagonal outlines and the reticular pattern of surface ridges, characteristic of mature surface cells. The ridges apparently develop by fusion of rows of microvilli. By the tenth day it is difficult to identify the original ulcer site.
Persistent Identifierhttp://hdl.handle.net/10722/149408
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.contributor.authorMartin, BFen_US
dc.date.accessioned2012-06-26T05:53:20Z-
dc.date.available2012-06-26T05:53:20Z-
dc.date.issued1977en_US
dc.identifier.citationAmerican Journal Of Anatomy, 1977, v. 150 n. 2, p. 219-235en_US
dc.identifier.issn0002-9106en_US
dc.identifier.urihttp://hdl.handle.net/10722/149408-
dc.description.abstractFollowing artificial ulceration of the guinea pig bladder epithelium, light microscopic study showed that mitotic activity occurs within 24 hr in the basal layer of the remaining epithelium, which leads to thickening, disorganization and cell shedding. At the ulcer margin, the epithelium forms a rolled edge, from the extremity of which a two-layered sheet of flat cells grows over the edematous ulcer bed, and the ulcer site is protected during dilation of the bladder by localized muscle spasm. Healing is effected within about 1 wk, as the mitotic activity declines. Organization of the new epithelium commences at the periphery and the cells acquire glycogen and alkaline phosphatase. Study by SEM, which included normal bladders, confirmed that new epithelium spreads from a rolled epithelial edge, and also showed that cells undergoing rejection have globular profiles with surface microvilli. The immature epithelial cells are markedly distorted from mutual pressure during migration and their surfaces show only short microvilli. Ulcers heal after 4 to 7 days, depending on size, and the new cells rapidly assume the pentagonal and hexagonal outlines and the reticular pattern of surface ridges, characteristic of mature surface cells. The ridges apparently develop by fusion of rows of microvilli. By the tenth day it is difficult to identify the original ulcer site.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Anatomyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshEpithelium - Ultrastructureen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMicrovilli - Ultrastructureen_US
dc.subject.meshMitosisen_US
dc.subject.meshUlcer - Pathologyen_US
dc.subject.meshUrinary Bladder - Pathology - Ultrastructureen_US
dc.subject.meshUrinary Bladder Diseases - Pathologyen_US
dc.subject.meshWound Healingen_US
dc.titleA study by light and scanning electron microscopy of the lining epithelium of the guinea pig bladder following artificial ulcerationen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid920629-
dc.identifier.scopuseid_2-s2.0-0017760713en_US
dc.identifier.volume150en_US
dc.identifier.issue2en_US
dc.identifier.spage219en_US
dc.identifier.epage235en_US
dc.identifier.isiWOS:A1977DY87400001-
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridMartin, BF=7402932098en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats