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Article: Mucous metaplasia of the hamster cheek pouch epithelium under hypervitaminosis A

TitleMucous metaplasia of the hamster cheek pouch epithelium under hypervitaminosis A
Authors
Issue Date1975
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmp
Citation
Experimental And Molecular Pathology, 1975, v. 23 n. 1, p. 132-143 How to Cite?
AbstractMucous metaplasia of the hamster cheek pouch epithelium induced by implantation of vitamin A pellet was studied electron microscopically. After 5-10 days of vitamin A treatment, the epithelium was devoid of stratum corneum, and often infiltrated with inflammatory cells. The intercellular spaces were wide, and membrane coating granules underwent modifications believed to be the earliest signs of mucous production. After 15 days of vitamin A treatment the inflammation had largely gone, and the epithelium was made up of several layers of cuboidal cells. The intercellular spaces and keratin fibrils had greatly decreased. Some mucous granules appeared for the first time in the cuboidal superficial cells. Various other changes in the cheek pouch epithelium were observed in animals treated with vitamin A for 20-25 days. In some regions hyperplasia or inflammatory reactions were observed, whereas in other regions complete mucous metaplasia was found. In completely metaplastic regions a surface layer of typical mucous cells was seen lying at the top two or three layers of cuboidal cells.
Persistent Identifierhttp://hdl.handle.net/10722/149399
ISSN
2015 Impact Factor: 2.638
2015 SCImago Journal Rankings: 1.130
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.date.accessioned2012-06-26T05:53:15Z-
dc.date.available2012-06-26T05:53:15Z-
dc.date.issued1975en_US
dc.identifier.citationExperimental And Molecular Pathology, 1975, v. 23 n. 1, p. 132-143en_US
dc.identifier.issn0014-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/149399-
dc.description.abstractMucous metaplasia of the hamster cheek pouch epithelium induced by implantation of vitamin A pellet was studied electron microscopically. After 5-10 days of vitamin A treatment, the epithelium was devoid of stratum corneum, and often infiltrated with inflammatory cells. The intercellular spaces were wide, and membrane coating granules underwent modifications believed to be the earliest signs of mucous production. After 15 days of vitamin A treatment the inflammation had largely gone, and the epithelium was made up of several layers of cuboidal cells. The intercellular spaces and keratin fibrils had greatly decreased. Some mucous granules appeared for the first time in the cuboidal superficial cells. Various other changes in the cheek pouch epithelium were observed in animals treated with vitamin A for 20-25 days. In some regions hyperplasia or inflammatory reactions were observed, whereas in other regions complete mucous metaplasia was found. In completely metaplastic regions a surface layer of typical mucous cells was seen lying at the top two or three layers of cuboidal cells.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmpen_US
dc.relation.ispartofExperimental and Molecular Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCheek - Pathology - Ultrastructureen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshEpithelium - Pathology - Ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMetaplasia - Pathologyen_US
dc.subject.meshMouth Mucosa - Pathology - Ultrastructureen_US
dc.subject.meshMucous Membrane - Pathologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVitamin A - Toxicityen_US
dc.titleMucous metaplasia of the hamster cheek pouch epithelium under hypervitaminosis Aen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1157887-
dc.identifier.scopuseid_2-s2.0-0016691624en_US
dc.identifier.volume23en_US
dc.identifier.issue1en_US
dc.identifier.spage132en_US
dc.identifier.epage143en_US
dc.identifier.isiWOS:A1975AL48100010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US

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