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Article: The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: A systematic review and meta-analysis

TitleThe efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: A systematic review and meta-analysis
Authors
Issue Date2012
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/issn/09652299
Citation
Complementary Therapies In Medicine, 2012, v. 20 n. 4, p. 240-252 How to Cite?
AbstractAlthough Chinese herbal medicine (CHM) has been widely used as an adjunctive therapy for colorectal cancer in Asia, its efficacy is not well defined. The purpose of this systematic review is to assess the efficacy of CHM as an adjunctive therapy to chemotherapy for the patients with colorectal cancer. Randomized controlled trials with CHM to treat colorectal cancer were extensively searched in seven databases. Two researchers independently assessed the quality and validity of included trials and extracted outcome data for synthesis. 20 trials were included for analysis. Compared to using chemotherapy alone, CHM combined with chemotherapy significantly increased 1- and 3-year survival rate [odds ratio (OR) 2.41, 95% confidence interval (CI) 1.32-4.41; OR 2.40, 95% CI 1.49-3.87]. The combined therapy significantly slowed colorectal cancer progression (OR 0.50, 95% CI 0.32-0.77) and improved quality of life (OR 3.43, 95% CI 2.35-5.02). It had positive effects in immunoregulation. CHM as an adjunctive therapy also had significant advantages in reducing the adverse effects of chemotherapy. This systematic review suggests that CHM as an adjunctive therapy with chemotherapy versus chemotherapy alone has significant efficacy in terms of prolonging survival, enhancement of tumor response, improvement of quality of life, immunoregulation, and alleviation of acute adverse effects. However, a firm conclusion could not be reached because of the poor quality of the included trials. Further trials with higher quality are required and the efficacy in other forms of advantages remains to be further determined. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149299
ISSN
2015 Impact Factor: 1.935
2015 SCImago Journal Rankings: 0.649
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhong, LLDen_HK
dc.contributor.authorChen, HYen_HK
dc.contributor.authorCho, WCSen_HK
dc.contributor.authorMeng, XMen_HK
dc.contributor.authorTong, Yen_HK
dc.date.accessioned2012-06-22T06:35:37Z-
dc.date.available2012-06-22T06:35:37Z-
dc.date.issued2012en_HK
dc.identifier.citationComplementary Therapies In Medicine, 2012, v. 20 n. 4, p. 240-252en_HK
dc.identifier.issn0965-2299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149299-
dc.description.abstractAlthough Chinese herbal medicine (CHM) has been widely used as an adjunctive therapy for colorectal cancer in Asia, its efficacy is not well defined. The purpose of this systematic review is to assess the efficacy of CHM as an adjunctive therapy to chemotherapy for the patients with colorectal cancer. Randomized controlled trials with CHM to treat colorectal cancer were extensively searched in seven databases. Two researchers independently assessed the quality and validity of included trials and extracted outcome data for synthesis. 20 trials were included for analysis. Compared to using chemotherapy alone, CHM combined with chemotherapy significantly increased 1- and 3-year survival rate [odds ratio (OR) 2.41, 95% confidence interval (CI) 1.32-4.41; OR 2.40, 95% CI 1.49-3.87]. The combined therapy significantly slowed colorectal cancer progression (OR 0.50, 95% CI 0.32-0.77) and improved quality of life (OR 3.43, 95% CI 2.35-5.02). It had positive effects in immunoregulation. CHM as an adjunctive therapy also had significant advantages in reducing the adverse effects of chemotherapy. This systematic review suggests that CHM as an adjunctive therapy with chemotherapy versus chemotherapy alone has significant efficacy in terms of prolonging survival, enhancement of tumor response, improvement of quality of life, immunoregulation, and alleviation of acute adverse effects. However, a firm conclusion could not be reached because of the poor quality of the included trials. Further trials with higher quality are required and the efficacy in other forms of advantages remains to be further determined. © 2012 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/issn/09652299en_HK
dc.relation.ispartofComplementary Therapies in Medicineen_HK
dc.subject.meshAntineoplastic Agents - adverse effects - therapeutic useen_HK
dc.subject.meshChemotherapy, Adjuvanten_HK
dc.subject.meshColorectal Neoplasms - drug therapy - mortalityen_HK
dc.subject.meshDrugs, Chinese Herbal - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunologic Factors - therapeutic useen_HK
dc.subject.meshOutcome Assessment (Health Care)en_HK
dc.subject.meshPhytotherapyen_HK
dc.subject.meshQuality of Lifeen_HK
dc.titleThe efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: A systematic review and meta-analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ctim.2012.02.004en_HK
dc.identifier.pmid22579437-
dc.identifier.scopuseid_2-s2.0-84862804303en_HK
dc.identifier.hkuros200150en_US
dc.identifier.hkuros223917-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862804303&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue4en_HK
dc.identifier.spage240en_HK
dc.identifier.epage252en_HK
dc.identifier.isiWOS:000304726600011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhong, LLD=55032067800en_HK
dc.identifier.scopusauthoridChen, HY=37051746200en_HK
dc.identifier.scopusauthoridCho, WCS=8615809800en_HK
dc.identifier.scopusauthoridMeng, XM=55043660200en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK

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