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Conference Paper: Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat

TitleEndothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat
Authors
KeywordsBiology
Issue Date2012
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2012 Annual Meeting of Experimental Biology (EB 2012), San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2013, v. 26 meeting abstract, no. 840.1 How to Cite?
AbstractPreliminary experiments showed that in the aorta of male spontaneously hypertensive (SHR), but not in that of normotensive Wistar-Kyoto (WKY) rats, contractions to phenylephrine (PE) are inhibited in preparations with endothelium despite the presence of indomethacin and L-NAME. The present study aimed to identify the mechanism underlying this endothelium-dependent inhibition in the SHR aorta. Aortic rings, with and without endothelium, of male SHR and WKY were suspended in organ chambers for the measurement of isometric tension. Contractions to PE were smaller in SHR aorta with than in those without endothelium. The inhibitory effect of the endothelium was larger in preparations from adult than in those from young SHR. The endothelium-dependent difference in contraction to PE was abolished by the NO scavengers oxyhemoglobin and carboxy-PTIO, by the inhibitor of soluble guanylyl cyclase ODQ, and the by inhibitor of cytochrome P450 reductase (CPR) diphenyleneiodonium. PE-induced contractions in adult WKY aortic rings with endothelium were not affected by carboxy-PTIO. Thus, in the SHR, there is an endothelium-dependent release of NO which is not produced by NOS but by CPR. Nitrate is the likely source of this NOS-independent endothelial NO. The NOS-independent NO release is observed only in preparations from hypertensive animals and increases with age.
DescriptionSession - 840. Endothelium Dysfunction - Poster: no. 840.1
Persistent Identifierhttp://hdl.handle.net/10722/149248
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorZhao, Yen_US
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-06-22T06:32:06Z-
dc.date.available2012-06-22T06:32:06Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Annual Meeting of Experimental Biology (EB 2012), San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2013, v. 26 meeting abstract, no. 840.1en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/149248-
dc.descriptionSession - 840. Endothelium Dysfunction - Poster: no. 840.1-
dc.description.abstractPreliminary experiments showed that in the aorta of male spontaneously hypertensive (SHR), but not in that of normotensive Wistar-Kyoto (WKY) rats, contractions to phenylephrine (PE) are inhibited in preparations with endothelium despite the presence of indomethacin and L-NAME. The present study aimed to identify the mechanism underlying this endothelium-dependent inhibition in the SHR aorta. Aortic rings, with and without endothelium, of male SHR and WKY were suspended in organ chambers for the measurement of isometric tension. Contractions to PE were smaller in SHR aorta with than in those without endothelium. The inhibitory effect of the endothelium was larger in preparations from adult than in those from young SHR. The endothelium-dependent difference in contraction to PE was abolished by the NO scavengers oxyhemoglobin and carboxy-PTIO, by the inhibitor of soluble guanylyl cyclase ODQ, and the by inhibitor of cytochrome P450 reductase (CPR) diphenyleneiodonium. PE-induced contractions in adult WKY aortic rings with endothelium were not affected by carboxy-PTIO. Thus, in the SHR, there is an endothelium-dependent release of NO which is not produced by NOS but by CPR. Nitrate is the likely source of this NOS-independent endothelial NO. The NOS-independent NO release is observed only in preparations from hypertensive animals and increases with age.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titleEndothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive raten_US
dc.typeConference_Paperen_US
dc.identifier.emailLeung, SWS: swsleung@hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros200069en_US
dc.identifier.volume26-
dc.identifier.issuemeeting abstract-
dc.publisher.placeUnited States-

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