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Conference Paper: Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts

TitleLipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts
Authors
KeywordsBiology
Issue Date2012
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2012 Annual Meeting of Experimental Biology (EB 2012), San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2012, v. 26 meeting abstract, no. 1114.4 How to Cite?
Abstract
Lipocalin-2, a 25-kDa glycoprotein secreted by adipocytes, belongs to the diversified lipocalin family. Although its physiological functions remain elusive, the expression of this protein is up-regulated or rapidly induced under various pathological conditions. The impact of lipocalin-2 on extracellular matrix (ECM) remodeling was determined in cardiac cells of wild type rats. Incubation of primary cultured fibroblasts with recombinant lipocalin-2 promoted both intracellular collagen expression and extracellular collagen secretion. Up-regulation of collagen production was also shown in infarcted cardiac tissues after permanent coronary artery ligation in wild type mice, which was positively correlated with enhanced levels of lipocalin-2 in serum or the infracted heart tissues. The phosphorylation levels of Akt and/or P-38 were significantly decreased by lipocalin-2 treatment in primary cultured cardiomyocytes, fibroblasts or infarcted heart tissues. Gelatin zymography analysis of matrix metalloproteinase-2 (MMP-2) activity in conditioned medium collected from fibroblasts demonstrated that lipocalin-2 treatment significantly induced MMP-2 activity. These results demonstrate that lipocalin-2 plays a role in mediating myocardial ECM remodeling and that the Akt/P-38 pathways mediate these effects of the adipokine.
DescriptionSession - 1114. Cardioprotection - Poster: no. 1114.4
Persistent Identifierhttp://hdl.handle.net/10722/149247
ISSN
2013 Impact Factor: 5.480

 

DC FieldValueLanguage
dc.contributor.authorYang, Ben_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorWang, Yen_US
dc.date.accessioned2012-06-22T06:32:06Z-
dc.date.available2012-06-22T06:32:06Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Annual Meeting of Experimental Biology (EB 2012), San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2012, v. 26 meeting abstract, no. 1114.4en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/149247-
dc.descriptionSession - 1114. Cardioprotection - Poster: no. 1114.4-
dc.description.abstractLipocalin-2, a 25-kDa glycoprotein secreted by adipocytes, belongs to the diversified lipocalin family. Although its physiological functions remain elusive, the expression of this protein is up-regulated or rapidly induced under various pathological conditions. The impact of lipocalin-2 on extracellular matrix (ECM) remodeling was determined in cardiac cells of wild type rats. Incubation of primary cultured fibroblasts with recombinant lipocalin-2 promoted both intracellular collagen expression and extracellular collagen secretion. Up-regulation of collagen production was also shown in infarcted cardiac tissues after permanent coronary artery ligation in wild type mice, which was positively correlated with enhanced levels of lipocalin-2 in serum or the infracted heart tissues. The phosphorylation levels of Akt and/or P-38 were significantly decreased by lipocalin-2 treatment in primary cultured cardiomyocytes, fibroblasts or infarcted heart tissues. Gelatin zymography analysis of matrix metalloproteinase-2 (MMP-2) activity in conditioned medium collected from fibroblasts demonstrated that lipocalin-2 treatment significantly induced MMP-2 activity. These results demonstrate that lipocalin-2 plays a role in mediating myocardial ECM remodeling and that the Akt/P-38 pathways mediate these effects of the adipokine.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titleLipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in heartsen_US
dc.typeConference_Paperen_US
dc.identifier.emailYang, B: boyang@hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.emailWang, Y: yuwanghk@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.identifier.authorityWang, Y=rp00239en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros200068en_US
dc.identifier.volume26-
dc.identifier.issuemeeting abstract-
dc.publisher.placeUnited States-

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