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Conference Paper: Epac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathway

TitleEpac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathway
Authors
Kwan, SYWLeung, SWSMan, RYK
Issue Date2011
PublisherBritish Pharmacological Society.
Citation
The 2011 Winter Meeting of the British Pharmacological Society (BPS), London, UK., 13-15 December 2011, abstract no. P041 How to Cite?
AbstractBACKGROUND: Exchange protein directly activated by cyclic AMP (cAMP) 1, Epac1, is a newly discovered cAMP target which acts beyond the classical cAMP effector protein kinase A (PKA). The identification of Epac1 overthrows the concept that cAMP activatez single effector. Epac1 is a guanine nucleotide exchange factor (GEF) probably activates small G-protein Rap1. Epac1 ubiquitously expresses in all tissues and therefore should play important roles in cellular signaling. Appreciation of the potential importance of Epac1 has come with the current development of Epac1-selective-cAMP analogs for discriminating the activation from PKA to Epac1. Among those analogs …
Persistent Identifierhttp://hdl.handle.net/10722/149244

 

DC FieldValueLanguage
dc.contributor.authorKwan, SYWen_US
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-06-22T06:32:05Z-
dc.date.available2012-06-22T06:32:05Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Winter Meeting of the British Pharmacological Society (BPS), London, UK., 13-15 December 2011, abstract no. P041en_US
dc.identifier.urihttp://hdl.handle.net/10722/149244-
dc.description.abstractBACKGROUND: Exchange protein directly activated by cyclic AMP (cAMP) 1, Epac1, is a newly discovered cAMP target which acts beyond the classical cAMP effector protein kinase A (PKA). The identification of Epac1 overthrows the concept that cAMP activatez single effector. Epac1 is a guanine nucleotide exchange factor (GEF) probably activates small G-protein Rap1. Epac1 ubiquitously expresses in all tissues and therefore should play important roles in cellular signaling. Appreciation of the potential importance of Epac1 has come with the current development of Epac1-selective-cAMP analogs for discriminating the activation from PKA to Epac1. Among those analogs …-
dc.languageengen_US
dc.publisherBritish Pharmacological Society.-
dc.relation.ispartofBPS 2011 Winter Meetingen_US
dc.titleEpac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathwayen_US
dc.typeConference_Paperen_US
dc.identifier.emailKwan, SYW: h1094107@hku.hken_US
dc.identifier.emailLeung, SWS: swsleung@hku.hken_US
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hk-
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturepostprint-
dc.identifier.hkuros200052en_US
dc.publisher.placeUnited Kingdom-
dc.description.otherThe 2011 Winter Meeting of the British Pharmacological Society (BPS), London, U.K., 13-15 December 2011, abstract no. P041-

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