File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

TitleAdiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease
Authors
KeywordsAdipose tissue
Endothelial dysfunction
Inflammation
Issue Date2012
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 2012, v. 302 n. 6, p. H1231-H1240 How to Cite?
AbstractThe heart and blood vessels are surrounded by epicardial and perivascular adipose tissues, respectively, which play important roles in maintaining cardiovascular homeostasis by secreting a number of biologically active molecules, termed "adipokines." Many of these adipokines function as an important component of the 'adipo-cardiovascular axis' mediating the cross talk between adipose tissues, the heart, and the vasculature. On the one hand, most adipokines [including tumor necrosis factor-α, resistin, adipocyte fatty acid binding protein (A-FABP), and lipocalin-2] are proinflammatory and causally associated with endothelial and cardiac dysfunction by their endocrine/paracrine actions. On the other hand, adiponectin is one of the few adipokines that possesses multiple salutary effects on the prevention of cardiovascular disease, because of its pleiotropic actions on the heart and the blood vessels. The discordant production of adipokines in dysfunctional adipose tissue is a key contributor to obesity-related cardiovascular disease. This review provides an update in understanding the roles of adipokines in the pathogenesis of cardiovascular disorders associated with obesity and diabetes and focuses on the two most abundant adipokines, adiponectin and A-FABP. Indeed, data from both animal studies and clinical investigations imply that these two adipokines are prognostic biomarkers for cardiovascular disease and even promising therapeutic targets for its treatment. © 2012 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/149119
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823
ISI Accession Number ID
Funding AgencyGrant Number
NSFC/RGC Joint Research SchemeN_HKU 735/08
Research Grants Council of Hong Kong
University of Hong Kong
HKU2/07C
HKU4/10/CRF
Funding Information:

We were supported by a collaborative research fund (HKU2/07C and HKU4/10/CRF) and the NSFC/RGC Joint Research Scheme (N_HKU 735/08), from the Research Grants Council of Hong Kong, and the matching funding for National 973 basic research project from the University of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorXu, Aen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.date.accessioned2012-06-22T06:24:15Z-
dc.date.available2012-06-22T06:24:15Z-
dc.date.issued2012en_HK
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 2012, v. 302 n. 6, p. H1231-H1240en_HK
dc.identifier.issn0363-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149119-
dc.description.abstractThe heart and blood vessels are surrounded by epicardial and perivascular adipose tissues, respectively, which play important roles in maintaining cardiovascular homeostasis by secreting a number of biologically active molecules, termed "adipokines." Many of these adipokines function as an important component of the 'adipo-cardiovascular axis' mediating the cross talk between adipose tissues, the heart, and the vasculature. On the one hand, most adipokines [including tumor necrosis factor-α, resistin, adipocyte fatty acid binding protein (A-FABP), and lipocalin-2] are proinflammatory and causally associated with endothelial and cardiac dysfunction by their endocrine/paracrine actions. On the other hand, adiponectin is one of the few adipokines that possesses multiple salutary effects on the prevention of cardiovascular disease, because of its pleiotropic actions on the heart and the blood vessels. The discordant production of adipokines in dysfunctional adipose tissue is a key contributor to obesity-related cardiovascular disease. This review provides an update in understanding the roles of adipokines in the pathogenesis of cardiovascular disorders associated with obesity and diabetes and focuses on the two most abundant adipokines, adiponectin and A-FABP. Indeed, data from both animal studies and clinical investigations imply that these two adipokines are prognostic biomarkers for cardiovascular disease and even promising therapeutic targets for its treatment. © 2012 the American Physiological Society.en_HK
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_HK
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_HK
dc.rightsAmerican Journal of Physiology: Heart and Circulatory Physiology. Copyright © American Physiological Society.-
dc.rightsThis is an unofficial adaptation or translation of an article that appeared in a publication of the American Physiological Society. The American Physiological Society has not endorsed the content of this adaptation or translation, or the context of its use.-
dc.subjectAdipose tissueen_HK
dc.subjectEndothelial dysfunctionen_HK
dc.subjectInflammationen_HK
dc.subject.meshAdiponectin - metabolism-
dc.subject.meshAdipose Tissue - metabolism-
dc.subject.meshBlood Vessels - metabolism-
dc.subject.meshCardiovascular Diseases - etiology - metabolism - prevention and control-
dc.subject.meshFatty Acid-Binding Proteins - metabolism-
dc.titleAdiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/ajpheart.00765.2011en_HK
dc.identifier.pmid22210749-
dc.identifier.scopuseid_2-s2.0-84858268902en_HK
dc.identifier.hkuros200000en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858268902&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume302en_HK
dc.identifier.issue6en_HK
dc.identifier.spageH1231en_HK
dc.identifier.epageH1240en_HK
dc.identifier.isiWOS:000301792800002-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectAdipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications-
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats