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Article: Genetic polymorphism studies in periodontitis and Fcγ receptors
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TitleGenetic polymorphism studies in periodontitis and Fcγ receptors
 
AuthorsChai, L2
Song, YQ1
Leung, WK3
 
KeywordsFcγ receptor
Genetics
Periodontitis
Polymorphism
Receptor
 
Issue Date2012
 
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
 
CitationJournal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x
 
AbstractPeriodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.
 
ISSN0022-3484
2013 Impact Factor: 2.215
 
DOIhttp://dx.doi.org/10.1111/j.1600-0765.2011.01437.x
 
ISI Accession Number IDWOS:000302999400001
Funding AgencyGrant Number
University Research Committee10206094
10207348
Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU772110M
Funding Information:

The work described in this paper was fully supported by University Research Committee Grants 10206094 and 10207348, as well as partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU772110M). A draft of the manuscript was edited by Trevor Lane, Faculty of Dentistry, The University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChai, L
 
dc.contributor.authorSong, YQ
 
dc.contributor.authorLeung, WK
 
dc.date.accessioned2012-06-22T06:18:54Z
 
dc.date.available2012-06-22T06:18:54Z
 
dc.date.issued2012
 
dc.description.abstractPeriodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.
 
dc.description.naturepostprint
 
dc.identifier.citationJournal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0765.2011.01437.x
 
dc.identifier.epage285
 
dc.identifier.hkuros199917
 
dc.identifier.hkuros204010
 
dc.identifier.isiWOS:000302999400001
Funding AgencyGrant Number
University Research Committee10206094
10207348
Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU772110M
Funding Information:

The work described in this paper was fully supported by University Research Committee Grants 10206094 and 10207348, as well as partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU772110M). A draft of the manuscript was edited by Trevor Lane, Faculty of Dentistry, The University of Hong Kong.

 
dc.identifier.issn0022-3484
2013 Impact Factor: 2.215
 
dc.identifier.issue3
 
dc.identifier.pmid22117888
 
dc.identifier.scopuseid_2-s2.0-84859954530
 
dc.identifier.spage273
 
dc.identifier.urihttp://hdl.handle.net/10722/149047
 
dc.identifier.volume47
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Periodontal Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectFcγ receptor
 
dc.subjectGenetics
 
dc.subjectPeriodontitis
 
dc.subjectPolymorphism
 
dc.subjectReceptor
 
dc.titleGenetic polymorphism studies in periodontitis and Fcγ receptors
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. University of Queensland
  3. The University of Hong Kong