File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Genetic polymorphism studies in periodontitis and Fcγ receptors

TitleGenetic polymorphism studies in periodontitis and Fcγ receptors
Authors
KeywordsFcγ receptor
Genetics
Periodontitis
Polymorphism
Receptor
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285 How to Cite?
Abstract
Periodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/149047
ISSN
2013 Impact Factor: 2.215
ISI Accession Number ID
Funding AgencyGrant Number
University Research Committee10206094
10207348
Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU772110M
Funding Information:

The work described in this paper was fully supported by University Research Committee Grants 10206094 and 10207348, as well as partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU772110M). A draft of the manuscript was edited by Trevor Lane, Faculty of Dentistry, The University of Hong Kong.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. University of Queensland
  3. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChai, Len_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2012-06-22T06:18:54Z-
dc.date.available2012-06-22T06:18:54Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285en_HK
dc.identifier.issn0022-3484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149047-
dc.description.abstractPeriodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_HK
dc.relation.ispartofJournal of Periodontal Researchen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFcγ receptoren_HK
dc.subjectGeneticsen_HK
dc.subjectPeriodontitisen_HK
dc.subjectPolymorphismen_HK
dc.subjectReceptoren_HK
dc.titleGenetic polymorphism studies in periodontitis and Fcγ receptorsen_HK
dc.typeArticleen_HK
dc.identifier.emailChai, L: l.chai@uq.edu.auen_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1111/j.1600-0765.2011.01437.xen_HK
dc.identifier.pmid22117888-
dc.identifier.scopuseid_2-s2.0-84859954530en_HK
dc.identifier.hkuros199917en_US
dc.identifier.hkuros204010-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859954530&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue3en_HK
dc.identifier.spage273en_HK
dc.identifier.epage285en_HK
dc.identifier.isiWOS:000302999400001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK
dc.identifier.scopusauthoridSong, YQ=54407744600en_HK
dc.identifier.scopusauthoridChai, L=36196100600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats