Article: Genetic polymorphism studies in periodontitis and Fcγ receptors
| Title | Genetic polymorphism studies in periodontitis and Fcγ receptors | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Chai, L2 Song, YQ1 Leung, WK3 | ||||||
| Keywords | Fcγ receptor Genetics Periodontitis Polymorphism Receptor | ||||||
| Issue Date | 2012 | ||||||
| Publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1 | ||||||
| Citation | Journal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x | ||||||
| Abstract | Periodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed. | ||||||
| ISSN | 0022-3484 2011 Impact Factor: 1.686 2011 SCImago Journal Rankings: 0.120 | ||||||
| DOI | http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x | ||||||
| ISI Accession Number ID | WOS:000302999400001
Funding Information: The work described in this paper was fully supported by University Research Committee Grants 10206094 and 10207348, as well as partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU772110M). A draft of the manuscript was edited by Trevor Lane, Faculty of Dentistry, The University of Hong Kong. | ||||||
| References | References in Scopus |
| dc.contributor.author | Chai, L | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Song, YQ | ||||||
| dc.contributor.author | Leung, WK | ||||||
| dc.date.accessioned | 2012-06-22T06:18:54Z | ||||||
| dc.date.available | 2012-06-22T06:18:54Z | ||||||
| dc.date.issued | 2012 | ||||||
| dc.description.abstract | Periodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcgamma receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcgamma receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcgamma receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcgamma receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Journal of Periodontal Research, 2012, v. 47 n. 3, p. 273-285 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1600-0765.2011.01437.x | ||||||
| dc.identifier.epage | 285 | ||||||
| dc.identifier.hkuros | 199917 | ||||||
| dc.identifier.hkuros | 204010 | ||||||
| dc.identifier.isi | WOS:000302999400001
Funding Information: The work described in this paper was fully supported by University Research Committee Grants 10206094 and 10207348, as well as partially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU772110M). A draft of the manuscript was edited by Trevor Lane, Faculty of Dentistry, The University of Hong Kong. | ||||||
| dc.identifier.issn | 0022-3484 2011 Impact Factor: 1.686 2011 SCImago Journal Rankings: 0.120 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.pmid | 22117888 | ||||||
| dc.identifier.scopus | eid_2-s2.0-84859954530 | ||||||
| dc.identifier.spage | 273 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/149047 | ||||||
| dc.identifier.volume | 47 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1 | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Journal of Periodontal Research | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | The definitive version is available at www3.interscience.wiley.com | ||||||
| dc.subject | Fcγ receptor | ||||||
| dc.subject | Genetics | ||||||
| dc.subject | Periodontitis | ||||||
| dc.subject | Polymorphism | ||||||
| dc.subject | Receptor | ||||||
| dc.title | Genetic polymorphism studies in periodontitis and Fcγ receptors | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- University of Queensland
- The University of Hong Kong