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Article: Altered serum levels of the osteoclast-specific TRACP 5b isoform in Chinese children undergoing orthodontic treatment

TitleAltered serum levels of the osteoclast-specific TRACP 5b isoform in Chinese children undergoing orthodontic treatment
Authors
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
Citation
European Journal of Orthodontics, 2013, v. 35 n. 2, p. 169-174 How to Cite?
AbstractOrthodontic tooth movement is dependent upon the ability of mechanical forces to induce remodelling activity within the tooth-supporting alveolar bone. In view of the importance of bone resorption in mediating tooth movement, the aim of this study was to establish if alterations in the osteoclast-specific bone marker tartrate-resistant acid phosphatase (TRACP) 5b could be detected in the sera of patients undergoing orthodontic treatment. The sample consisted of 14 subjects (10 girls and 4 boys) aged 10.5-16.5 years (mean 12.6 years) being treated with fixed appliances and a distalizing headgear. Venous blood samples (3 ml) were collected from the cubital vein pre-treatment (T0) and 2, 4, and 6 months into treatment (T1-T3); serum TRACP 5b levels were quantified using a solid-phase immunofixed enzyme activity assay. When the data were pooled and treated cross-sectionally, a significant increase in immunoreactive TRACP 5b was detected at 2 months (T1) indicating increased bone resorptive activity. However, when the serum profiles of individual patients were recorded longitudinally, a very different pattern emerged, not all patients following the same trend. This is not surprising given normal anatomical variation and differences between the patients in age, gender, and mechanotherapy. Designed as a pilot to demonstrate 'proof of principle', this study is the first to show that the TRACP 5b isoform can be detected in the sera of patients undergoing orthodontic treatment. It further suggests that serum bone marker measurements offer a simple and minimally invasive method for correlating the findings of laboratory and animal experimentation with clinical data.
Persistent Identifierhttp://hdl.handle.net/10722/149046
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, SJen_US
dc.contributor.authorMeikle, MCen_US
dc.contributor.authorMacLaine, JKen_US
dc.contributor.authorWong, RWKen_US
dc.contributor.authorRabie, BMen_US
dc.date.accessioned2012-06-22T06:18:53Z-
dc.date.available2012-06-22T06:18:53Z-
dc.date.issued2013en_US
dc.identifier.citationEuropean Journal of Orthodontics, 2013, v. 35 n. 2, p. 169-174en_US
dc.identifier.issn0141-5387-
dc.identifier.urihttp://hdl.handle.net/10722/149046-
dc.description.abstractOrthodontic tooth movement is dependent upon the ability of mechanical forces to induce remodelling activity within the tooth-supporting alveolar bone. In view of the importance of bone resorption in mediating tooth movement, the aim of this study was to establish if alterations in the osteoclast-specific bone marker tartrate-resistant acid phosphatase (TRACP) 5b could be detected in the sera of patients undergoing orthodontic treatment. The sample consisted of 14 subjects (10 girls and 4 boys) aged 10.5-16.5 years (mean 12.6 years) being treated with fixed appliances and a distalizing headgear. Venous blood samples (3 ml) were collected from the cubital vein pre-treatment (T0) and 2, 4, and 6 months into treatment (T1-T3); serum TRACP 5b levels were quantified using a solid-phase immunofixed enzyme activity assay. When the data were pooled and treated cross-sectionally, a significant increase in immunoreactive TRACP 5b was detected at 2 months (T1) indicating increased bone resorptive activity. However, when the serum profiles of individual patients were recorded longitudinally, a very different pattern emerged, not all patients following the same trend. This is not surprising given normal anatomical variation and differences between the patients in age, gender, and mechanotherapy. Designed as a pilot to demonstrate 'proof of principle', this study is the first to show that the TRACP 5b isoform can be detected in the sera of patients undergoing orthodontic treatment. It further suggests that serum bone marker measurements offer a simple and minimally invasive method for correlating the findings of laboratory and animal experimentation with clinical data.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/-
dc.relation.ispartofEuropean Journal of Orthodonticsen_US
dc.titleAltered serum levels of the osteoclast-specific TRACP 5b isoform in Chinese children undergoing orthodontic treatmenten_US
dc.typeArticleen_US
dc.identifier.emailMeikle, MC: denmcm@nus.edu.sgen_US
dc.identifier.emailWong, RWK: fyoung@hku.hk-
dc.identifier.authorityWong, RWK=rp00038en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/cjs013-
dc.identifier.pmid22467569-
dc.identifier.hkuros199865en_US
dc.identifier.isiWOS:000316956000004-
dc.publisher.placeUnited Kingdom-

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