Conference Paper: An interstitial fluid transdermal extraction, collection and measurement system

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TitleAn interstitial fluid transdermal extraction, collection and measurement system
AuthorsYu, H
Li, D
Xu, K
Roberts, RC
Tien, NC
KeywordsContinuous Glucose Monitoring
Flow Sensor
Interstitial Fluid
PDMS
Venturi Tube
Issue Date2011
CitationNems 2011 - 6Th Ieee International Conference On Nano/Micro Engineered And Molecular Systems, 2011, p. 1237-1240 [How to Cite?]
DOI: http://dx.doi.org/10.1109/NEMS.2011.6017581
AbstractWe present a new microfluidic system for transdermal interstitial fluid (ISF) extraction, collection, and volumetric measurement towards the application of noninvasive, continuous, and real-time glucose monitoring. This device consists of a Venturi Tube for vacuum generation, chambers for the introduction of ISF and normal saline solution, pneumatic valves for fluid control, and flow sensors for ISF and normal saline solution volumetric measurement. Under the control of pneumatic valves, demonstration of the normal saline injection, ISF extraction and collection functions of the system is presented using the stable vacuum generated by the integrated Venturi structure. A test volume of deionized water is measured using the flow sensor, and the measurement results are compared with the values measured by micro syringe. The data correlates well with each other (R 2=0.9952). © 2011 IEEE.
DOIhttp://dx.doi.org/10.1109/NEMS.2011.6017581
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYu, H
dc.contributor.authorLi, D
dc.contributor.authorXu, K
dc.contributor.authorRoberts, RC
dc.contributor.authorTien, NC
dc.date.accessioned2012-06-20T06:18:01Z
dc.date.available2012-06-20T06:18:01Z
dc.date.issued2011
dc.description.abstractWe present a new microfluidic system for transdermal interstitial fluid (ISF) extraction, collection, and volumetric measurement towards the application of noninvasive, continuous, and real-time glucose monitoring. This device consists of a Venturi Tube for vacuum generation, chambers for the introduction of ISF and normal saline solution, pneumatic valves for fluid control, and flow sensors for ISF and normal saline solution volumetric measurement. Under the control of pneumatic valves, demonstration of the normal saline injection, ISF extraction and collection functions of the system is presented using the stable vacuum generated by the integrated Venturi structure. A test volume of deionized water is measured using the flow sensor, and the measurement results are compared with the values measured by micro syringe. The data correlates well with each other (R 2=0.9952). © 2011 IEEE.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNems 2011 - 6Th Ieee International Conference On Nano/Micro Engineered And Molecular Systems, 2011, p. 1237-1240 [How to Cite?]
DOI: http://dx.doi.org/10.1109/NEMS.2011.6017581
dc.identifier.doihttp://dx.doi.org/10.1109/NEMS.2011.6017581
dc.identifier.epage1240
dc.identifier.scopuseid_2-s2.0-80053295704
dc.identifier.spage1237
dc.identifier.urihttp://hdl.handle.net/10722/149036
dc.languageeng
dc.relation.ispartofNEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
dc.relation.referencesReferences in Scopus
dc.subjectContinuous Glucose Monitoring
dc.subjectFlow Sensor
dc.subjectInterstitial Fluid
dc.subjectPDMS
dc.subjectVenturi Tube
dc.titleAn interstitial fluid transdermal extraction, collection and measurement system
dc.typeConference_Paper
Author Affiliations
  1. Case Western Reserve University
  2. Tianjin University