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Article: Stimulation of corticosterone release in the fowl by recombinant DNA-derived chicken growth hormone

TitleStimulation of corticosterone release in the fowl by recombinant DNA-derived chicken growth hormone
Authors
Issue Date1988
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 1988, v. 69 n. 1, p. 128-132 How to Cite?
AbstractThe effects of recombinant DNA-derived chicken growth hormone (rcGH) on plasma corticosterone in young broiler cockerels were investigated. A single injection of 200 μg/kg rcGH significantly increased plasma corticosterone concentrations 2 hr (but not 20 or 40 min) after treatment. Administration of 10 or 100 μg/kg rcGH also significantly increased plasma corticosterone levels after 2 hr, with the higher dose eliciting greater responses. Chronic treatment with seven daily injections of the same doses of rcGH gave similar increases in plasma concentrations of corticosterone. No obvious difference in magnitude of plasma corticosterone was observed between acute and chronic exposure to rcGH. In a further experiment in which serial blood sampling was performed after a single injection or five daily injections of vehicle or 200 μg/kg rcGH, there were significant increases in plasma corticosterone concentrations 40 min after acute rcGH treatment and 40 and 80 min after chronic treatment when compared with plasma corticosterone concentrations of vehicle-injected controls. However, the increases could have incorporated a stress response due to repeated sampling because the control birds also showed elevated plasma corticosterone concentrations. The corticosterone response did not diminish with repeated GH challenge. These results suggest that GH may play a role in the acute regulation of corticosterone secretion in intact chickens.
Persistent Identifierhttp://hdl.handle.net/10722/148869
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, Aen_US
dc.contributor.authorHall, TRen_US
dc.contributor.authorHarvey, Sen_US
dc.date.accessioned2012-06-20T06:15:49Z-
dc.date.available2012-06-20T06:15:49Z-
dc.date.issued1988en_US
dc.identifier.citationGeneral And Comparative Endocrinology, 1988, v. 69 n. 1, p. 128-132en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://hdl.handle.net/10722/148869-
dc.description.abstractThe effects of recombinant DNA-derived chicken growth hormone (rcGH) on plasma corticosterone in young broiler cockerels were investigated. A single injection of 200 μg/kg rcGH significantly increased plasma corticosterone concentrations 2 hr (but not 20 or 40 min) after treatment. Administration of 10 or 100 μg/kg rcGH also significantly increased plasma corticosterone levels after 2 hr, with the higher dose eliciting greater responses. Chronic treatment with seven daily injections of the same doses of rcGH gave similar increases in plasma concentrations of corticosterone. No obvious difference in magnitude of plasma corticosterone was observed between acute and chronic exposure to rcGH. In a further experiment in which serial blood sampling was performed after a single injection or five daily injections of vehicle or 200 μg/kg rcGH, there were significant increases in plasma corticosterone concentrations 40 min after acute rcGH treatment and 40 and 80 min after chronic treatment when compared with plasma corticosterone concentrations of vehicle-injected controls. However, the increases could have incorporated a stress response due to repeated sampling because the control birds also showed elevated plasma corticosterone concentrations. The corticosterone response did not diminish with repeated GH challenge. These results suggest that GH may play a role in the acute regulation of corticosterone secretion in intact chickens.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickens - Blooden_US
dc.subject.meshCorticosterone - Blooden_US
dc.subject.meshGrowth Hormone - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRecombinant Proteins - Pharmacologyen_US
dc.subject.meshTime Factorsen_US
dc.titleStimulation of corticosterone release in the fowl by recombinant DNA-derived chicken growth hormoneen_US
dc.typeArticleen_US
dc.identifier.emailCheung, A:lmcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, A=rp00332en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3360286-
dc.identifier.scopuseid_2-s2.0-0023860913en_US
dc.identifier.volume69en_US
dc.identifier.issue1en_US
dc.identifier.spage128en_US
dc.identifier.epage132en_US
dc.identifier.isiWOS:A1988L875300016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, A=8323783300en_US
dc.identifier.scopusauthoridHall, TR=7402483718en_US
dc.identifier.scopusauthoridHarvey, S=7202020846en_US

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