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Article: Some biological activities of recombinant DNA-derived growth hormone on plasma metabolite concentrations in domestic fowl

TitleSome biological activities of recombinant DNA-derived growth hormone on plasma metabolite concentrations in domestic fowl
Authors
Issue Date1987
PublisherElsevier Inc.
Citation
Comparative Biochemistry and Physiology. A, Comparative Physiology, 1987, v. 86 n. 1, p. 29-34 How to Cite?
AbstractThe biological activity of recombinant-DNA-derived chicken growth hormone (rcGH) has been examined in young broiler cockerels, by determining its effects on plasma concentrations of glucose, free fatty acids and alpha-amino nitrogen. A single injection of rcGH increased plasma glucose, which remained high for several hours, whereas daily treatment with rcGH for 1 week had no effect on basal plasma glucose concentrations but blunted the glucose response to a further rcGH challenge. Plasma free fatty acids were also promptly increased following acute rcGH treatment, and chronic exposure to rcGH again attenuated this response. The effects of rcGH on plasma alpha-amino nitrogen were more variable. The stress of repeated blood sampling tended to reduce alpha-amino nitrogen, and after rcGH, an increase relative to vehicle-injected controls was seen in both acute and chronically-treated birds. These data suggest that rcGH has both hyperglycaemic and lipolytic activity in chickens, and may also increase amino acid availability.
Persistent Identifierhttp://hdl.handle.net/10722/148867
ISSN
2000 SCImago Journal Rankings: 0.403
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHall, TRen_US
dc.contributor.authorCheung, Aen_US
dc.contributor.authorHarvey, Sen_US
dc.date.accessioned2012-06-20T06:15:48Z-
dc.date.available2012-06-20T06:15:48Z-
dc.date.issued1987en_US
dc.identifier.citationComparative Biochemistry and Physiology. A, Comparative Physiology, 1987, v. 86 n. 1, p. 29-34en_US
dc.identifier.issn0300-9629en_US
dc.identifier.urihttp://hdl.handle.net/10722/148867-
dc.description.abstractThe biological activity of recombinant-DNA-derived chicken growth hormone (rcGH) has been examined in young broiler cockerels, by determining its effects on plasma concentrations of glucose, free fatty acids and alpha-amino nitrogen. A single injection of rcGH increased plasma glucose, which remained high for several hours, whereas daily treatment with rcGH for 1 week had no effect on basal plasma glucose concentrations but blunted the glucose response to a further rcGH challenge. Plasma free fatty acids were also promptly increased following acute rcGH treatment, and chronic exposure to rcGH again attenuated this response. The effects of rcGH on plasma alpha-amino nitrogen were more variable. The stress of repeated blood sampling tended to reduce alpha-amino nitrogen, and after rcGH, an increase relative to vehicle-injected controls was seen in both acute and chronically-treated birds. These data suggest that rcGH has both hyperglycaemic and lipolytic activity in chickens, and may also increase amino acid availability.-
dc.languageengen_US
dc.publisherElsevier Inc.-
dc.relation.ispartofComparative Biochemistry and Physiology. A, Comparative Physiologyen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Comparative Biochemistry and Physiology. A, Comparative Physiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Comparative Biochemistry and Physiology. A, Comparative Physiology, [VOL 86, ISSUE 1, 1987]-
dc.subject.meshAmines - blood-
dc.subject.meshBlood Glucose - metabolism-
dc.subject.meshFatty Acids, Nonesterified - blood-
dc.subject.meshGrowth Hormone - pharmacology-
dc.subject.meshRecombinant Proteins - pharmacology-
dc.titleSome biological activities of recombinant DNA-derived growth hormone on plasma metabolite concentrations in domestic fowlen_US
dc.typeArticleen_US
dc.identifier.emailCheung, A: lmcheung@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid2881653-
dc.identifier.scopuseid_2-s2.0-0023253011-
dc.identifier.volume86en_US
dc.identifier.issue1en_US
dc.identifier.spage29en_US
dc.identifier.epage34en_US
dc.identifier.isiWOS:A1987F683700005-
dc.publisher.placeEngland-

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