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Article: Serotoninergic regulation of corticosterone secretion in domestic fowl

TitleSerotoninergic regulation of corticosterone secretion in domestic fowl
Authors
Issue Date1987
PublisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.org
Citation
Journal Of Endocrinology, 1987, v. 113 n. 2, p. 159-165 How to Cite?
AbstractThe effects of serotoninergic drugs on adrenocortical function in domestic fowl were examined. Administration of the serotonin receptor agonist 2-(1-piperazinyl)quinoline maleate (quipazine), an inhibitor of serotonin metabolism, N-methyl-N-2-propynylbenzylamine HCl (pargyline), as well as serotonin itself, all increased plasma concentrations of corticosterone. The maximum responses to serotonin and quipazine occurred 1 h after treatment. The quipazine-stimulated response was partly prevented by the serotonin antagonist cyproheptadine. Cockerels pretreated with dexamethasone, a synthetic steroid known to inhibit pituitary ACTH release, showed attenuated responses to subsequent quipazine, pargyline or serotonin injection. Serotonin, quipazine and cyproheptadine did not affect corticosterone release directly from the adrenal gland incubated in vitro, nor did they affect adrenal responsiveness to ACTH stimulation. The neurotoxin 5,6-dihydroxytryptamine injected into day-old chicks decreased plasma concentrations of corticosterone for up to 7 days after treatment, with corresponding decreases in the hypothalamic concentration of serotonin, but not dopamine or noradrenaline concentrations. These results show that adrenal corticosterone secretion is regulated by a central serotoninergic system, probably acting on the hypothalamo-pituitary-adrenal axis.
Persistent Identifierhttp://hdl.handle.net/10722/148866
ISSN
2015 Impact Factor: 4.498
2015 SCImago Journal Rankings: 1.910
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, Aen_US
dc.contributor.authorHall, TRen_US
dc.contributor.authorHarvey, Sen_US
dc.date.accessioned2012-06-20T06:15:47Z-
dc.date.available2012-06-20T06:15:47Z-
dc.date.issued1987en_US
dc.identifier.citationJournal Of Endocrinology, 1987, v. 113 n. 2, p. 159-165en_US
dc.identifier.issn0022-0795en_US
dc.identifier.urihttp://hdl.handle.net/10722/148866-
dc.description.abstractThe effects of serotoninergic drugs on adrenocortical function in domestic fowl were examined. Administration of the serotonin receptor agonist 2-(1-piperazinyl)quinoline maleate (quipazine), an inhibitor of serotonin metabolism, N-methyl-N-2-propynylbenzylamine HCl (pargyline), as well as serotonin itself, all increased plasma concentrations of corticosterone. The maximum responses to serotonin and quipazine occurred 1 h after treatment. The quipazine-stimulated response was partly prevented by the serotonin antagonist cyproheptadine. Cockerels pretreated with dexamethasone, a synthetic steroid known to inhibit pituitary ACTH release, showed attenuated responses to subsequent quipazine, pargyline or serotonin injection. Serotonin, quipazine and cyproheptadine did not affect corticosterone release directly from the adrenal gland incubated in vitro, nor did they affect adrenal responsiveness to ACTH stimulation. The neurotoxin 5,6-dihydroxytryptamine injected into day-old chicks decreased plasma concentrations of corticosterone for up to 7 days after treatment, with corresponding decreases in the hypothalamic concentration of serotonin, but not dopamine or noradrenaline concentrations. These results show that adrenal corticosterone secretion is regulated by a central serotoninergic system, probably acting on the hypothalamo-pituitary-adrenal axis.en_US
dc.languageengen_US
dc.publisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.orgen_US
dc.relation.ispartofJournal of Endocrinologyen_US
dc.subject.mesh5,6-Dihydroxytryptamine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickens - Physiologyen_US
dc.subject.meshCorticosterone - Secretionen_US
dc.subject.meshCyproheptadine - Pharmacologyen_US
dc.subject.meshDexamethasone - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshQuipazine - Pharmacologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.titleSerotoninergic regulation of corticosterone secretion in domestic fowlen_US
dc.typeArticleen_US
dc.identifier.emailCheung, A:lmcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, A=rp00332en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3585229-
dc.identifier.scopuseid_2-s2.0-0023189220en_US
dc.identifier.volume113en_US
dc.identifier.issue2en_US
dc.identifier.spage159en_US
dc.identifier.epage165en_US
dc.identifier.isiWOS:A1987H215100002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, A=8323783300en_US
dc.identifier.scopusauthoridHall, TR=7402483718en_US
dc.identifier.scopusauthoridHarvey, S=7202020846en_US

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