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Article: Measurement of neuropeptides in the brain and spinal cord of Wobbler mouse: A model for motoneuron disease

TitleMeasurement of neuropeptides in the brain and spinal cord of Wobbler mouse: A model for motoneuron disease
Authors
Keywordsenkephalin
motoneuron disease
radioassay
somatostatin
substance P
thyrotropin releasing hormone
Wobbler mice
Issue Date1990
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1990, v. 518 n. 1-2, p. 329-333 How to Cite?
AbstractThe Wobbler mouse (wr) exhibits the loss of motoneurons especially in the cervical spinal cord, and thus has been studied as a model for human motoneuron diseases. Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla). Enkephalins (methionine and leucine) also increase in the spinal cord and brainstem. Somatostatin increases in hypothalamus, perhaps accounting partly for the small size of this mutant mouse via its effect on growth hormone.
Persistent Identifierhttp://hdl.handle.net/10722/148859
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_HK
dc.contributor.authorCheung, Aen_HK
dc.contributor.authorVaccaGalloway, LLen_HK
dc.date.accessioned2012-06-20T01:58:39Z-
dc.date.available2012-06-20T01:58:39Z-
dc.date.issued1990en_HK
dc.identifier.citationBrain Research, 1990, v. 518 n. 1-2, p. 329-333en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148859-
dc.description.abstractThe Wobbler mouse (wr) exhibits the loss of motoneurons especially in the cervical spinal cord, and thus has been studied as a model for human motoneuron diseases. Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla). Enkephalins (methionine and leucine) also increase in the spinal cord and brainstem. Somatostatin increases in hypothalamus, perhaps accounting partly for the small size of this mutant mouse via its effect on growth hormone.en_HK
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain Research, [VOL 518, ISSUE 1-2, 1990] DOI 10.1016/0006-8993(90)90992-K-
dc.subjectenkephalinen_HK
dc.subjectmotoneuron diseaseen_HK
dc.subjectradioassayen_HK
dc.subjectsomatostatinen_HK
dc.subjectsubstance Pen_HK
dc.subjectthyrotropin releasing hormoneen_HK
dc.subjectWobbler miceen_HK
dc.subject.meshBrain - growth and development-
dc.subject.meshMotor Neurons - physiology-
dc.subject.meshNeuromuscular Diseases - physiopathology-
dc.subject.meshNeuropeptides - analysis-
dc.subject.meshSpinal Cord - analysis - growth and development-
dc.titleMeasurement of neuropeptides in the brain and spinal cord of Wobbler mouse: A model for motoneuron diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.emailCheung, A: lmcheung@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.identifier.authorityCheung, A=rp00332en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0006-8993(90)90992-Ken_HK
dc.identifier.pmid1697212-
dc.identifier.scopuseid_2-s2.0-0025309375en_HK
dc.identifier.volume518en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage329en_HK
dc.identifier.epage333en_HK
dc.identifier.isiWOS:A1990DP39300048-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridCheung, A=7401806497en_HK
dc.identifier.scopusauthoridVaccaGalloway, LL=6602468305en_HK

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