Article: Adiposity, its related biologic risk factors, and suicide: a cohort study of 542,088 Taiwanese adults
| Title | Adiposity, its related biologic risk factors, and suicide: a cohort study of 542,088 Taiwanese adults | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Chang, SS1 3 5 Wen, CP2 4 Tsai, MK2 4 Lawlor, DA5 Yang, YC2 4 Gunnell, D5 | ||||||||||
| Issue Date | 2012 | ||||||||||
| Publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ | ||||||||||
| Citation | American Journal of Epidemiology, 2012, v. 175 n. 8, p. 804-815 [How to Cite?] DOI: http://dx.doi.org/10.1093/aje/kwr386 | ||||||||||
| Abstract | Recent studies in Western nations have shown inverse associations between body mass index (BMI, measured as weight (kg)/height (m)(2)) and suicide. However, it is uncertain whether the association is similar in non-Western settings, and the biologic pathways underlying the association are unclear. The authors investigated these issues in a cohort of 542,088 Taiwanese people 20 years of age or older who participated in a health check-up program (1994-2008); there were 573 suicides over a mean 8.1 years of follow up. There was a J-shaped association between BMI and suicide risk (P for the quadratic term = 0.033) but limited evidence of a linear association (adjusted hazard ratio per 1-standard-deviation increase = 0.95 (95% confidence interval: 0.85, 1.06)); compared with individuals whose BMI was 18.5-22.9, adjusted hazard ratios for those with a BMI <18.5 or >/=35 were 1.56 (95% confidence interval: 1.07, 2.28) and 3.62 (95% confidence interval: 1.59, 8.22), respectively. A high waist-to-hip ratio was associated with an increased risk of suicide. There was some evidence for a reverse J-shaped association of systolic blood pressure and high density lipoprotein cholesterol with suicide and an association of higher triglyceride level with increased suicide risk; these associations did not appear to mediate the associations of BMI and waist-to-hip ratio with suicide. | ||||||||||
| ISSN | 0002-9262 2011 Impact Factor: 5.216 2011 SCImago Journal Rankings: 0.526 | ||||||||||
| DOI | http://dx.doi.org/10.1093/aje/kwr386 | ||||||||||
| ISI Accession Number ID | WOS:000302806300010
Funding Information: This study was in part supported by a grant from the Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004) and institutional support from the National Health Research Institutes, Taiwan. Dr. Shu-Sen Chang's fellowship is funded by the National Science Council, Taiwan (NSC-98-2917-I-564-162). Dr. David Gunnell is a United Kingdom National Institute for Health Research Senior Investigator. Dr. Debbie A. Lawlor works in a center that receives support from the United Kingdom Medical Research Council (grant G0600705) and the University of Bristol. | ||||||||||
| References | References in Scopus |
| dc.contributor.author | Chang, SS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Wen, CP | ||||||||||
| dc.contributor.author | Tsai, MK | ||||||||||
| dc.contributor.author | Lawlor, DA | ||||||||||
| dc.contributor.author | Yang, YC | ||||||||||
| dc.contributor.author | Gunnell, D | ||||||||||
| dc.date.accessioned | 2012-06-15T03:51:54Z | ||||||||||
| dc.date.available | 2012-06-15T03:51:54Z | ||||||||||
| dc.date.issued | 2012 | ||||||||||
| dc.description.abstract | Recent studies in Western nations have shown inverse associations between body mass index (BMI, measured as weight (kg)/height (m)(2)) and suicide. However, it is uncertain whether the association is similar in non-Western settings, and the biologic pathways underlying the association are unclear. The authors investigated these issues in a cohort of 542,088 Taiwanese people 20 years of age or older who participated in a health check-up program (1994-2008); there were 573 suicides over a mean 8.1 years of follow up. There was a J-shaped association between BMI and suicide risk (P for the quadratic term = 0.033) but limited evidence of a linear association (adjusted hazard ratio per 1-standard-deviation increase = 0.95 (95% confidence interval: 0.85, 1.06)); compared with individuals whose BMI was 18.5-22.9, adjusted hazard ratios for those with a BMI <18.5 or >/=35 were 1.56 (95% confidence interval: 1.07, 2.28) and 3.62 (95% confidence interval: 1.59, 8.22), respectively. A high waist-to-hip ratio was associated with an increased risk of suicide. There was some evidence for a reverse J-shaped association of systolic blood pressure and high density lipoprotein cholesterol with suicide and an association of higher triglyceride level with increased suicide risk; these associations did not appear to mediate the associations of BMI and waist-to-hip ratio with suicide. | ||||||||||
| dc.description.nature | postprint | ||||||||||
| dc.identifier.citation | American Journal of Epidemiology, 2012, v. 175 n. 8, p. 804-815 [How to Cite?] DOI: http://dx.doi.org/10.1093/aje/kwr386 | ||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1093/aje/kwr386 | ||||||||||
| dc.identifier.epage | 815 | ||||||||||
| dc.identifier.hkuros | 211095 | ||||||||||
| dc.identifier.isi | WOS:000302806300010
Funding Information: This study was in part supported by a grant from the Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004) and institutional support from the National Health Research Institutes, Taiwan. Dr. Shu-Sen Chang's fellowship is funded by the National Science Council, Taiwan (NSC-98-2917-I-564-162). Dr. David Gunnell is a United Kingdom National Institute for Health Research Senior Investigator. Dr. Debbie A. Lawlor works in a center that receives support from the United Kingdom Medical Research Council (grant G0600705) and the University of Bristol. | ||||||||||
| dc.identifier.issn | 0002-9262 2011 Impact Factor: 5.216 2011 SCImago Journal Rankings: 0.526 | ||||||||||
| dc.identifier.issue | 8 | ||||||||||
| dc.identifier.pmid | 22427611 | ||||||||||
| dc.identifier.scopus | eid_2-s2.0-84859710614 | ||||||||||
| dc.identifier.spage | 804 | ||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/148854 | ||||||||||
| dc.identifier.volume | 175 | ||||||||||
| dc.language | eng | ||||||||||
| dc.publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ | ||||||||||
| dc.publisher.place | United States | ||||||||||
| dc.relation.ispartof | American Journal of Epidemiology | ||||||||||
| dc.relation.references | References in Scopus | ||||||||||
| dc.rights | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Epidemiology following peer review. The definitive publisher-authenticated version American Journal of Epidemiology, 2012, v. 175 n. 8, p. 804-815 is available online at: http://aje.oxfordjournals.org/content/175/8/804 | ||||||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||||||
| dc.subject.mesh | Adiposity | ||||||||||
| dc.subject.mesh | Blood Pressure | ||||||||||
| dc.subject.mesh | Body Mass Index | ||||||||||
| dc.subject.mesh | Cholesterol - blood | ||||||||||
| dc.subject.mesh | Suicide - statistics and numerical data | ||||||||||
| dc.title | Adiposity, its related biologic risk factors, and suicide: a cohort study of 542,088 Taiwanese adults | ||||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- China Medical University Hospital Taichung
- Ju Shan Hospital
- National Health Research Institutes Taiwan
- University of Bristol