File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Evaluation of moderate alcohol use and cognitive function among men using a mendelian randomization design in the guangzhou biobank cohort study
  • Basic View
  • Metadata View
  • XML View
TitleEvaluation of moderate alcohol use and cognitive function among men using a mendelian randomization design in the guangzhou biobank cohort study
 
AuthorsAu Yeung, SL
Jiang, CQ
Cheng, KK
Liu, B
Zhang, WS
Lam, TH1
Leung, GM
Schooling, CM
 
Keywordsalcohol drinking
cognition
developing countries
Mendelian randomization analysis
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
 
CitationAmerican Journal Of Epidemiology, 2012, v. 175 n. 10, p. 1021-1028 [How to Cite?]
DOI: http://dx.doi.org/10.1093/aje/kwr462
 
AbstractObservational studies usually show that moderate alcohol use is associated with better cognitive function. Such studies are vulnerable to residual confounding arising from systematic differences between moderate alcohol users and others. A Mendelian randomization study carried out in a suitable population, such as southern Chinese men, in which alcohol use is low to moderate and is influenced by genotype, offers an alternative and superior approach for clarifying the causal effect of moderate alcohol use on cognitive function. The authors used aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis to obtain unbiased estimates of the relation of alcohol consumption (measured in alcohol units (10 g ethanol) per day) with cognitive function, assessed from delayed 10-word recall score (n = 4,707) and Mini-Mental State Examination (MMSE) score (n = 2,284), among men from the Guangzhou Biobank Cohort Study (2003-2008). ALHD2 genotype was strongly associated with alcohol consumption, with an F statistic of 71.0 in 2-stage least squares analysis. Alcohol consumption was not associated with delayed 10-word recall score (-0.03 words per alcohol unit, 95% confidence interval:-0.18, 0.13) or MMSE score (0.06 points per alcohol unit, 95% confidence interval:-0.22, 0.34). Moderate alcohol use is unlikely to be cognitively protective. © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
 
ISSN0002-9262
2013 Impact Factor: 4.975
 
DOIhttp://dx.doi.org/10.1093/aje/kwr462
 
ISI Accession Number IDWOS:000304199000007
Funding AgencyGrant Number
Hong Kong Health and Health Services06070981
Health, Welfare and Food Bureau, Government of Hong Kong SAR, People's Republic of China
University of Hong Kong Foundation for Development and Research (Hong Kong, China)
University of Hong Kong University Research Committee (Hong Kong, China)
Guangzhou Public Health Bureau (Guangzhou, China)
Guangzhou Science and Technology Bureau (Guangzhou, China)
University of Birmingham (Birmingham, United Kingdom)
Natural Science Foundation of Guangdong (Guangdong, China)9451062001003477
Funding Information:

This study was supported by the Hong Kong Health and Health Services Research Fund (grant 06070981), Health, Welfare and Food Bureau, Government of Hong Kong SAR, People's Republic of China. The Guangzhou Biobank Cohort Study was funded by the University of Hong Kong Foundation for Development and Research (Hong Kong, China), the University of Hong Kong University Research Committee-Strategic Research Theme of Public Health (Hong Kong, China), the Guangzhou Public Health Bureau (Guangzhou, China), the Guangzhou Science and Technology Bureau (Guangzhou, China), the University of Birmingham (Birmingham, United Kingdom), and the Natural Science Foundation of Guangdong (Guangdong, China) (grant 9451062001003477).

 
ReferencesReferences in Scopus
 
GrantsIs moderate alcohol use causally protective against cardiorespiratory disease?
 
DC FieldValue
dc.contributor.authorAu Yeung, SL
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorCheng, KK
 
dc.contributor.authorLiu, B
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorSchooling, CM
 
dc.date.accessioned2012-06-12T01:00:24Z
 
dc.date.available2012-06-12T01:00:24Z
 
dc.date.issued2012
 
dc.description.abstractObservational studies usually show that moderate alcohol use is associated with better cognitive function. Such studies are vulnerable to residual confounding arising from systematic differences between moderate alcohol users and others. A Mendelian randomization study carried out in a suitable population, such as southern Chinese men, in which alcohol use is low to moderate and is influenced by genotype, offers an alternative and superior approach for clarifying the causal effect of moderate alcohol use on cognitive function. The authors used aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis to obtain unbiased estimates of the relation of alcohol consumption (measured in alcohol units (10 g ethanol) per day) with cognitive function, assessed from delayed 10-word recall score (n = 4,707) and Mini-Mental State Examination (MMSE) score (n = 2,284), among men from the Guangzhou Biobank Cohort Study (2003-2008). ALHD2 genotype was strongly associated with alcohol consumption, with an F statistic of 71.0 in 2-stage least squares analysis. Alcohol consumption was not associated with delayed 10-word recall score (-0.03 words per alcohol unit, 95% confidence interval:-0.18, 0.13) or MMSE score (0.06 points per alcohol unit, 95% confidence interval:-0.22, 0.34). Moderate alcohol use is unlikely to be cognitively protective. © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
 
dc.description.naturepostprint
 
dc.identifier.citationAmerican Journal Of Epidemiology, 2012, v. 175 n. 10, p. 1021-1028 [How to Cite?]
DOI: http://dx.doi.org/10.1093/aje/kwr462
 
dc.identifier.doihttp://dx.doi.org/10.1093/aje/kwr462
 
dc.identifier.eissn1476-6256
 
dc.identifier.epage1028
 
dc.identifier.hkuros199848
 
dc.identifier.isiWOS:000304199000007
Funding AgencyGrant Number
Hong Kong Health and Health Services06070981
Health, Welfare and Food Bureau, Government of Hong Kong SAR, People's Republic of China
University of Hong Kong Foundation for Development and Research (Hong Kong, China)
University of Hong Kong University Research Committee (Hong Kong, China)
Guangzhou Public Health Bureau (Guangzhou, China)
Guangzhou Science and Technology Bureau (Guangzhou, China)
University of Birmingham (Birmingham, United Kingdom)
Natural Science Foundation of Guangdong (Guangdong, China)9451062001003477
Funding Information:

This study was supported by the Hong Kong Health and Health Services Research Fund (grant 06070981), Health, Welfare and Food Bureau, Government of Hong Kong SAR, People's Republic of China. The Guangzhou Biobank Cohort Study was funded by the University of Hong Kong Foundation for Development and Research (Hong Kong, China), the University of Hong Kong University Research Committee-Strategic Research Theme of Public Health (Hong Kong, China), the Guangzhou Public Health Bureau (Guangzhou, China), the Guangzhou Science and Technology Bureau (Guangzhou, China), the University of Birmingham (Birmingham, United Kingdom), and the Natural Science Foundation of Guangdong (Guangdong, China) (grant 9451062001003477).

 
dc.identifier.issn0002-9262
2013 Impact Factor: 4.975
 
dc.identifier.issue10
 
dc.identifier.pmid22302076
 
dc.identifier.scopuseid_2-s2.0-84861360012
 
dc.identifier.spage1021
 
dc.identifier.urihttp://hdl.handle.net/10722/148838
 
dc.identifier.volume175
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Epidemiology
 
dc.relation.projectIs moderate alcohol use causally protective against cardiorespiratory disease?
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Epidemiology following peer review. The definitive publisher-authenticated version American Journal Of Epidemiology, 2012, v. 175 n. 10, p. 1021-1028 is available online at: http://aje.oxfordjournals.org/content/175/10/1021
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectalcohol drinking
 
dc.subjectcognition
 
dc.subjectdeveloping countries
 
dc.subjectMendelian randomization analysis
 
dc.titleEvaluation of moderate alcohol use and cognitive function among men using a mendelian randomization design in the guangzhou biobank cohort study
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Au Yeung, SL</contributor.author>
<contributor.author>Jiang, CQ</contributor.author>
<contributor.author>Cheng, KK</contributor.author>
<contributor.author>Liu, B</contributor.author>
<contributor.author>Zhang, WS</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Leung, GM</contributor.author>
<contributor.author>Schooling, CM</contributor.author>
<date.accessioned>2012-06-12T01:00:24Z</date.accessioned>
<date.available>2012-06-12T01:00:24Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>American Journal Of Epidemiology, 2012, v. 175 n. 10, p. 1021-1028</identifier.citation>
<identifier.issn>0002-9262</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/148838</identifier.uri>
<description.abstract>Observational studies usually show that moderate alcohol use is associated with better cognitive function. Such studies are vulnerable to residual confounding arising from systematic differences between moderate alcohol users and others. A Mendelian randomization study carried out in a suitable population, such as southern Chinese men, in which alcohol use is low to moderate and is influenced by genotype, offers an alternative and superior approach for clarifying the causal effect of moderate alcohol use on cognitive function. The authors used aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis to obtain unbiased estimates of the relation of alcohol consumption (measured in alcohol units (10 g ethanol) per day) with cognitive function, assessed from delayed 10-word recall score (n = 4,707) and Mini-Mental State Examination (MMSE) score (n = 2,284), among men from the Guangzhou Biobank Cohort Study (2003-2008). ALHD2 genotype was strongly associated with alcohol consumption, with an F statistic of 71.0 in 2-stage least squares analysis. Alcohol consumption was not associated with delayed 10-word recall score (-0.03 words per alcohol unit, 95% confidence interval:-0.18, 0.13) or MMSE score (0.06 points per alcohol unit, 95% confidence interval:-0.22, 0.34). Moderate alcohol use is unlikely to be cognitively protective. &#169; The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://aje.oxfordjournals.org/</publisher>
<relation.ispartof>American Journal of Epidemiology</relation.ispartof>
<rights>This is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Epidemiology following peer review. The definitive publisher-authenticated version American Journal Of Epidemiology, 2012, v. 175 n. 10, p. 1021-1028 is available online at: http://aje.oxfordjournals.org/content/175/10/1021</rights>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<subject>alcohol drinking</subject>
<subject>cognition</subject>
<subject>developing countries</subject>
<subject>Mendelian randomization analysis</subject>
<title>Evaluation of moderate alcohol use and cognitive function among men using a mendelian randomization design in the guangzhou biobank cohort study</title>
<type>Article</type>
<description.nature>postprint</description.nature>
<identifier.doi>10.1093/aje/kwr462</identifier.doi>
<identifier.pmid>22302076</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84861360012</identifier.scopus>
<identifier.hkuros>199848</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84861360012&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>175</identifier.volume>
<identifier.issue>10</identifier.issue>
<identifier.spage>1021</identifier.spage>
<identifier.epage>1028</identifier.epage>
<identifier.eissn>1476-6256</identifier.eissn>
<identifier.isi>WOS:000304199000007</identifier.isi>
<publisher.place>United States</publisher.place>
<relation.project>Is moderate alcohol use causally protective against cardiorespiratory disease?</relation.project>
<bitstream.url>http://hub.hku.hk/bitstream/10722/148838/2/Content.pdf</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine