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Article: Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma

TitleOverexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma
Authors
KeywordsESCC
MMP10
Overexpression
Prognosis
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DES
Citation
Diseases Of The Esophagus, 2012, v. 25 n. 7, p. 656-663 How to Cite?
AbstractMatrix metallopeptidase 10 (MMP10) is frequently expressed and correlates closely with metastasis and poor prognosis in various human cancers. However, the significance of MMP10 expression in esophageal squamous cell carcinoma (ESCC) and its role in ESCC progression remains unclear. In this report, upregulation of MMP10 mRNA was detected in 39/60 (65.0%) of primary ESCC tissues compared with their paired nontumor esophageal tissues. Tissue microarray (TMA) study found protein overexpression of MMP10 in 188/239 (78.7%) of primary ESCC tissues but not in their corresponding nontumor esophageal tissues, suggesting that overexpression of MMP10 may play important roles in ESCC development and progression. Although the overexpression of MMP10 was not significantly associated with disease-specific survival rate (P= 0.182) for all tested ESCCs, it was significantly associated with poorer disease-specific survival (P= 0.001) in early stage of ESCCs (I-IIA). In addition, multivariate analysis found that MMP10 expression in tumor tissues was evaluated as a potential independent prognostic factor for early stage ESCC patients. These findings suggest that MMP10 plays an important role in ESCC progression in the early stage, and overexpression of MMP10 in tumor tissues could be used as a potential prognostic marker for patients with early clinical stage of ESCC. © 2011 Copyright the Authors. Journal compilation © 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.
Persistent Identifierhttp://hdl.handle.net/10722/148754
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.760
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Hen_US
dc.contributor.authorQin, YRen_US
dc.contributor.authorBi, Jen_US
dc.contributor.authorGuo, Aen_US
dc.contributor.authorFu, Len_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-06-06T05:36:12Z-
dc.date.available2012-06-06T05:36:12Z-
dc.date.issued2012en_US
dc.identifier.citationDiseases Of The Esophagus, 2012, v. 25 n. 7, p. 656-663en_US
dc.identifier.issn1120-8694en_US
dc.identifier.urihttp://hdl.handle.net/10722/148754-
dc.description.abstractMatrix metallopeptidase 10 (MMP10) is frequently expressed and correlates closely with metastasis and poor prognosis in various human cancers. However, the significance of MMP10 expression in esophageal squamous cell carcinoma (ESCC) and its role in ESCC progression remains unclear. In this report, upregulation of MMP10 mRNA was detected in 39/60 (65.0%) of primary ESCC tissues compared with their paired nontumor esophageal tissues. Tissue microarray (TMA) study found protein overexpression of MMP10 in 188/239 (78.7%) of primary ESCC tissues but not in their corresponding nontumor esophageal tissues, suggesting that overexpression of MMP10 may play important roles in ESCC development and progression. Although the overexpression of MMP10 was not significantly associated with disease-specific survival rate (P= 0.182) for all tested ESCCs, it was significantly associated with poorer disease-specific survival (P= 0.001) in early stage of ESCCs (I-IIA). In addition, multivariate analysis found that MMP10 expression in tumor tissues was evaluated as a potential independent prognostic factor for early stage ESCC patients. These findings suggest that MMP10 plays an important role in ESCC progression in the early stage, and overexpression of MMP10 in tumor tissues could be used as a potential prognostic marker for patients with early clinical stage of ESCC. © 2011 Copyright the Authors. Journal compilation © 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DESen_US
dc.relation.ispartofDiseases of the Esophagusen_US
dc.subjectESCCen_US
dc.subjectMMP10en_US
dc.subjectOverexpressionen_US
dc.subjectPrognosisen_US
dc.titleOverexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailFu, L:gracefu@graduate.hku.hken_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityFu, L=rp01435en_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1442-2050.2011.01284.xen_US
dc.identifier.pmid22121946-
dc.identifier.scopuseid_2-s2.0-84866265383en_US
dc.identifier.hkuros203490-
dc.identifier.isiWOS:000308712300013-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLiu, H=54407064600en_US
dc.identifier.scopusauthoridQin, YR=7403100680en_US
dc.identifier.scopusauthoridBi, J=7103093361en_US
dc.identifier.scopusauthoridGuo, A=12793848000en_US
dc.identifier.scopusauthoridFu, L=22979236700en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US

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