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Article: A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?

TitleA secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?
Authors
Issue Date2012
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2012, v. 51 n. 9, p. 2221-2224 How to Cite?
AbstractOne flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/148687
ISSN
2015 Impact Factor: 11.709
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID
Funding AgencyGrant Number
Australian Research Council
National Health and Medical Research Council
Research Grants Council, Hong KongGRF774109
AoE/M-12/06
Funding Information:

We gratefully acknowledge the financial support of the Australian Research Council, the National Health and Medical Research Council, and the Research Grants Council, Hong Kong (GRF774109 and AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLai, JCCen_HK
dc.contributor.authorGarcia, JMen_HK
dc.contributor.authorDyason, JCen_HK
dc.contributor.authorBöhm, Ren_HK
dc.contributor.authorMadge, PDen_HK
dc.contributor.authorRose, FJen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorHaselhorst, Ten_HK
dc.contributor.authorvon Itzstein, Men_HK
dc.date.accessioned2012-05-29T06:14:41Z-
dc.date.available2012-05-29T06:14:41Z-
dc.date.issued2012en_HK
dc.identifier.citationAngewandte Chemie (International Edition), 2012, v. 51 n. 9, p. 2221-2224en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148687-
dc.description.abstractOne flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie (International Edition)en_HK
dc.subject.meshN-Acetylneuraminic Acid - metabolism-
dc.subject.meshNeuraminidase - chemistry - metabolism-
dc.subject.meshNuclear Magnetic Resonance, Biomolecular-
dc.subject.meshOrthomyxoviridae - chemistry - enzymology-
dc.subject.meshOseltamivir - pharmacology-
dc.titleA secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?en_HK
dc.typeArticleen_HK
dc.identifier.emailLai, JCC: jimmylcc@hku.hken_HK
dc.identifier.emailGarcia, JM: jmgarcia@hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/anie.201108245en_HK
dc.identifier.pmid22281708-
dc.identifier.scopuseid_2-s2.0-84863393284en_HK
dc.identifier.hkuros205825-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863393284&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2221en_HK
dc.identifier.epage2224en_HK
dc.identifier.isiWOS:000300691900042-
dc.publisher.placeGermanyen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridVonItzstein, M=7005568103en_HK
dc.identifier.scopusauthoridHaselhorst, T=7801651226en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridRose, FJ=7102651584en_HK
dc.identifier.scopusauthoridMadge, PD=16066982600en_HK
dc.identifier.scopusauthoridBöhm, R=36463132000en_HK
dc.identifier.scopusauthoridDyason, JC=6506756876en_HK
dc.identifier.scopusauthoridGarcia, JM=16202601400en_HK
dc.identifier.scopusauthoridLai, JCC=24066794100en_HK

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