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Article: A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia-evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients

TitleA single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia-evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients
Authors
KeywordsAcute Myeloid Leukemia
Acute Promyelocytic Leukemia
Chinese
Cytogenetics
Prevalence
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.cancergeneticsjournal.org
Citation
Cancer Genetics, 2011, v. 204 n. 8, p. 430-438 How to Cite?
AbstractCytogenetic information is important in the diagnosis, classification, and prognostication of acute myeloid leukemia (AML). Data obtained from multicenter treatment trials are well published. In this study, we contribute cytogenetic data from a large series of 629 Chinese patients with de novo AML that were karyotyped in a single laboratory. A higher prevalence of acute promyelocytic leukemia was observed when compared with non-Chinese series. The difference was most prominent in the younger age group. Abnormalities at chromosomal region 11q23 and inv(16) seemed uncommon. These ethnic differences may indicate underlying genetic susceptibility to AML development and/or environmental differences. More comprehensive data on AML in the elder population are needed to assess the role of cytogenetics in predicting prognosis and guiding treatment in this large subgroup of patients. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148681
ISSN
2015 Impact Factor: 2.333
2015 SCImago Journal Rankings: 1.290
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CCen_US
dc.contributor.authorWan, TSen_US
dc.contributor.authorChow, JLen_US
dc.contributor.authorHui, KCen_US
dc.contributor.authorChoi, WWen_US
dc.contributor.authorLam, CCen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:14:38Z-
dc.date.available2012-05-29T06:14:38Z-
dc.date.issued2011en_US
dc.identifier.citationCancer Genetics, 2011, v. 204 n. 8, p. 430-438en_US
dc.identifier.issn2210-7762en_US
dc.identifier.urihttp://hdl.handle.net/10722/148681-
dc.description.abstractCytogenetic information is important in the diagnosis, classification, and prognostication of acute myeloid leukemia (AML). Data obtained from multicenter treatment trials are well published. In this study, we contribute cytogenetic data from a large series of 629 Chinese patients with de novo AML that were karyotyped in a single laboratory. A higher prevalence of acute promyelocytic leukemia was observed when compared with non-Chinese series. The difference was most prominent in the younger age group. Abnormalities at chromosomal region 11q23 and inv(16) seemed uncommon. These ethnic differences may indicate underlying genetic susceptibility to AML development and/or environmental differences. More comprehensive data on AML in the elder population are needed to assess the role of cytogenetics in predicting prognosis and guiding treatment in this large subgroup of patients. © 2011 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.cancergeneticsjournal.org-
dc.relation.ispartofCancer Geneticsen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectAcute Promyelocytic Leukemiaen_US
dc.subjectChineseen_US
dc.subjectCytogeneticsen_US
dc.subjectPrevalenceen_US
dc.titleA single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia-evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patientsen_US
dc.typeArticleen_US
dc.identifier.emailSo, CC:scc@pathology.hku.hken_US
dc.identifier.authoritySo, CC=rp00391en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cancergen.2011.06.003en_US
dc.identifier.pmid21962893-
dc.identifier.scopuseid_2-s2.0-84856380385en_US
dc.identifier.hkuros201258-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856380385&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume204en_US
dc.identifier.issue8en_US
dc.identifier.spage430en_US
dc.identifier.epage438en_US
dc.identifier.eissn2210-7770-
dc.identifier.isiWOS:000295905300003-
dc.publisher.placeUnited States-

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