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Article: Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential

TitlePathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential
Authors
KeywordsAtypical Leiomyoma
Epithelioid Leiomyosarcoma
Myxoid Leiomyosarcoma
Stump
Uterine Leiomyosarcoma
Uterine Smooth Muscle Tumour Of Uncertain Malignant Potential
Issue Date2011
PublisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn
Citation
Best Practice And Research: Clinical Obstetrics And Gynaecology, 2011, v. 25 n. 6, p. 691-704 How to Cite?
Abstract
Uterine leiomyosarcomas are the most common uterine sarcomas. For clinicians, they are difficult tumours to manage. Preoperative detection is difficult because of the similarity in clinical presentation to ordinary fibroids. They are highly aggressive tumours and the effectiveness of adjuvant therapy remains controversial with surgery remaining the mainstay of treatment. Despite treatment, disease frequently recurs. For pathologists, diagnosis of most leiomyosarcomas using current diagnostic criteria is usually straightforward, as most tumours often possess two or more diagnostic microscopic features, including diffuse atypia, high mitotic count and tumour cell necrosis. Diagnostic difficulties usually relate to tumours having only one of these worrisome features, with or without other additional unusual morphologic findings. These latter tumours have been labelled as uterine smooth-muscle tumours of uncertain malignant potential. Those that are followed by a recurrence are biologically low-grade leiomyosarcomas. Epithelioid and myxoid leiomyosarcomas are less common, and their diagnostic criteria are different to tumours of usual spindle cell differentiation. In this review, we discuss the pathology of leiomyosarcomas, including an update on smooth-muscle tumours of uncertain malignant potential, with emphasis on the controversy of labelling of atypical leiomyomas. The problems with histologic diagnosis, immunohistochemical studies and molecular pathology are reviewed. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148654
ISSN
2013 Impact Factor: 3.000
2013 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, PPCen_US
dc.contributor.authorCheung, ANYen_US
dc.date.accessioned2012-05-29T06:14:24Z-
dc.date.available2012-05-29T06:14:24Z-
dc.date.issued2011en_US
dc.identifier.citationBest Practice And Research: Clinical Obstetrics And Gynaecology, 2011, v. 25 n. 6, p. 691-704en_US
dc.identifier.issn1521-6934en_US
dc.identifier.urihttp://hdl.handle.net/10722/148654-
dc.description.abstractUterine leiomyosarcomas are the most common uterine sarcomas. For clinicians, they are difficult tumours to manage. Preoperative detection is difficult because of the similarity in clinical presentation to ordinary fibroids. They are highly aggressive tumours and the effectiveness of adjuvant therapy remains controversial with surgery remaining the mainstay of treatment. Despite treatment, disease frequently recurs. For pathologists, diagnosis of most leiomyosarcomas using current diagnostic criteria is usually straightforward, as most tumours often possess two or more diagnostic microscopic features, including diffuse atypia, high mitotic count and tumour cell necrosis. Diagnostic difficulties usually relate to tumours having only one of these worrisome features, with or without other additional unusual morphologic findings. These latter tumours have been labelled as uterine smooth-muscle tumours of uncertain malignant potential. Those that are followed by a recurrence are biologically low-grade leiomyosarcomas. Epithelioid and myxoid leiomyosarcomas are less common, and their diagnostic criteria are different to tumours of usual spindle cell differentiation. In this review, we discuss the pathology of leiomyosarcomas, including an update on smooth-muscle tumours of uncertain malignant potential, with emphasis on the controversy of labelling of atypical leiomyomas. The problems with histologic diagnosis, immunohistochemical studies and molecular pathology are reviewed. © 2011 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgynen_US
dc.relation.ispartofBest Practice and Research: Clinical Obstetrics and Gynaecologyen_US
dc.subjectAtypical Leiomyomaen_US
dc.subjectEpithelioid Leiomyosarcomaen_US
dc.subjectMyxoid Leiomyosarcomaen_US
dc.subjectStumpen_US
dc.subjectUterine Leiomyosarcomaen_US
dc.subjectUterine Smooth Muscle Tumour Of Uncertain Malignant Potentialen_US
dc.titlePathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potentialen_US
dc.typeArticleen_US
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_US
dc.identifier.authorityCheung, ANY=rp00542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bpobgyn.2011.07.003en_US
dc.identifier.pmid21865091-
dc.identifier.scopuseid_2-s2.0-80055057231en_US
dc.identifier.hkuros211351-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055057231&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.spage691en_US
dc.identifier.epage704en_US
dc.identifier.isiWOS:000297390600003-
dc.publisher.placeUnited Kingdomen_US

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