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Article: Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential
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TitlePathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential
 
AuthorsIp, PPC1
Cheung, ANY1
 
KeywordsAtypical Leiomyoma
Epithelioid Leiomyosarcoma
Myxoid Leiomyosarcoma
Stump
Uterine Leiomyosarcoma
Uterine Smooth Muscle Tumour Of Uncertain Malignant Potential
 
Issue Date2011
 
PublisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn
 
CitationBest Practice And Research: Clinical Obstetrics And Gynaecology, 2011, v. 25 n. 6, p. 691-704 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bpobgyn.2011.07.003
 
AbstractUterine leiomyosarcomas are the most common uterine sarcomas. For clinicians, they are difficult tumours to manage. Preoperative detection is difficult because of the similarity in clinical presentation to ordinary fibroids. They are highly aggressive tumours and the effectiveness of adjuvant therapy remains controversial with surgery remaining the mainstay of treatment. Despite treatment, disease frequently recurs. For pathologists, diagnosis of most leiomyosarcomas using current diagnostic criteria is usually straightforward, as most tumours often possess two or more diagnostic microscopic features, including diffuse atypia, high mitotic count and tumour cell necrosis. Diagnostic difficulties usually relate to tumours having only one of these worrisome features, with or without other additional unusual morphologic findings. These latter tumours have been labelled as uterine smooth-muscle tumours of uncertain malignant potential. Those that are followed by a recurrence are biologically low-grade leiomyosarcomas. Epithelioid and myxoid leiomyosarcomas are less common, and their diagnostic criteria are different to tumours of usual spindle cell differentiation. In this review, we discuss the pathology of leiomyosarcomas, including an update on smooth-muscle tumours of uncertain malignant potential, with emphasis on the controversy of labelling of atypical leiomyomas. The problems with histologic diagnosis, immunohistochemical studies and molecular pathology are reviewed. © 2011 Elsevier Ltd. All rights reserved.
 
ISSN1521-6934
2013 Impact Factor: 3.000
2013 SCImago Journal Rankings: 1.115
 
DOIhttp://dx.doi.org/10.1016/j.bpobgyn.2011.07.003
 
ISI Accession Number IDWOS:000297390600003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorIp, PPC
 
dc.contributor.authorCheung, ANY
 
dc.date.accessioned2012-05-29T06:14:24Z
 
dc.date.available2012-05-29T06:14:24Z
 
dc.date.issued2011
 
dc.description.abstractUterine leiomyosarcomas are the most common uterine sarcomas. For clinicians, they are difficult tumours to manage. Preoperative detection is difficult because of the similarity in clinical presentation to ordinary fibroids. They are highly aggressive tumours and the effectiveness of adjuvant therapy remains controversial with surgery remaining the mainstay of treatment. Despite treatment, disease frequently recurs. For pathologists, diagnosis of most leiomyosarcomas using current diagnostic criteria is usually straightforward, as most tumours often possess two or more diagnostic microscopic features, including diffuse atypia, high mitotic count and tumour cell necrosis. Diagnostic difficulties usually relate to tumours having only one of these worrisome features, with or without other additional unusual morphologic findings. These latter tumours have been labelled as uterine smooth-muscle tumours of uncertain malignant potential. Those that are followed by a recurrence are biologically low-grade leiomyosarcomas. Epithelioid and myxoid leiomyosarcomas are less common, and their diagnostic criteria are different to tumours of usual spindle cell differentiation. In this review, we discuss the pathology of leiomyosarcomas, including an update on smooth-muscle tumours of uncertain malignant potential, with emphasis on the controversy of labelling of atypical leiomyomas. The problems with histologic diagnosis, immunohistochemical studies and molecular pathology are reviewed. © 2011 Elsevier Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBest Practice And Research: Clinical Obstetrics And Gynaecology, 2011, v. 25 n. 6, p. 691-704 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bpobgyn.2011.07.003
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.bpobgyn.2011.07.003
 
dc.identifier.epage704
 
dc.identifier.hkuros211351
 
dc.identifier.isiWOS:000297390600003
 
dc.identifier.issn1521-6934
2013 Impact Factor: 3.000
2013 SCImago Journal Rankings: 1.115
 
dc.identifier.issue6
 
dc.identifier.pmid21865091
 
dc.identifier.scopuseid_2-s2.0-80055057231
 
dc.identifier.spage691
 
dc.identifier.urihttp://hdl.handle.net/10722/148654
 
dc.identifier.volume25
 
dc.languageeng
 
dc.publisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBest Practice and Research: Clinical Obstetrics and Gynaecology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAtypical Leiomyoma
 
dc.subjectEpithelioid Leiomyosarcoma
 
dc.subjectMyxoid Leiomyosarcoma
 
dc.subjectStump
 
dc.subjectUterine Leiomyosarcoma
 
dc.subjectUterine Smooth Muscle Tumour Of Uncertain Malignant Potential
 
dc.titlePathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong