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Article: Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: A clinicopathologic and molecular analysis

TitleIndolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: A clinicopathologic and molecular analysis
Authors
Keywordsallogeneic
autologous
haematopoietic SCT
indolent
T-cell large granular lymphocyte leukaemia
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2012, v. 47 n. 7, p. 952-956 How to Cite?
AbstractFour women and three men after allogeneic (n4) and autologous (n3) haematopoietic SCT (HSCT) were observed to have an increase in T-cell large granular lymphocytes (T-LGLs) of CD3CD8 phenotype for a median of 41 (15-118) months. Clonal rearrangement of the T-cell receptor gene was verified by two PCR techniques and direct DNA sequencing, confirming that the cases were neoplastic and therefore classifiable as T-LGL leukaemia. In the allogeneic HSCT cases, T-LGL leukaemia was derived from donor T cells in three patients, as shown by DNA chimerism analysis, and recipient T cells in one patient who had graft failure previously. None of the patients showed cytopenia, autoimmune phenomenon or organ infiltration, which were features typical of de novo T-LGL leukaemia. Six patients had remained asymptomatic with stable large granular lymphocyte counts. One patient died from cerebral relapse of the original lymphoma. T-LGL leukaemias occurring post-HSCT are distinct from de novo T-LGL leukaemia and may have a different pathogenesis and clinical course. Patients did not require specific treatment, and the disease remained stable for long periods. © 2012 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/148652
ISSN
2014 Impact Factor: 3.570
2013 SCImago Journal Rankings: 1.441
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGill, Hen_HK
dc.contributor.authorIp, AHWen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorSo, JCCen_HK
dc.contributor.authorPang, AWKen_HK
dc.contributor.authorTse, Een_HK
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-05-29T06:14:24Z-
dc.date.available2012-05-29T06:14:24Z-
dc.date.issued2012en_HK
dc.identifier.citationBone Marrow Transplantation, 2012, v. 47 n. 7, p. 952-956en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148652-
dc.description.abstractFour women and three men after allogeneic (n4) and autologous (n3) haematopoietic SCT (HSCT) were observed to have an increase in T-cell large granular lymphocytes (T-LGLs) of CD3CD8 phenotype for a median of 41 (15-118) months. Clonal rearrangement of the T-cell receptor gene was verified by two PCR techniques and direct DNA sequencing, confirming that the cases were neoplastic and therefore classifiable as T-LGL leukaemia. In the allogeneic HSCT cases, T-LGL leukaemia was derived from donor T cells in three patients, as shown by DNA chimerism analysis, and recipient T cells in one patient who had graft failure previously. None of the patients showed cytopenia, autoimmune phenomenon or organ infiltration, which were features typical of de novo T-LGL leukaemia. Six patients had remained asymptomatic with stable large granular lymphocyte counts. One patient died from cerebral relapse of the original lymphoma. T-LGL leukaemias occurring post-HSCT are distinct from de novo T-LGL leukaemia and may have a different pathogenesis and clinical course. Patients did not require specific treatment, and the disease remained stable for long periods. © 2012 Macmillan Publishers Limited.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectallogeneicen_HK
dc.subjectautologousen_HK
dc.subjecthaematopoietic SCTen_HK
dc.subjectindolenten_HK
dc.subjectT-cell large granular lymphocyte leukaemiaen_HK
dc.titleIndolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: A clinicopathologic and molecular analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailTse, E:ewctse@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/bmt.2011.212en_HK
dc.identifier.pmid22041849-
dc.identifier.scopuseid_2-s2.0-84863721430en_HK
dc.identifier.hkuros205184-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863721430&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue7en_HK
dc.identifier.spage952en_HK
dc.identifier.epage956en_HK
dc.identifier.isiWOS:000306113100008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGill, H=36086184900en_HK
dc.identifier.scopusauthoridIp, AHW=55200628500en_HK
dc.identifier.scopusauthoridLeung, R=23970867600en_HK
dc.identifier.scopusauthoridSo, JCC=55311297500en_HK
dc.identifier.scopusauthoridPang, AWK=7007044165en_HK
dc.identifier.scopusauthoridTse, E=7005019454en_HK
dc.identifier.scopusauthoridLeung, AYH=55263121300en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.citeulike9986536-

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