File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Recurrent triploid and dispermic conceptions in patients with NLRP7 mutations

TitleRecurrent triploid and dispermic conceptions in patients with NLRP7 mutations
Authors
Issue Date2011
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placenta
Citation
Placenta, 2011, v. 32 n. 5, p. 409-412 How to Cite?
AbstractTo understand the mechanisms leading to hydatidiform mole formation in patients with NLRP7 mutations, we used a combination of various approaches to characterize five products of conception, from two patients, shown by flow cytometry to contain non-diploid cells. We demonstrate that four of these conceptions are triploid and two of them originated from fertilization with more than one sperm. We show that three of these triploid conceptions fulfill the histopathological criteria of partial hydatidiform mole and one fulfills the histopathological criteria of spontaneous abortion. Our data demonstrate that some oocytes from one patient with NLRP7 mutations are not able to prevent polyspermic fertilization and highlight the importance of using several approaches to characterize the genetic complexity of molar tissues and reproductive wastage. Altogether, our previous and current data show the association of NLRP7 mutations with several types of hydatidiform moles and with triploid spontaneous abortions. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148638
ISSN
2015 Impact Factor: 2.972
2015 SCImago Journal Rankings: 1.608
ISI Accession Number ID
Funding AgencyGrant Number
Canadian Institute of Health ResearchMOP 86546
Fonds de Recherche en Sante du Quebec
Funding Information:

We thank the patients and their families for their cooperation, Dr. Kevin Waters for providing paraffin blocks from one patient, and Dr. Lucy Gilbert for referring one patient. This study was supported by the Canadian Institute of Health Research [grant number MOP 86546]. R.S. is a recipient of a << Chercheur Boursier Senior >> from the << Fonds de Recherche en Sante du Quebec >>

References

 

DC FieldValueLanguage
dc.contributor.authorSlim, Ren_US
dc.contributor.authorAo, Aen_US
dc.contributor.authorSurti, Uen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorHoffner, Len_US
dc.contributor.authorArseneau, Jen_US
dc.contributor.authorCheung, Aen_US
dc.contributor.authorChebaro, Wen_US
dc.contributor.authorWischmeijer, Aen_US
dc.date.accessioned2012-05-29T06:14:17Z-
dc.date.available2012-05-29T06:14:17Z-
dc.date.issued2011en_US
dc.identifier.citationPlacenta, 2011, v. 32 n. 5, p. 409-412en_US
dc.identifier.issn0143-4004en_US
dc.identifier.urihttp://hdl.handle.net/10722/148638-
dc.description.abstractTo understand the mechanisms leading to hydatidiform mole formation in patients with NLRP7 mutations, we used a combination of various approaches to characterize five products of conception, from two patients, shown by flow cytometry to contain non-diploid cells. We demonstrate that four of these conceptions are triploid and two of them originated from fertilization with more than one sperm. We show that three of these triploid conceptions fulfill the histopathological criteria of partial hydatidiform mole and one fulfills the histopathological criteria of spontaneous abortion. Our data demonstrate that some oocytes from one patient with NLRP7 mutations are not able to prevent polyspermic fertilization and highlight the importance of using several approaches to characterize the genetic complexity of molar tissues and reproductive wastage. Altogether, our previous and current data show the association of NLRP7 mutations with several types of hydatidiform moles and with triploid spontaneous abortions. © 2011 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placentaen_US
dc.relation.ispartofPlacentaen_US
dc.subject.meshAdaptor Proteins, Signal Transducing - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilizationen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Geneticsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshTriploidyen_US
dc.titleRecurrent triploid and dispermic conceptions in patients with NLRP7 mutationsen_US
dc.typeArticleen_US
dc.identifier.emailCheung, A:anycheun@hkucc.hku.hken_US
dc.identifier.authorityCheung, A=rp00542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.placenta.2011.02.001en_US
dc.identifier.pmid21421271-
dc.identifier.scopuseid_2-s2.0-79955619462en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955619462&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue5en_US
dc.identifier.spage409en_US
dc.identifier.epage412en_US
dc.identifier.isiWOS:000291192000011-
dc.publisher.placeUnited Kingdomen_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats