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- Publisher Website: 10.1016/j.it.2009.09.004
- Scopus: eid_2-s2.0-70449854577
- PMID: 19864182
- WOS: WOS:000272643500004
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Article: Innate immune responses to influenza A H5N1: friend or foe?
Title | Innate immune responses to influenza A H5N1: friend or foe? | ||||||||||
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Authors | |||||||||||
Issue Date | 2009 | ||||||||||
Publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/it | ||||||||||
Citation | Trends In Immunology, 2009, v. 30 n. 12, p. 574-584 How to Cite? | ||||||||||
Abstract | Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease. © 2009 Elsevier Ltd. All rights reserved. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/148613 | ||||||||||
ISSN | 2023 Impact Factor: 13.1 2023 SCImago Journal Rankings: 4.163 | ||||||||||
ISI Accession Number ID |
Funding Information: We acknowledge research funding from the National Institutes of Health (NIAID Contract HHSN26620070005C), the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06), the Central Allocation Grant HKU1/05C and General Research Fund (HKU77370M) from the Research Grants Council of the Hong Kong Special Administrative Region. | ||||||||||
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Grants |
DC Field | Value | Language |
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dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Cheung, CY | en_US |
dc.contributor.author | Leung, CYH | en_US |
dc.contributor.author | Nicholls, JM | en_US |
dc.date.accessioned | 2012-05-29T06:14:07Z | - |
dc.date.available | 2012-05-29T06:14:07Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Trends In Immunology, 2009, v. 30 n. 12, p. 574-584 | en_US |
dc.identifier.issn | 1471-4906 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/148613 | - |
dc.description.abstract | Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease. © 2009 Elsevier Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/it | en_US |
dc.relation.ispartof | Trends in Immunology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunity, Innate | en_US |
dc.subject.mesh | Influenza A Virus, H1n1 Subtype - Immunology - Pathogenicity | en_US |
dc.subject.mesh | Influenza A Virus, H3n2 Subtype - Immunology - Pathogenicity | en_US |
dc.subject.mesh | Influenza A Virus, H5n1 Subtype - Immunology - Pathogenicity | en_US |
dc.subject.mesh | Influenza, Human - Epidemiology - Immunology - Pathology - Physiopathology | en_US |
dc.subject.mesh | Interferons - Metabolism | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Orthomyxoviridae Infections - Immunology - Physiopathology | en_US |
dc.subject.mesh | Respiratory Distress Syndrome, Adult - Immunology | en_US |
dc.subject.mesh | Tumor Necrosis Factor-Alpha - Metabolism | en_US |
dc.title | Innate immune responses to influenza A H5N1: friend or foe? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Peiris, JSM:malik@hkucc.hku.hk | en_US |
dc.identifier.email | Cheung, CY:chungey@hkucc.hku.hk | en_US |
dc.identifier.email | Leung, CYH:cyhleung@hkucc.hku.hk | en_US |
dc.identifier.email | Nicholls, JM:nicholls@pathology.hku.hk | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.identifier.authority | Cheung, CY=rp00404 | en_US |
dc.identifier.authority | Leung, CYH=rp00307 | en_US |
dc.identifier.authority | Nicholls, JM=rp00364 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.it.2009.09.004 | en_US |
dc.identifier.pmid | 19864182 | - |
dc.identifier.scopus | eid_2-s2.0-70449854577 | en_US |
dc.identifier.hkuros | 173495 | - |
dc.identifier.hkuros | 172050 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70449854577&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 574 | en_US |
dc.identifier.epage | 584 | en_US |
dc.identifier.eissn | 1471-4981 | - |
dc.identifier.isi | WOS:000272643500004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.relation.project | Control of Pandemic and Inter-pandemic Influenza | - |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | - |
dc.identifier.scopusauthorid | Cheung, CY=7202061836 | - |
dc.identifier.scopusauthorid | Leung, CYH=26531438300 | - |
dc.identifier.scopusauthorid | Nicholls, JM=7201463077 | - |
dc.identifier.citeulike | 6048417 | - |
dc.identifier.issnl | 1471-4906 | - |