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Article: cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis

TitlecDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis
Authors
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2004, v. 322 n. 3, p. 827-835 How to Cite?
AbstractChronic hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma. HBV encodes an oncogenic hepatitis B virus X protein (HBx), which can transactivate host cell transcriptional machinery and mediate cellular transformation. To disclose the early genetic response in HBx-mediated transformation process, we constructed a conditional HBx-expressing hepatocyte cell line, which allows us to compare the gene expression profiles under controllable HBx induction. A cDNA microarray containing more than 8700 mouse genes and ESTs was utilized to examine the gene expression profiles. We identified 260 candidate genes and 259 ESTs which have shown aberrant expression under HBx induction. Most of them are involved in signal transduction pathway, cell cycle control, metastasis, transcriptional regulation, immune response, and metabolism. These results provide additional insight into early cellular targets of HBx, which could give us a better understanding of the function of HBx and their progressive changes during HBx-mediated hepatocarcinogenesis. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148565
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, RKen_US
dc.contributor.authorLau, CYLen_US
dc.contributor.authorLee, SMYen_US
dc.contributor.authorTsui, SKWen_US
dc.contributor.authorFung, KPen_US
dc.contributor.authorWaye, MMYen_US
dc.date.accessioned2012-05-29T06:13:45Z-
dc.date.available2012-05-29T06:13:45Z-
dc.date.issued2004en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2004, v. 322 n. 3, p. 827-835en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148565-
dc.description.abstractChronic hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma. HBV encodes an oncogenic hepatitis B virus X protein (HBx), which can transactivate host cell transcriptional machinery and mediate cellular transformation. To disclose the early genetic response in HBx-mediated transformation process, we constructed a conditional HBx-expressing hepatocyte cell line, which allows us to compare the gene expression profiles under controllable HBx induction. A cDNA microarray containing more than 8700 mouse genes and ESTs was utilized to examine the gene expression profiles. We identified 260 candidate genes and 259 ESTs which have shown aberrant expression under HBx induction. Most of them are involved in signal transduction pathway, cell cycle control, metastasis, transcriptional regulation, immune response, and metabolism. These results provide additional insight into early cellular targets of HBx, which could give us a better understanding of the function of HBx and their progressive changes during HBx-mediated hepatocarcinogenesis. © 2004 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Virologyen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDna, Complementary - Geneticsen_US
dc.subject.meshGene Expression Profiling - Methodsen_US
dc.subject.meshHepatitis B Antigens - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Genetics - Virologyen_US
dc.subject.meshOligonucleotide Array Sequence Analysis - Methodsen_US
dc.subject.meshRecombinant Proteins - Metabolismen_US
dc.subject.meshTrans-Activators - Genetics - Physiologyen_US
dc.subject.meshTranscriptional Activationen_US
dc.subject.meshTransfectionen_US
dc.titlecDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesisen_US
dc.typeArticleen_US
dc.identifier.emailNg, RK:rayng@pathology.hku.hken_US
dc.identifier.authorityNg, RK=rp00273en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2004.07.188en_US
dc.identifier.pmid15336538-
dc.identifier.scopuseid_2-s2.0-4444222917en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444222917&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume322en_US
dc.identifier.issue3en_US
dc.identifier.spage827en_US
dc.identifier.epage835en_US
dc.identifier.isiWOS:000223710500018-
dc.publisher.placeUnited Statesen_US
dc.identifier.citeulike4085541-

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