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Article: Establishment and characterization of a human cholangiocarcinoma cell line.

TitleEstablishment and characterization of a human cholangiocarcinoma cell line.
Authors
Issue Date2007
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2007, v. 18 n. 5, p. 1195-1200 How to Cite?
AbstractCholangiocarcinoma (CC) is a rare malignant tumor arising from the biliary tract. The disease is notoriously difficult to diagnose and is usually fatal due to its late clinical presentation and the lack of effective non-surgical therapeutic strategies. To date, little is known about the cancer biology of the disease and the establishment and characterization of only a few CC cell lines have been reported. We report here the establishment of a new human cancer cell line, HKGZ-CC, from a moderate to poorly differentiated intrahepatic bile duct carcinoma from a Chinese patient. Morphological characteristics, growth kinetics, ability to grow on anchorage-independent soft agar, tumorigenicity in nude mice and cytogenetic features of the cell line were investigated. Chromosome banding karyotype and comparative genomic hybridization analyses revealed chromosomal changes in 1pter-p31, 1q31-qter, 3q, 8q21-qter, 9pter-9q34, 10, 13q21-qter and X. This newly established cell line should serve as a useful model for studying the molecular pathogenesis of CC.
Persistent Identifierhttp://hdl.handle.net/10722/148543
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Sen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorHuang, XHen_HK
dc.contributor.authorCao, LQen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2012-05-29T06:13:38Z-
dc.date.available2012-05-29T06:13:38Z-
dc.date.issued2007en_HK
dc.identifier.citationOncology Reports, 2007, v. 18 n. 5, p. 1195-1200en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148543-
dc.description.abstractCholangiocarcinoma (CC) is a rare malignant tumor arising from the biliary tract. The disease is notoriously difficult to diagnose and is usually fatal due to its late clinical presentation and the lack of effective non-surgical therapeutic strategies. To date, little is known about the cancer biology of the disease and the establishment and characterization of only a few CC cell lines have been reported. We report here the establishment of a new human cancer cell line, HKGZ-CC, from a moderate to poorly differentiated intrahepatic bile duct carcinoma from a Chinese patient. Morphological characteristics, growth kinetics, ability to grow on anchorage-independent soft agar, tumorigenicity in nude mice and cytogenetic features of the cell line were investigated. Chromosome banding karyotype and comparative genomic hybridization analyses revealed chromosomal changes in 1pter-p31, 1q31-qter, 3q, 8q21-qter, 9pter-9q34, 10, 13q21-qter and X. This newly established cell line should serve as a useful model for studying the molecular pathogenesis of CC.en_HK
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology reportsen_HK
dc.subject.meshAgeden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile Duct Neoplasms - Genetics - Pathologyen_US
dc.subject.meshBile Ducts, Intrahepatic - Pathologyen_US
dc.subject.meshCholangiocarcinoma - Genetics - Pathologyen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Bandingen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleEstablishment and characterization of a human cholangiocarcinoma cell line.en_HK
dc.typeArticleen_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17914572-
dc.identifier.scopuseid_2-s2.0-38449118638en_HK
dc.identifier.hkuros140330-
dc.identifier.volume18en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1195en_HK
dc.identifier.epage1200en_HK
dc.identifier.isiWOS:000250570400019-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridHuang, XH=8057162600en_HK
dc.identifier.scopusauthoridCao, LQ=15073862200en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridWang, Q=36485668200en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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