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Article: Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia

TitleMolecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia
Authors
KeywordsAcute Lymphoblastic Leukemia
Oncogene P190 Abl Protein
Philadelphia Chromosome Abl Proto
Issue Date1987
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-9069
Citation
Cytotechnology, 1987, v. 1 n. 1, p. 33-36 How to Cite?
AbstractIn classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, with increased tyrosine kinase activity. Such DNA rearrangement, with a p210 protein synthesis, is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL), but in apparently similar cases the bcr gene is not rearranged, and a novel p190 abl-related protein can be found; c-abl rearrangement has also been observed. It is thus established that correlations between cytogenetic and molecular events can be found in CGL and ALL, as in other haemopoietic malignancies: translocation and possible rearrangement of the c-abl oncogene seem of particular importance in this case. © 1988 Martinus Nijhoff Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/148514
ISSN
2015 Impact Factor: 1.864
2015 SCImago Journal Rankings: 0.525

 

DC FieldValueLanguage
dc.contributor.authorEridani, Sen_US
dc.contributor.authorWiedemann, LMen_US
dc.contributor.authorChan, LCen_US
dc.contributor.authorDalton, RGen_US
dc.contributor.authorKarhi, KKen_US
dc.date.accessioned2012-05-29T06:13:25Z-
dc.date.available2012-05-29T06:13:25Z-
dc.date.issued1987en_US
dc.identifier.citationCytotechnology, 1987, v. 1 n. 1, p. 33-36en_US
dc.identifier.issn0920-9069en_US
dc.identifier.urihttp://hdl.handle.net/10722/148514-
dc.description.abstractIn classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, with increased tyrosine kinase activity. Such DNA rearrangement, with a p210 protein synthesis, is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL), but in apparently similar cases the bcr gene is not rearranged, and a novel p190 abl-related protein can be found; c-abl rearrangement has also been observed. It is thus established that correlations between cytogenetic and molecular events can be found in CGL and ALL, as in other haemopoietic malignancies: translocation and possible rearrangement of the c-abl oncogene seem of particular importance in this case. © 1988 Martinus Nijhoff Publishers.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-9069en_US
dc.relation.ispartofCytotechnologyen_US
dc.subjectAcute Lymphoblastic Leukemiaen_US
dc.subjectOncogene P190 Abl Proteinen_US
dc.subjectPhiladelphia Chromosome Abl Protoen_US
dc.titleMolecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00351119en_US
dc.identifier.scopuseid_2-s2.0-34250087813en_US
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.spage33en_US
dc.identifier.epage36en_US
dc.publisher.placeNetherlandsen_US

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