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Article: Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

TitleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
Authors
KeywordsCatalase
Glutathione peroxidase
Lung cancer
Superoxide dismutase
Issue Date2007
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2007, v. 29 n. 2, p. 273-278 How to Cite?
Abstract
The present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.
Persistent Identifierhttp://hdl.handle.net/10722/148501
ISSN
2013 Impact Factor: 7.125
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorHo, JCen_HK
dc.contributor.authorChan-Yeung, Men_HK
dc.contributor.authorHo, SPen_HK
dc.contributor.authorMak, JCen_HK
dc.contributor.authorIp, MSen_HK
dc.contributor.authorOol, GCen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2012-05-29T06:13:20Z-
dc.date.available2012-05-29T06:13:20Z-
dc.date.issued2007en_HK
dc.identifier.citationEuropean Respiratory Journal, 2007, v. 29 n. 2, p. 273-278en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148501-
dc.description.abstractThe present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.en_HK
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectCatalaseen_HK
dc.subjectGlutathione peroxidaseen_HK
dc.subjectLung canceren_HK
dc.subjectSuperoxide dismutaseen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntioxidants - Analysis - Metabolismen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Enzymology - Etiology - Pathologyen_US
dc.subject.meshCatalase - Analysis - Metabolismen_US
dc.subject.meshCell Transformation, Neoplastic - Metabolismen_US
dc.subject.meshErythrocytes - Enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione Peroxidase - Analysis - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Neoplasms - Enzymology - Etiology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshOxidoreductases - Analysis - Metabolismen_US
dc.subject.meshSuperoxide Dismutase - Analysis - Metabolismen_US
dc.titleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailMak, JC:judymak@hku.hken_HK
dc.identifier.emailIp, MS:msmip@hku.hken_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityMak, JC=rp00352en_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1183/09031936.00000106en_HK
dc.identifier.pmid17005588en_HK
dc.identifier.scopuseid_2-s2.0-33846904094en_HK
dc.identifier.hkuros131106-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846904094&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage273en_HK
dc.identifier.epage278en_HK
dc.identifier.eissn1399-3003-
dc.identifier.isiWOS:000244283900010-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.scopusauthoridHo, SP=12794365900en_HK
dc.identifier.scopusauthoridMak, JC=7103323094en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK
dc.identifier.scopusauthoridOol, GC=15843979000en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.customcontrol.immutablejt 1305010-

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