Article: Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

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TitleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
AuthorsHo, JC1
Chan-Yeung, M
Ho, SP
Mak, JC1
Ip, MS1
Ool, GC
Wong, MP1
Tsang, KW
Lam, WK
KeywordsCatalase
Glutathione peroxidase
Lung cancer
Superoxide dismutase
Issue Date2007
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
CitationEuropean Respiratory Journal, 2007, v. 29 n. 2, p. 273-278 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00000106
AbstractThe present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.
ISSN0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
DOIhttp://dx.doi.org/10.1183/09031936.00000106
ISI Accession Number IDWOS:000244283900010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, JC
dc.contributor.authorChan-Yeung, M
dc.contributor.authorHo, SP
dc.contributor.authorMak, JC
dc.contributor.authorIp, MS
dc.contributor.authorOol, GC
dc.contributor.authorWong, MP
dc.contributor.authorTsang, KW
dc.contributor.authorLam, WK
dc.date.accessioned2012-05-29T06:13:20Z
dc.date.available2012-05-29T06:13:20Z
dc.date.issued2007
dc.description.abstractThe present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.
dc.description.natureLink_to_OA_fulltext
dc.identifier.citationEuropean Respiratory Journal, 2007, v. 29 n. 2, p. 273-278 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00000106
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.00000106
dc.identifier.epage278
dc.identifier.hkuros131106
dc.identifier.isiWOS:000244283900010
dc.identifier.issn0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
dc.identifier.issue2
dc.identifier.pmid17005588
dc.identifier.scopuseid_2-s2.0-33846904094
dc.identifier.spage273
dc.identifier.urihttp://hdl.handle.net/10722/148501
dc.identifier.volume29
dc.languageeng
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
dc.publisher.placeSwitzerland
dc.relation.ispartofEuropean Respiratory Journal
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntioxidants - Analysis - Metabolism
dc.subject.meshAsian Continental Ancestry Group
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Enzymology - Etiology - Pathology
dc.subject.meshCatalase - Analysis - Metabolism
dc.subject.meshCell Transformation, Neoplastic - Metabolism
dc.subject.meshErythrocytes - Enzymology
dc.subject.meshFemale
dc.subject.meshGlutathione Peroxidase - Analysis - Metabolism
dc.subject.meshHumans
dc.subject.meshLung Neoplasms - Enzymology - Etiology - Pathology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Staging
dc.subject.meshOxidoreductases - Analysis - Metabolism
dc.subject.meshSuperoxide Dismutase - Analysis - Metabolism
dc.subjectCatalase
dc.subjectGlutathione peroxidase
dc.subjectLung cancer
dc.subjectSuperoxide dismutase
dc.titleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong