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Article: Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
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TitleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
 
AuthorsHo, JC1
Chan-Yeung, M1
Ho, SP1
Mak, JC1
Ip, MS1
Ool, GC1
Wong, MP1
Tsang, KW1
Lam, WK1
 
KeywordsCatalase
Glutathione peroxidase
Lung cancer
Superoxide dismutase
 
Issue Date2007
 
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
CitationEuropean Respiratory Journal, 2007, v. 29 n. 2, p. 273-278 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00000106
 
AbstractThe present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.
 
ISSN0903-1936
2012 Impact Factor: 6.355
2012 SCImago Journal Rankings: 2.433
 
DOIhttp://dx.doi.org/10.1183/09031936.00000106
 
ISI Accession Number IDWOS:000244283900010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, JC
 
dc.contributor.authorChan-Yeung, M
 
dc.contributor.authorHo, SP
 
dc.contributor.authorMak, JC
 
dc.contributor.authorIp, MS
 
dc.contributor.authorOol, GC
 
dc.contributor.authorWong, MP
 
dc.contributor.authorTsang, KW
 
dc.contributor.authorLam, WK
 
dc.date.accessioned2012-05-29T06:13:20Z
 
dc.date.available2012-05-29T06:13:20Z
 
dc.date.issued2007
 
dc.description.abstractThe present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U·(ghaemoglobulin(Hb)-1), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU·(gHb)-1) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. Copyright © ERS Journals Ltd 2007.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationEuropean Respiratory Journal, 2007, v. 29 n. 2, p. 273-278 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00000106
 
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.00000106
 
dc.identifier.eissn1399-3003
 
dc.identifier.epage278
 
dc.identifier.hkuros131106
 
dc.identifier.isiWOS:000244283900010
 
dc.identifier.issn0903-1936
2012 Impact Factor: 6.355
2012 SCImago Journal Rankings: 2.433
 
dc.identifier.issue2
 
dc.identifier.pmid17005588
 
dc.identifier.scopuseid_2-s2.0-33846904094
 
dc.identifier.spage273
 
dc.identifier.urihttp://hdl.handle.net/10722/148501
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofEuropean Respiratory Journal
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAntioxidants - Analysis - Metabolism
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Enzymology - Etiology - Pathology
 
dc.subject.meshCatalase - Analysis - Metabolism
 
dc.subject.meshCell Transformation, Neoplastic - Metabolism
 
dc.subject.meshErythrocytes - Enzymology
 
dc.subject.meshFemale
 
dc.subject.meshGlutathione Peroxidase - Analysis - Metabolism
 
dc.subject.meshHumans
 
dc.subject.meshLung Neoplasms - Enzymology - Etiology - Pathology
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNeoplasm Staging
 
dc.subject.meshOxidoreductases - Analysis - Metabolism
 
dc.subject.meshSuperoxide Dismutase - Analysis - Metabolism
 
dc.subjectCatalase
 
dc.subjectGlutathione peroxidase
 
dc.subjectLung cancer
 
dc.subjectSuperoxide dismutase
 
dc.titleDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong