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Article: Lymphoepithelioma-like carcinoma of the lung

TitleLymphoepithelioma-like carcinoma of the lung
Authors
KeywordsEpstein-Barr virus
Lung
Lymphoepithelioma-like carcinoma
Prognosis
Treatment
Issue Date2006
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
Respirology, 2006, v. 11 n. 5, p. 539-545 How to Cite?
AbstractLymphoepithelioma-like carcinoma (LELC) of the lung was first reported in 1987. In the past two decades, there have been just more than 150 cases reported in the literature. This uncommon but distinct form of non-small cell lung carcinoma has a predilection for young non-smoking Asians, without gender distinction. Histologically, it is indistinguishable from undifferentiated nasopharyngeal carcinoma. The carcinogenic role of latent Epstein-Barr virus infection in causing LELC of the lung has been evident almost exclusively in Asians compared with Caucasians. Among the reported cases, more than half were in early resectable stages (I or II) and there was a tendency for peribronchovascular spread with vascular encasement in advanced diseases. In order to establish the diagnosis of LELC of the lung, both nasopharyngeal carcinoma and lymphoma have to be excluded by endoscopic biopsy (with or without magnetic resonance imaging of the nasopharynx) and immunohistochemical staining of the biopsy samples. The mainstay of treatment for early-stage disease is curative surgical resection, whereas multimodality treatment (surgery, chemotherapy, radiotherapy) has been adopted in advanced or metastatic diseases. The overall survival is more favourable in LELC of the lung compared with non-LELC type of non-small cell lung carcinoma. Future collaborative studies especially on optimizing treatment for this uncommon malignancy are clearly warranted. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/148473
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JCen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2012-05-29T06:13:10Z-
dc.date.available2012-05-29T06:13:10Z-
dc.date.issued2006en_HK
dc.identifier.citationRespirology, 2006, v. 11 n. 5, p. 539-545en_HK
dc.identifier.issn1323-7799en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148473-
dc.description.abstractLymphoepithelioma-like carcinoma (LELC) of the lung was first reported in 1987. In the past two decades, there have been just more than 150 cases reported in the literature. This uncommon but distinct form of non-small cell lung carcinoma has a predilection for young non-smoking Asians, without gender distinction. Histologically, it is indistinguishable from undifferentiated nasopharyngeal carcinoma. The carcinogenic role of latent Epstein-Barr virus infection in causing LELC of the lung has been evident almost exclusively in Asians compared with Caucasians. Among the reported cases, more than half were in early resectable stages (I or II) and there was a tendency for peribronchovascular spread with vascular encasement in advanced diseases. In order to establish the diagnosis of LELC of the lung, both nasopharyngeal carcinoma and lymphoma have to be excluded by endoscopic biopsy (with or without magnetic resonance imaging of the nasopharynx) and immunohistochemical staining of the biopsy samples. The mainstay of treatment for early-stage disease is curative surgical resection, whereas multimodality treatment (surgery, chemotherapy, radiotherapy) has been adopted in advanced or metastatic diseases. The overall survival is more favourable in LELC of the lung compared with non-LELC type of non-small cell lung carcinoma. Future collaborative studies especially on optimizing treatment for this uncommon malignancy are clearly warranted. © 2006 The Authors.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RESen_HK
dc.relation.ispartofRespirologyen_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectLungen_HK
dc.subjectLymphoepithelioma-like carcinomaen_HK
dc.subjectPrognosisen_HK
dc.subjectTreatmenten_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Diagnosis - Epidemiology - Therapyen_US
dc.subject.meshFar East - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Pathologyen_US
dc.subject.meshLung Neoplasms - Diagnosis - Epidemiology - Therapyen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPrognosisen_US
dc.titleLymphoepithelioma-like carcinoma of the lungen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1440-1843.2006.00910.xen_HK
dc.identifier.pmid16916325-
dc.identifier.scopuseid_2-s2.0-33746916009en_HK
dc.identifier.hkuros117979-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746916009&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue5en_HK
dc.identifier.spage539en_HK
dc.identifier.epage545en_HK
dc.identifier.isiWOS:000240499200004-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.citeulike785800-

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