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Article: Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug

TitleKetoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug
Authors
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 12, p. 1375-1377 How to Cite?
AbstractKetoconazole Induced Torsades de Pointes Ketoconazole is not known to be proarrhythmic without concomitant use of QT interval-prolonging drugs. We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infection. Her QT interval returned to normal upon withdrawal of ketoconazole. Genetic study did not find any mutation in her genes that encode cardiac IKr channel proteins. We postulate that by virtue of its direct blocking action on IKr, ketoconazole alone may prolong QT interval and induce TdP. This calls for attention when ketoconazole is administered to patients with risk factors for acquired long QT syndrome.
Persistent Identifierhttp://hdl.handle.net/10722/148455
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, NSen_US
dc.contributor.authorLo, YKen_US
dc.contributor.authorTsui, PTen_US
dc.contributor.authorLam, CWen_US
dc.date.accessioned2012-05-29T06:13:05Z-
dc.date.available2012-05-29T06:13:05Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 12, p. 1375-1377en_US
dc.identifier.issn1045-3873en_US
dc.identifier.urihttp://hdl.handle.net/10722/148455-
dc.description.abstractKetoconazole Induced Torsades de Pointes Ketoconazole is not known to be proarrhythmic without concomitant use of QT interval-prolonging drugs. We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infection. Her QT interval returned to normal upon withdrawal of ketoconazole. Genetic study did not find any mutation in her genes that encode cardiac IKr channel proteins. We postulate that by virtue of its direct blocking action on IKr, ketoconazole alone may prolong QT interval and induce TdP. This calls for attention when ketoconazole is administered to patients with risk factors for acquired long QT syndrome.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_US
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_US
dc.subject.meshAntifungal Agents - Adverse Effectsen_US
dc.subject.meshCoronary Artery Disease - Genetics - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKetoconazole - Adverse Effectsen_US
dc.subject.meshLong Qt Syndrome - Chemically Induceden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTorsades De Pointes - Chemically Induced - Geneticsen_US
dc.titleKetoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drugen_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1540-8167.2005.00299.xen_US
dc.identifier.pmid16403073-
dc.identifier.scopuseid_2-s2.0-33644869735en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644869735&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue12en_US
dc.identifier.spage1375en_US
dc.identifier.epage1377en_US
dc.identifier.isiWOS:000233807600021-
dc.publisher.placeUnited Statesen_US

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