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- Publisher Website: 10.4161/cc.4.6.1743
- Scopus: eid_2-s2.0-25144446721
- PMID: 15970697
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Article: Maintenance of epigenetic memory in cloned embryos
Title | Maintenance of epigenetic memory in cloned embryos |
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Authors | |
Keywords | Cloning Differentiation DNA methylation Epigenetic memory Gene expression Histone Nuclear transplantation |
Issue Date | 2005 |
Publisher | Landes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cc |
Citation | Cell Cycle, 2005, v. 4 n. 6, p. 760-763 How to Cite? |
Abstract | Different cell types have characteristic patterns of gene expression. Once a cell has differentiated, its daughter cells nearly always differentiate in the same way. The maintenance of cell lineage involves either instructions from a cell's surroundings or the inheritance of memory from a parent cell. In normal development, the differentiation state of a cell is remarkably stable and irreversible. However the transplantation of a somatic cell nucleus to an enucleated egg often leads to a complete reprogramming of gene expression. We summarize here the results of some Amphibian nuclear transfer experiments that reveal a memory of gene expression. This and some other experiments exemplify epigenetic memory that persists through many cell divisions. In the case of nuclear transfer experiments, the actively transcribed state of a gene can be propagated through many cell divisions in the absence of the stimulus that first induced the activity of this gene. We discuss the possible basis of these two examples of persistent epigenetic memory, namely changes at DNA methylation and histone modifications. ©2005 Landes Bioscience. |
Persistent Identifier | http://hdl.handle.net/10722/148428 |
ISSN | 2021 Impact Factor: 5.173 2020 SCImago Journal Rankings: 1.320 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, RK | en_US |
dc.contributor.author | Gurdon, JB | en_US |
dc.date.accessioned | 2012-05-29T06:12:55Z | - |
dc.date.available | 2012-05-29T06:12:55Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Cell Cycle, 2005, v. 4 n. 6, p. 760-763 | en_US |
dc.identifier.issn | 1538-4101 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/148428 | - |
dc.description.abstract | Different cell types have characteristic patterns of gene expression. Once a cell has differentiated, its daughter cells nearly always differentiate in the same way. The maintenance of cell lineage involves either instructions from a cell's surroundings or the inheritance of memory from a parent cell. In normal development, the differentiation state of a cell is remarkably stable and irreversible. However the transplantation of a somatic cell nucleus to an enucleated egg often leads to a complete reprogramming of gene expression. We summarize here the results of some Amphibian nuclear transfer experiments that reveal a memory of gene expression. This and some other experiments exemplify epigenetic memory that persists through many cell divisions. In the case of nuclear transfer experiments, the actively transcribed state of a gene can be propagated through many cell divisions in the absence of the stimulus that first induced the activity of this gene. We discuss the possible basis of these two examples of persistent epigenetic memory, namely changes at DNA methylation and histone modifications. ©2005 Landes Bioscience. | en_US |
dc.language | eng | en_US |
dc.publisher | Landes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cc | en_US |
dc.relation.ispartof | Cell Cycle | en_US |
dc.subject | Cloning | - |
dc.subject | Differentiation | - |
dc.subject | DNA methylation | - |
dc.subject | Epigenetic memory | - |
dc.subject | Gene expression | - |
dc.subject | Histone | - |
dc.subject | Nuclear transplantation | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cloning, Organism | en_US |
dc.subject.mesh | Embryo, Mammalian - Metabolism | en_US |
dc.subject.mesh | Embryo, Nonmammalian | en_US |
dc.subject.mesh | Epigenesis, Genetic - Genetics | en_US |
dc.subject.mesh | Models, Biological | en_US |
dc.title | Maintenance of epigenetic memory in cloned embryos | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ng, RK:rayng@pathology.hku.hk | en_US |
dc.identifier.authority | Ng, RK=rp00273 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4161/cc.4.6.1743 | - |
dc.identifier.pmid | 15970697 | - |
dc.identifier.scopus | eid_2-s2.0-25144446721 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-25144446721&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 760 | en_US |
dc.identifier.epage | 763 | en_US |
dc.identifier.isi | WOS:000229658100009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 1551-4005 | - |