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Article: Maintenance of epigenetic memory in cloned embryos

TitleMaintenance of epigenetic memory in cloned embryos
Authors
Issue Date2005
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cc
Citation
Cell Cycle, 2005, v. 4 n. 6, p. 760-763 How to Cite?
AbstractDifferent cell types have characteristic patterns of gene expression. Once a cell has differentiated, its daughter cells nearly always differentiate in the same way. The maintenance of cell lineage involves either instructions from a cell's surroundings or the inheritance of memory from a parent cell. In normal development, the differentiation state of a cell is remarkably stable and irreversible. However the transplantation of a somatic cell nucleus to an enucleated egg often leads to a complete reprogramming of gene expression. We summarize here the results of some Amphibian nuclear transfer experiments that reveal a memory of gene expression. This and some other experiments exemplify epigenetic memory that persists through many cell divisions. In the case of nuclear transfer experiments, the actively transcribed state of a gene can be propagated through many cell divisions in the absence of the stimulus that first induced the activity of this gene. We discuss the possible basis of these two examples of persistent epigenetic memory, namely changes at DNA methylation and histone modifications. ©2005 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/148428
ISSN
2015 Impact Factor: 3.952
2015 SCImago Journal Rankings: 2.244
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, RKen_US
dc.contributor.authorGurdon, JBen_US
dc.date.accessioned2012-05-29T06:12:55Z-
dc.date.available2012-05-29T06:12:55Z-
dc.date.issued2005en_US
dc.identifier.citationCell Cycle, 2005, v. 4 n. 6, p. 760-763en_US
dc.identifier.issn1538-4101en_US
dc.identifier.urihttp://hdl.handle.net/10722/148428-
dc.description.abstractDifferent cell types have characteristic patterns of gene expression. Once a cell has differentiated, its daughter cells nearly always differentiate in the same way. The maintenance of cell lineage involves either instructions from a cell's surroundings or the inheritance of memory from a parent cell. In normal development, the differentiation state of a cell is remarkably stable and irreversible. However the transplantation of a somatic cell nucleus to an enucleated egg often leads to a complete reprogramming of gene expression. We summarize here the results of some Amphibian nuclear transfer experiments that reveal a memory of gene expression. This and some other experiments exemplify epigenetic memory that persists through many cell divisions. In the case of nuclear transfer experiments, the actively transcribed state of a gene can be propagated through many cell divisions in the absence of the stimulus that first induced the activity of this gene. We discuss the possible basis of these two examples of persistent epigenetic memory, namely changes at DNA methylation and histone modifications. ©2005 Landes Bioscience.en_US
dc.languageengen_US
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/ccen_US
dc.relation.ispartofCell Cycleen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCloning, Organismen_US
dc.subject.meshEmbryo, Mammalian - Metabolismen_US
dc.subject.meshEmbryo, Nonmammalianen_US
dc.subject.meshEpigenesis, Genetic - Geneticsen_US
dc.subject.meshModels, Biologicalen_US
dc.titleMaintenance of epigenetic memory in cloned embryosen_US
dc.typeArticleen_US
dc.identifier.emailNg, RK:rayng@pathology.hku.hken_US
dc.identifier.authorityNg, RK=rp00273en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15970697-
dc.identifier.scopuseid_2-s2.0-25144446721en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25144446721&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue6en_US
dc.identifier.spage760en_US
dc.identifier.epage763en_US
dc.identifier.isiWOS:000229658100009-
dc.publisher.placeUnited Statesen_US

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