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Article: Frequent allelic loss of 21q11.1~q21.1 region in advanced stage oral squamous cell carcinoma

TitleFrequent allelic loss of 21q11.1~q21.1 region in advanced stage oral squamous cell carcinoma
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2005, v. 159 n. 1, p. 37-43 How to Cite?
AbstractA fine mapping of loss of heterozygosity (LOH) was performed in oral squamous cell carcinoma (OSCC), using 12 markers on 21q11.1∼q21.1. We studied 43 resected primary invasive tumors and their paired normal tissues, concurrent dysplasia or carcinoma in situ in separate areas from 8 of the specimens, and 6 local recurrent carcinomas. LOH status was compared between lesions of different phases of progression within the same patient. A high frequency of LOH was observed for D21S1410, D21S120, and D21S1433 (60% each) in the primary lesions, constituting two interstitial deleted regions encompassing eight known genes. Cases showing LOH of D21S120 were significantly associated with advanced clinical stages (III and IV; P = 0.02). Consistent allelic loss was observed in 64.2% of the informative cases between the precursor lesions and their corresponding invasive tumors, and in 59.5% of those between the primary lesions and their recurrent counterparts. Fewer than half of the different lesions within a given patient showed discordant allelic loss for tested markers. Our results suggest that 21q11.1∼q21.1 harbors tumor suppressor genes in OSCC. Genetic divergence may develop during tumor clone evolution. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148405
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Len_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorCheung, LKen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorBaum, Len_HK
dc.contributor.authorSamman, Nen_HK
dc.date.accessioned2012-05-29T06:12:46Z-
dc.date.available2012-05-29T06:12:46Z-
dc.date.issued2005en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2005, v. 159 n. 1, p. 37-43en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148405-
dc.description.abstractA fine mapping of loss of heterozygosity (LOH) was performed in oral squamous cell carcinoma (OSCC), using 12 markers on 21q11.1∼q21.1. We studied 43 resected primary invasive tumors and their paired normal tissues, concurrent dysplasia or carcinoma in situ in separate areas from 8 of the specimens, and 6 local recurrent carcinomas. LOH status was compared between lesions of different phases of progression within the same patient. A high frequency of LOH was observed for D21S1410, D21S120, and D21S1433 (60% each) in the primary lesions, constituting two interstitial deleted regions encompassing eight known genes. Cases showing LOH of D21S120 were significantly associated with advanced clinical stages (III and IV; P = 0.02). Consistent allelic loss was observed in 64.2% of the informative cases between the precursor lesions and their corresponding invasive tumors, and in 59.5% of those between the primary lesions and their recurrent counterparts. Fewer than half of the different lesions within a given patient showed discordant allelic loss for tested markers. Our results suggest that 21q11.1∼q21.1 harbors tumor suppressor genes in OSCC. Genetic divergence may develop during tumor clone evolution. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.subject.meshCarcinoma In Situ - Geneticsen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 21 - Geneticsen_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeatsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth Neoplasms - Geneticsen_US
dc.subject.meshNeoplasm Invasiveness - Geneticsen_US
dc.subject.meshNeoplasm Recurrence, Local - Geneticsen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleFrequent allelic loss of 21q11.1~q21.1 region in advanced stage oral squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.emailSamman, N:nsamman@hkucc.hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.identifier.authoritySamman, N=rp00021en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cancergencyto.2004.09.011en_HK
dc.identifier.pmid15860355-
dc.identifier.scopuseid_2-s2.0-18144399976en_HK
dc.identifier.hkuros98078-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18144399976&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume159en_HK
dc.identifier.issue1en_HK
dc.identifier.spage37en_HK
dc.identifier.epage43en_HK
dc.identifier.isiWOS:000229099100006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, L=7409436858en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridBaum, L=7103310839en_HK
dc.identifier.scopusauthoridSamman, N=7006413627en_HK

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