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Article: Cytomegalovirus infection associated with clonal proliferation of T-cell large granular lymphocytes: Causal or casual?

TitleCytomegalovirus infection associated with clonal proliferation of T-cell large granular lymphocytes: Causal or casual?
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2003, v. 142 n. 1, p. 77-79 How to Cite?
AbstractClonal proliferation of T-cell large granular lymphocytes (LGL) is an indolent disorder characterized by splenomegaly, lymphocytosis and frequent manifestations of immune disturbances. The LGL are CD3+ CD4- CD8+ CD56-. The clonality of the tumor cell population is often only demonstrable by T-cell receptor (TCR) gene rearrangement study because chromosomal abnormality is distinctly rare. We describe a case of T-cell LGL leukemia that presented initially as cytomegalovirus infection. The leukemic LGL are shown to be clonal by both TCR gene rearrangement and chromosomal studies. They persist after subsidence of the cytomegalovirus infection. © 2003 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148364
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorYip, SFen_US
dc.contributor.authorSo, CCen_US
dc.contributor.authorLau, GTCen_US
dc.contributor.authorYeung, YMen_US
dc.date.accessioned2012-05-29T06:12:29Z-
dc.date.available2012-05-29T06:12:29Z-
dc.date.issued2003en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2003, v. 142 n. 1, p. 77-79en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/148364-
dc.description.abstractClonal proliferation of T-cell large granular lymphocytes (LGL) is an indolent disorder characterized by splenomegaly, lymphocytosis and frequent manifestations of immune disturbances. The LGL are CD3+ CD4- CD8+ CD56-. The clonality of the tumor cell population is often only demonstrable by T-cell receptor (TCR) gene rearrangement study because chromosomal abnormality is distinctly rare. We describe a case of T-cell LGL leukemia that presented initially as cytomegalovirus infection. The leukemic LGL are shown to be clonal by both TCR gene rearrangement and chromosomal studies. They persist after subsidence of the cytomegalovirus infection. © 2003 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Cd3 - Metabolismen_US
dc.subject.meshAntigens, Cd56 - Metabolismen_US
dc.subject.meshAntigens, Cd8 - Metabolismen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Physiologyen_US
dc.subject.meshClone Cells - Immunology - Pathologyen_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshCytomegalovirus Infections - Complications - Pathologyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGene Rearrangement, T-Lymphocyteen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Lymphoid - Diagnosis - Etiology - Pathologyen_US
dc.subject.meshLymphocytosis - Diagnosis - Etiology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshReceptors, Antigen, T-Cell, Gamma-Delta - Geneticsen_US
dc.subject.meshT-Lymphocytes - Immunology - Pathologyen_US
dc.titleCytomegalovirus infection associated with clonal proliferation of T-cell large granular lymphocytes: Causal or casual?en_US
dc.typeArticleen_US
dc.identifier.emailSo, CC:scc@pathology.hku.hken_US
dc.identifier.authoritySo, CC=rp00391en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(02)00739-2en_US
dc.identifier.pmid12660039-
dc.identifier.scopuseid_2-s2.0-0344837401en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344837401&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume142en_US
dc.identifier.issue1en_US
dc.identifier.spage77en_US
dc.identifier.epage79en_US
dc.identifier.isiWOS:000181790300015-
dc.publisher.placeUnited Statesen_US

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