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Article: Genetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kong

TitleGenetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kong
Authors
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 2003, v. 71 n. 3, p. 429-433 How to Cite?
AbstractGlycoprotein B (gB) and glycoprotein H (gH) of human herpesvirus 7 (HHV-7) are believed to play an important role in virus entry and as targets for host immune response. This study examined the genetic diversity of these glycoproteins among 90 HHV-7 isolates collected from different individuals in Hong Kong. Overall, both the gB and gH genes were found to be highly conserved. Nucleotide polymorphism was detected only at four positions of the gB-encoding region, and all of these were synonymous substitutions. Most (97.8%) Hong Kong isolates were of gB allele group C. Two isolates collected from a Pakistani family showed a novel sequence pattern that did not match known gB allele groups. This sequence pattern was detected consistently from serial samples collected from the same individual, indicating a stable genetic entity. The gH-encoding region exhibited nucleotide polymorphism at six positions. Three of these were nonsynonymous substitutions (codon 271 Lys → Gln, codon 308 Gly → Glu, codon 397 Asn → ]Tyr). Most (84.4%) Hong Kong isolates were of the gH allele group B, and all others were of the gH allele group C. These data indicate the possibility of using gB or gH alleles as markers for studying world-wide population movements and genetics. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148357
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, PKSen_US
dc.contributor.authorLi, CKen_US
dc.contributor.authorChik, KWen_US
dc.contributor.authorShing, MMKen_US
dc.contributor.authorLee, Ven_US
dc.contributor.authorNg, KCen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorCheung, JLKen_US
dc.contributor.authorCheng, AFen_US
dc.date.accessioned2012-05-29T06:12:27Z-
dc.date.available2012-05-29T06:12:27Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Medical Virology, 2003, v. 71 n. 3, p. 429-433en_US
dc.identifier.issn0146-6615en_US
dc.identifier.urihttp://hdl.handle.net/10722/148357-
dc.description.abstractGlycoprotein B (gB) and glycoprotein H (gH) of human herpesvirus 7 (HHV-7) are believed to play an important role in virus entry and as targets for host immune response. This study examined the genetic diversity of these glycoproteins among 90 HHV-7 isolates collected from different individuals in Hong Kong. Overall, both the gB and gH genes were found to be highly conserved. Nucleotide polymorphism was detected only at four positions of the gB-encoding region, and all of these were synonymous substitutions. Most (97.8%) Hong Kong isolates were of gB allele group C. Two isolates collected from a Pakistani family showed a novel sequence pattern that did not match known gB allele groups. This sequence pattern was detected consistently from serial samples collected from the same individual, indicating a stable genetic entity. The gH-encoding region exhibited nucleotide polymorphism at six positions. Three of these were nonsynonymous substitutions (codon 271 Lys → Gln, codon 308 Gly → Glu, codon 397 Asn → ]Tyr). Most (84.4%) Hong Kong isolates were of the gH allele group B, and all others were of the gH allele group C. These data indicate the possibility of using gB or gH alleles as markers for studying world-wide population movements and genetics. © 2003 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCodonen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHerpesvirus 7, Human - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshRoseolovirus Infections - Epidemiology - Virologyen_US
dc.subject.meshViral Envelope Proteins - Geneticsen_US
dc.titleGenetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmv.10496en_US
dc.identifier.pmid12966550-
dc.identifier.scopuseid_2-s2.0-0141869904en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141869904&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume71en_US
dc.identifier.issue3en_US
dc.identifier.spage429en_US
dc.identifier.epage433en_US
dc.identifier.isiWOS:000185567600016-
dc.publisher.placeUnited Statesen_US

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