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Article: Plasmablastic transformation of multiple myeloma

TitlePlasmablastic transformation of multiple myeloma
Authors
Issue Date2003
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2003, v. 34 n. 7, p. 710-714 How to Cite?
AbstractWe describe morphological, immunophenotypic, and cytogenetic characterization of a case of multiple myeloma (MM) that showed plasmablastic transformation at the terminal phase with a picture resembling acute leukemia. The plasmablasts expressed monotypic cytoplasmic immunoglobulin together with myeloid and megakaryocytic markers at disease transformation. Conventional cytogenetic study of bone marrow cells showed coexistence of hypodiploid and hyperdiploid cells, with the former being the predominant clone as evidenced by an interphase fluorescence in situ hybridization study. The clinical course in our case shows that plasmablastic transformation should be considered in the differential diagnoses of disease progression in MM. Whether de novo plasmablastic myeloma and plasmablastic transformation can be distinguished as a progression from underlying MM merits further investigation, especially in terms of biologic features and relevance to prognosis. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148334
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, CKen_US
dc.contributor.authorMa, ESKen_US
dc.contributor.authorShek, TWHen_US
dc.contributor.authorLam, CCKen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:12:17Z-
dc.date.available2012-05-29T06:12:17Z-
dc.date.issued2003en_US
dc.identifier.citationHuman Pathology, 2003, v. 34 n. 7, p. 710-714en_US
dc.identifier.issn0046-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/148334-
dc.description.abstractWe describe morphological, immunophenotypic, and cytogenetic characterization of a case of multiple myeloma (MM) that showed plasmablastic transformation at the terminal phase with a picture resembling acute leukemia. The plasmablasts expressed monotypic cytoplasmic immunoglobulin together with myeloid and megakaryocytic markers at disease transformation. Conventional cytogenetic study of bone marrow cells showed coexistence of hypodiploid and hyperdiploid cells, with the former being the predominant clone as evidenced by an interphase fluorescence in situ hybridization study. The clinical course in our case shows that plasmablastic transformation should be considered in the differential diagnoses of disease progression in MM. Whether de novo plasmablastic myeloma and plasmablastic transformation can be distinguished as a progression from underlying MM merits further investigation, especially in terms of biologic features and relevance to prognosis. © 2003 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_US
dc.relation.ispartofHuman Pathologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAneuploidyen_US
dc.subject.meshBone Marrow - Pathologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshInterphaseen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshMaleen_US
dc.subject.meshMultiple Myeloma - Genetics - Immunology - Pathologyen_US
dc.subject.meshOrganelles - Ultrastructureen_US
dc.subject.meshPlasma Cells - Immunology - Pathologyen_US
dc.titlePlasmablastic transformation of multiple myelomaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0046-8177(03)00181-3en_US
dc.identifier.pmid12874768-
dc.identifier.scopuseid_2-s2.0-0037707202en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037707202&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue7en_US
dc.identifier.spage710en_US
dc.identifier.epage714en_US
dc.identifier.isiWOS:000184249100012-
dc.publisher.placeUnited Statesen_US

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