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Article: Aberrant promoter methylation in gastric lymphomas

TitleAberrant promoter methylation in gastric lymphomas
Authors
Issue Date2003
Citation
Haematologica, 2003, v. 88 n. 2, p. 231-232 How to Cite?
AbstractAberrant gene promoter methylation of p15, p16, p73, VHL, caspase 8, and hMLH1 was investigated in gastric mucosa-associated lymphoid tissue (MALT) and diffuse large B cell (DLBC) lymphomas, with nodal marginal zone B-cell (MZBC, counterpart of MALT) and DLBC lymphomas studied in comparison. MALT/MZBC lymphomas shared similar methylation patterns, with more frequent p 15 and p 16 methylation than gastric/nodal DLBC lymphomas, which themselves had comparable methylation patterns. Therefore, gastric MALT appeared biologically similar to nodal MZCB lymphoma, but distinct from gastric DLBC lymphoma. Gastric DLBC is more prevalent than MALT lymphoma in our population. Our results suggested that this might not represent a higher transformation rate of the latter to the former.
Persistent Identifierhttp://hdl.handle.net/10722/148333
ISSN
2015 Impact Factor: 6.671
2015 SCImago Journal Rankings: 3.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, MKLen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-05-29T06:12:17Z-
dc.date.available2012-05-29T06:12:17Z-
dc.date.issued2003en_HK
dc.identifier.citationHaematologica, 2003, v. 88 n. 2, p. 231-232en_HK
dc.identifier.issn0390-6078en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148333-
dc.description.abstractAberrant gene promoter methylation of p15, p16, p73, VHL, caspase 8, and hMLH1 was investigated in gastric mucosa-associated lymphoid tissue (MALT) and diffuse large B cell (DLBC) lymphomas, with nodal marginal zone B-cell (MZBC, counterpart of MALT) and DLBC lymphomas studied in comparison. MALT/MZBC lymphomas shared similar methylation patterns, with more frequent p 15 and p 16 methylation than gastric/nodal DLBC lymphomas, which themselves had comparable methylation patterns. Therefore, gastric MALT appeared biologically similar to nodal MZCB lymphoma, but distinct from gastric DLBC lymphoma. Gastric DLBC is more prevalent than MALT lymphoma in our population. Our results suggested that this might not represent a higher transformation rate of the latter to the former.en_HK
dc.languageengen_US
dc.relation.ispartofHaematologicaen_HK
dc.subject.meshDna Methylationen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoma - Geneticsen_US
dc.subject.meshLymphoma, B-Cell, Marginal Zone - Geneticsen_US
dc.subject.meshLymphoma, Large B-Cell, Diffuse - Geneticsen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshStomach Neoplasms - Geneticsen_US
dc.titleAberrant promoter methylation in gastric lymphomasen_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid12604419en_HK
dc.identifier.scopuseid_2-s2.0-0037608690en_HK
dc.identifier.hkuros77692-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037608690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue2en_HK
dc.identifier.spage231en_HK
dc.identifier.epage232en_HK
dc.identifier.isiWOS:000181037700022-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridFung, MKL=7101955331en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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