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Article: Chromosomal distribution of the human cardiovascular transcriptome

TitleChromosomal distribution of the human cardiovascular transcriptome
Authors
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 2003, v. 81 n. 5, p. 519-524 How to Cite?
AbstractOn the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome. © 2003 Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148328
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarrans, JDen_US
dc.contributor.authorIp, Jen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorHwang, ILen_US
dc.contributor.authorDzau, VJen_US
dc.contributor.authorLiew, CCen_US
dc.date.accessioned2012-05-29T06:12:15Z-
dc.date.available2012-05-29T06:12:15Z-
dc.date.issued2003en_US
dc.identifier.citationGenomics, 2003, v. 81 n. 5, p. 519-524en_US
dc.identifier.issn0888-7543en_US
dc.identifier.urihttp://hdl.handle.net/10722/148328-
dc.description.abstractOn the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome. © 2003 Elsevier Science (USA). All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_US
dc.relation.ispartofGenomicsen_US
dc.subject.meshCardiovascular System - Metabolismen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDna, Complementaryen_US
dc.subject.meshDatabases, Nucleic Aciden_US
dc.subject.meshExpressed Sequence Tagsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshHumansen_US
dc.titleChromosomal distribution of the human cardiovascular transcriptomeen_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0888-7543(03)00008-9en_US
dc.identifier.pmid12706110-
dc.identifier.scopuseid_2-s2.0-0037405387en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037405387&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue5en_US
dc.identifier.spage519en_US
dc.identifier.epage524en_US
dc.identifier.isiWOS:000182464800008-
dc.publisher.placeUnited Statesen_US

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