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Article: The spectrum of acute lymphoblastic leukemia with mature B-cell phenotype

TitleThe spectrum of acute lymphoblastic leukemia with mature B-cell phenotype
Authors
Chan, NPHMa, ESKWan, TSKChan, LC
KeywordsAcute lymphoblastic leukemia
Cytogenetics
Immunophenotype
Mature B-cell
Morphology
Issue Date2003
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 2003, v. 27 n. 3, p. 231-234 How to Cite?
DOI: http://dx.doi.org/10.1016/S0145-2126(02)00129-7
AbstractWe showed heterogeneous disease spectrum among 15 acute lymphoblastic leukemia (ALL) cases with mature B-cell phenotype diagnosed over the past 7 years at our institution. Besides those with typical L3 morphology and 8q24 (c-myc) translocation (n=6), there were cases showing L1 or L2 morphology without 8q24 translocation (n=6), unusually large L3 blasts in hyperdiploid clone (n=2) and blastoid variant of mantle cell lymphoma (n=1). The expression of CD5 and cyclin D1 may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148324
ISSN
0145-2126
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.694
ISI Accession Number ID
WOS:000181019600006
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, NPHen_US
dc.contributor.authorMa, ESKen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:12:13Z-
dc.date.available2012-05-29T06:12:13Z-
dc.date.issued2003en_US
dc.identifier.citationLeukemia Research, 2003, v. 27 n. 3, p. 231-234en_US
dc.identifier.issn0145-2126en_US
dc.identifier.urihttp://hdl.handle.net/10722/148324-
dc.description.abstractWe showed heterogeneous disease spectrum among 15 acute lymphoblastic leukemia (ALL) cases with mature B-cell phenotype diagnosed over the past 7 years at our institution. Besides those with typical L3 morphology and 8q24 (c-myc) translocation (n=6), there were cases showing L1 or L2 morphology without 8q24 translocation (n=6), unusually large L3 blasts in hyperdiploid clone (n=2) and blastoid variant of mantle cell lymphoma (n=1). The expression of CD5 and cyclin D1 may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management. © 2002 Elsevier Science Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_US
dc.relation.ispartofLeukemia Researchen_US
dc.subjectAcute lymphoblastic leukemia-
dc.subjectCytogenetics-
dc.subjectImmunophenotype-
dc.subjectMature B-cell-
dc.subjectMorphology-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntigens, Cd5 - Analysisen_US
dc.subject.meshBone Marrow Examinationen_US
dc.subject.meshBurkitt Lymphoma - Classification - Genetics - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChromosomes, Human, Pair 14en_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshCyclin D1 - Analysisen_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshLymphoma, Mantle-Cell - Diagnosis - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Classification - Genetics - Pathologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleThe spectrum of acute lymphoblastic leukemia with mature B-cell phenotypeen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0145-2126(02)00129-7en_US
dc.identifier.pmid12537975en_US
dc.identifier.scopuseid_2-s2.0-0037353325en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037353325&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue3en_US
dc.identifier.spage231en_US
dc.identifier.epage234en_US
dc.identifier.isiWOS:000181019600006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.issnl0145-2126-

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