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Article: Transferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
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TitleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
 
AuthorsMa, ESK1 2
Lam, KKY1
Chan, AYY1
Ha, SY1
Au, WY1
Chan, LC1
 
Issue Date2003
 
CitationHaematologica, 2003, v. 88 n. 3, p. 345-346 [How to Cite?]
 
AbstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.
 
ISSN0390-6078
2012 Impact Factor: 5.935
2012 SCImago Journal Rankings: 1.967
 
ISI Accession Number IDWOS:000181502900018
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMa, ESK
 
dc.contributor.authorLam, KKY
 
dc.contributor.authorChan, AYY
 
dc.contributor.authorHa, SY
 
dc.contributor.authorAu, WY
 
dc.contributor.authorChan, LC
 
dc.date.accessioned2012-05-29T06:12:13Z
 
dc.date.available2012-05-29T06:12:13Z
 
dc.date.issued2003
 
dc.description.abstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHaematologica, 2003, v. 88 n. 3, p. 345-346 [How to Cite?]
 
dc.identifier.epage346
 
dc.identifier.isiWOS:000181502900018
 
dc.identifier.issn0390-6078
2012 Impact Factor: 5.935
2012 SCImago Journal Rankings: 1.967
 
dc.identifier.issue3
 
dc.identifier.pmid12651274
 
dc.identifier.scopuseid_2-s2.0-0037346077
 
dc.identifier.spage345
 
dc.identifier.urihttp://hdl.handle.net/10722/148323
 
dc.identifier.volume88
 
dc.languageeng
 
dc.publisher.placeItaly
 
dc.relation.ispartofHaematologica
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBlood Transfusion
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshChina - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshIron Overload - Genetics
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Genetic
 
dc.subject.meshReceptors, Transferrin - Genetics
 
dc.subject.meshBeta-Thalassemia - Complications - Genetics - Therapy
 
dc.titleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
 
dc.typeArticle
 
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<contributor.author>Lam, KKY</contributor.author>
<contributor.author>Chan, AYY</contributor.author>
<contributor.author>Ha, SY</contributor.author>
<contributor.author>Au, WY</contributor.author>
<contributor.author>Chan, LC</contributor.author>
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<description.abstract>We investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent &#946;-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong