Article: Transferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
AuthorsMa, ESK1 2
Lam, KKY1
Chan, AYY1
Ha, SY1
Au, WY1
Chan, LC1
Issue Date2003
CitationHaematologica, 2003, v. 88 n. 3, p. 345-346 [How to Cite?]
AbstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.
ISSN0390-6078
2011 Impact Factor: 6.424
2011 SCImago Journal Rankings: 0.681
ISI Accession Number IDWOS:000181502900018
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMa, ESK
dc.contributor.authorLam, KKY
dc.contributor.authorChan, AYY
dc.contributor.authorHa, SY
dc.contributor.authorAu, WY
dc.contributor.authorChan, LC
dc.date.accessioned2012-05-29T06:12:13Z
dc.date.available2012-05-29T06:12:13Z
dc.date.issued2003
dc.description.abstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHaematologica, 2003, v. 88 n. 3, p. 345-346 [How to Cite?]
dc.identifier.epage346
dc.identifier.isiWOS:000181502900018
dc.identifier.issn0390-6078
2011 Impact Factor: 6.424
2011 SCImago Journal Rankings: 0.681
dc.identifier.issue3
dc.identifier.pmid12651274
dc.identifier.scopuseid_2-s2.0-0037346077
dc.identifier.spage345
dc.identifier.urihttp://hdl.handle.net/10722/148323
dc.identifier.volume88
dc.languageeng
dc.publisher.placeItaly
dc.relation.ispartofHaematologica
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBlood Transfusion
dc.subject.meshCase-Control Studies
dc.subject.meshChina - Epidemiology
dc.subject.meshHumans
dc.subject.meshIron Overload - Genetics
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Genetic
dc.subject.meshReceptors, Transferrin - Genetics
dc.subject.meshBeta-Thalassemia - Complications - Genetics - Therapy
dc.titleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong