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Article: Transferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia

TitleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermedia
Authors
Ma, ESKLam, KKYChan, AYYHa, SYAu, WYChan, LC
Keywordsβ-thalassemia intermedia
Genetic hemochromatosis
Iron overload
TFR2 polymorphism
Issue Date2003
Citation
Haematologica, 2003, v. 88 n. 3, p. 345-346 How to Cite?
AbstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.
Persistent Identifierhttp://hdl.handle.net/10722/148323
ISSN
0390-6078
2023 Impact Factor: 8.2
2023 SCImago Journal Rankings: 2.490
ISI Accession Number ID
WOS:000181502900018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMa, ESKen_US
dc.contributor.authorLam, KKYen_US
dc.contributor.authorChan, AYYen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:12:13Z-
dc.date.available2012-05-29T06:12:13Z-
dc.date.issued2003en_US
dc.identifier.citationHaematologica, 2003, v. 88 n. 3, p. 345-346en_US
dc.identifier.issn0390-6078en_US
dc.identifier.urihttp://hdl.handle.net/10722/148323-
dc.description.abstractWe investigated the relationship between transferrin receptor-2 (TFR2) polymorphisms, namely exon 5 1238M and IVS16 +251 CA deletion, and iron overload in 28 Chinese patients with transfusion-independent β-thalassemia intermedia. There were no significant differences in ferritin level and transferrin saturation between those with or without TFR2 polymorphisms. The number of patients with complications due to iron overload and on desferrioxamine therapy was also not increased among those with TFR2 polymorphisms. Other genetic determinant(s) that may affect the degree of iron overload should be sought in our thalassemia population.en_US
dc.languageengen_US
dc.relation.ispartofHaematologicaen_US
dc.subjectβ-thalassemia intermedia-
dc.subjectGenetic hemochromatosis-
dc.subjectIron overload-
dc.subjectTFR2 polymorphism-
dc.subject.meshAdulten_US
dc.subject.meshBlood Transfusionen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIron Overload - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Transferrin - Geneticsen_US
dc.subject.meshBeta-Thalassemia - Complications - Genetics - Therapyen_US
dc.titleTransferrin receptor-2 polymorphisms and iron overload in transfusion-independent β-thalassemia intermediaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12651274-
dc.identifier.scopuseid_2-s2.0-0037346077en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037346077&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume88en_US
dc.identifier.issue3en_US
dc.identifier.spage345en_US
dc.identifier.epage346en_US
dc.identifier.isiWOS:000181502900018-
dc.publisher.placeItalyen_US
dc.identifier.issnl0390-6078-

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