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Article: Consolidation therapy with autologous blood stem cell transplantation in a patient with primary plasma cell leukaemia

TitleConsolidation therapy with autologous blood stem cell transplantation in a patient with primary plasma cell leukaemia
Authors
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLH
Citation
Clinical And Laboratory Haematology, 2003, v. 25 n. 1, p. 55-58 How to Cite?
AbstractPrimary plasma cell leukaemia (PPCL) is a rare form of plasma cell dyscrasia. Conventional melphalan-based treatment is often ineffective, with a reported median survival of 2-7 months only. We report a 53-year-old man with PPCL who was treated with four cycles of combination chemotherapy including vincristine, adriamycin and dexamethasone that resulted in a good partial remission. High-dose melphalan 200 mg/m2 and autologous peripheral blood stem cell (PBSC) rescue was then given 6 months after diagnosis. Maintenance interferon-alpha was started 8 weeks after transplantation with good drug compliance. Complete remission was achieved and molecular remission was documented 11 months after autologous PBSC transplantation. In conclusion, high-dose therapy followed by autologous stem cell rescue is a feasible option for PPCL that can result in a reasonably sustained remission.
Persistent Identifierhttp://hdl.handle.net/10722/148322
ISSN
2008 Impact Factor: 1.304
2015 SCImago Journal Rankings: 0.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, YKen_US
dc.contributor.authorChan, CHen_US
dc.contributor.authorChen, YTen_US
dc.contributor.authorLau, SMen_US
dc.contributor.authorSo, CCen_US
dc.contributor.authorWong, KFen_US
dc.date.accessioned2012-05-29T06:12:12Z-
dc.date.available2012-05-29T06:12:12Z-
dc.date.issued2003en_US
dc.identifier.citationClinical And Laboratory Haematology, 2003, v. 25 n. 1, p. 55-58en_US
dc.identifier.issn0141-9854en_US
dc.identifier.urihttp://hdl.handle.net/10722/148322-
dc.description.abstractPrimary plasma cell leukaemia (PPCL) is a rare form of plasma cell dyscrasia. Conventional melphalan-based treatment is often ineffective, with a reported median survival of 2-7 months only. We report a 53-year-old man with PPCL who was treated with four cycles of combination chemotherapy including vincristine, adriamycin and dexamethasone that resulted in a good partial remission. High-dose melphalan 200 mg/m2 and autologous peripheral blood stem cell (PBSC) rescue was then given 6 months after diagnosis. Maintenance interferon-alpha was started 8 weeks after transplantation with good drug compliance. Complete remission was achieved and molecular remission was documented 11 months after autologous PBSC transplantation. In conclusion, high-dose therapy followed by autologous stem cell rescue is a feasible option for PPCL that can result in a reasonably sustained remission.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLHen_US
dc.relation.ispartofClinical and Laboratory Haematologyen_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Alpha - Therapeutic Useen_US
dc.subject.meshLeukemia, Plasma Cell - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeripheral Blood Stem Cell Transplantation - Methodsen_US
dc.subject.meshRemission Induction - Methodsen_US
dc.subject.meshTransplantation, Autologousen_US
dc.titleConsolidation therapy with autologous blood stem cell transplantation in a patient with primary plasma cell leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailSo, CC:scc@pathology.hku.hken_US
dc.identifier.authoritySo, CC=rp00391en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2257.2003.00485.xen_US
dc.identifier.pmid12542443-
dc.identifier.scopuseid_2-s2.0-0037330512en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037330512&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue1en_US
dc.identifier.spage55en_US
dc.identifier.epage58en_US
dc.identifier.isiWOS:000180600100009-
dc.publisher.placeUnited Kingdomen_US

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