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Article: Adenocarcinoma of the thymus: Report of two cases, including a previously undescribed mucinous subtype

TitleAdenocarcinoma of the thymus: Report of two cases, including a previously undescribed mucinous subtype
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 2003, v. 27 n. 1, p. 124-130 How to Cite?
AbstractWe report two cases of primary thymic adenocarcinoma, a very uncommon neoplasm with limited information in the literature. Both patients were men (age 15 and 39 years). The first case was a mucinous carcinoma, a subtype of adenocarcinoma not previously recognized in the thymus. It comprised islands and strips of mucin-rich tumor cells floating in large pools of extracellular mucin. There was transition of carcinomatous epithelium to the attenuated epithelium of a thymic cyst. Immunostaining for high molecular weight cytokeratin furthermore highlighted in one area negatively stained tumor islands wrapped by positively stained residual thymic medullary epithelium, suggesting in situ origin of the carcinoma from the thymic epithelium. The second case was a papillary carcinoma with high nuclear grade and many psammoma bodies. It showed strong immunoreactivity for CD5 and did not stain for CA-125 as well as thyroid, pulmonary, and mesothelial markers. The findings in this study therefore broaden the morphologic spectrum of thymic adenocarcinomas to include a mucinous subtype. Review of the literature indicates that thymic adenocarcinomas usually arise from thymic cyst or type A thymoma, and the clinical outcome is variable.
Persistent Identifierhttp://hdl.handle.net/10722/148317
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoi, WWLen_US
dc.contributor.authorLui, YHen_US
dc.contributor.authorLau, WHen_US
dc.contributor.authorCrowley, Pen_US
dc.contributor.authorKhan, Aen_US
dc.contributor.authorChan, JKCen_US
dc.date.accessioned2012-05-29T06:12:11Z-
dc.date.available2012-05-29T06:12:11Z-
dc.date.issued2003en_US
dc.identifier.citationAmerican Journal Of Surgical Pathology, 2003, v. 27 n. 1, p. 124-130en_US
dc.identifier.issn0147-5185en_US
dc.identifier.urihttp://hdl.handle.net/10722/148317-
dc.description.abstractWe report two cases of primary thymic adenocarcinoma, a very uncommon neoplasm with limited information in the literature. Both patients were men (age 15 and 39 years). The first case was a mucinous carcinoma, a subtype of adenocarcinoma not previously recognized in the thymus. It comprised islands and strips of mucin-rich tumor cells floating in large pools of extracellular mucin. There was transition of carcinomatous epithelium to the attenuated epithelium of a thymic cyst. Immunostaining for high molecular weight cytokeratin furthermore highlighted in one area negatively stained tumor islands wrapped by positively stained residual thymic medullary epithelium, suggesting in situ origin of the carcinoma from the thymic epithelium. The second case was a papillary carcinoma with high nuclear grade and many psammoma bodies. It showed strong immunoreactivity for CD5 and did not stain for CA-125 as well as thyroid, pulmonary, and mesothelial markers. The findings in this study therefore broaden the morphologic spectrum of thymic adenocarcinomas to include a mucinous subtype. Review of the literature indicates that thymic adenocarcinomas usually arise from thymic cyst or type A thymoma, and the clinical outcome is variable.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_US
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_US
dc.subject.meshAdenocarcinoma, Mucinous - Chemistry - Secondary - Therapyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Agents - Therapeutic Useen_US
dc.subject.meshCarcinoma, Papillary - Chemistry - Secondary - Therapyen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasm Proteins - Analysisen_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshRadiotherapyen_US
dc.subject.meshThymectomyen_US
dc.subject.meshThymus Neoplasms - Chemistry - Pathology - Therapyen_US
dc.subject.meshTumor Markers, Biological - Analysisen_US
dc.titleAdenocarcinoma of the thymus: Report of two cases, including a previously undescribed mucinous subtypeen_US
dc.typeArticleen_US
dc.identifier.emailChoi, WWL:wlchoi@pathology.hku.hken_US
dc.identifier.authorityChoi, WWL=rp00247en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00000478-200301000-00014en_US
dc.identifier.pmid12502935en_US
dc.identifier.scopuseid_2-s2.0-0037214207en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037214207&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.spage124en_US
dc.identifier.epage130en_US
dc.identifier.isiWOS:000180144000014-
dc.publisher.placeUnited Statesen_US

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