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Article: Cytologic findings of angioimmunoblastic T-cell lymphoma: Analysis of 16 fine-needle aspirates over a 9-year period

TitleCytologic findings of angioimmunoblastic T-cell lymphoma: Analysis of 16 fine-needle aspirates over a 9-year period
Authors
Issue Date2002
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2002, v. 96 n. 3, p. 166-173 How to Cite?
AbstractBACKGROUND. Peripheral T-cell lymphoma often represents an important diagnostic pitfall in fine-needle aspiration biopsy due to the heterogeneous cell population present. A classic example of this group is angioimmunoblastic T-cell lymphoma (AILD-T). The fine-needle aspiration cytology of this relatively well-defined histologic subtype of T-cell lymphoma is rarely described in the literature. METHODS. The authors reviewed 16 fine-needle aspirates of AILD-T from 9 patients in Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital, Hong Kong, over a 9-year period from early 1993 to mid-2001. The morphologic features seen in cytology smears and/or cell block sections were correlated with histologic and immunohistochemical findings of excisional biopsy specimens. RESULTS. The smears and cytospin preparations showed a heterogeneous population of hematolymphoid cells, including small lymphocytes; nondescript, medium-sized lymphoid cells; immunoblasts; plasma cells; eosinophils; and reticulum cells, including follicular dendritic cells. In general, tingible body macrophages were not identified. Conversely, follicular dendritic cells were discernible easily in most cases and sometimes were admixed intimately with lymphoid cells, forming dendritic cell-lymphocyte complexes. There also were large lymphoid tissue fragments containing a scaffold of arborizing small vessels. Pleomorphic cells with high mitotic activity or lymphoid cells with clear cytoplasm were not identified. The cell block sections often showed an intimate admixture of small lymphocytes, plasma cells, eosinophils, and reticulum cells amid a background of reticulin fibers. Lymphoid follicles with well-developed germinal centers were never found. The features seen in cytologic preparations were reminiscent of those seen in histologic sections of the corresponding lymph node excisional biopsies. CONCLUSIONS. Although ancillary investigative methods, including flow cytometry and molecular study, are of limited value in fine-needle aspiration cytology assessment of AILD-T due to the heterogeneous cell population present, recognition of the peculiar combination of cytologic features, especially in the right clinical setting, should provide a clue about the diagnosis. A high index of suspicion is essential to avoid a false negative diagnosis of reactive lymphadenopathy. © 2002 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/148314
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, WKen_US
dc.contributor.authorIp, Pen_US
dc.contributor.authorChoy, Cen_US
dc.contributor.authorCollins, RJen_US
dc.date.accessioned2012-05-29T06:12:10Z-
dc.date.available2012-05-29T06:12:10Z-
dc.date.issued2002en_US
dc.identifier.citationCancer, 2002, v. 96 n. 3, p. 166-173en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148314-
dc.description.abstractBACKGROUND. Peripheral T-cell lymphoma often represents an important diagnostic pitfall in fine-needle aspiration biopsy due to the heterogeneous cell population present. A classic example of this group is angioimmunoblastic T-cell lymphoma (AILD-T). The fine-needle aspiration cytology of this relatively well-defined histologic subtype of T-cell lymphoma is rarely described in the literature. METHODS. The authors reviewed 16 fine-needle aspirates of AILD-T from 9 patients in Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital, Hong Kong, over a 9-year period from early 1993 to mid-2001. The morphologic features seen in cytology smears and/or cell block sections were correlated with histologic and immunohistochemical findings of excisional biopsy specimens. RESULTS. The smears and cytospin preparations showed a heterogeneous population of hematolymphoid cells, including small lymphocytes; nondescript, medium-sized lymphoid cells; immunoblasts; plasma cells; eosinophils; and reticulum cells, including follicular dendritic cells. In general, tingible body macrophages were not identified. Conversely, follicular dendritic cells were discernible easily in most cases and sometimes were admixed intimately with lymphoid cells, forming dendritic cell-lymphocyte complexes. There also were large lymphoid tissue fragments containing a scaffold of arborizing small vessels. Pleomorphic cells with high mitotic activity or lymphoid cells with clear cytoplasm were not identified. The cell block sections often showed an intimate admixture of small lymphocytes, plasma cells, eosinophils, and reticulum cells amid a background of reticulin fibers. Lymphoid follicles with well-developed germinal centers were never found. The features seen in cytologic preparations were reminiscent of those seen in histologic sections of the corresponding lymph node excisional biopsies. CONCLUSIONS. Although ancillary investigative methods, including flow cytometry and molecular study, are of limited value in fine-needle aspiration cytology assessment of AILD-T due to the heterogeneous cell population present, recognition of the peculiar combination of cytologic features, especially in the right clinical setting, should provide a clue about the diagnosis. A high index of suspicion is essential to avoid a false negative diagnosis of reactive lymphadenopathy. © 2002 American Cancer Society.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoblastic Lymphadenopathy - Genetics - Pathologyen_US
dc.subject.meshLymphoma, T-Cell - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.titleCytologic findings of angioimmunoblastic T-cell lymphoma: Analysis of 16 fine-needle aspirates over a 9-year perioden_US
dc.typeArticleen_US
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_US
dc.identifier.authorityCollins, RJ=rp00251en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cncr.10617en_US
dc.identifier.pmid12115305-
dc.identifier.scopuseid_2-s2.0-0037172959en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037172959&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume96en_US
dc.identifier.issue3en_US
dc.identifier.spage166en_US
dc.identifier.epage173en_US
dc.identifier.isiWOS:000176272700008-
dc.publisher.placeUnited Statesen_US

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