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Article: Association of human papilomavirus type 58 variant with the risk of cervival cancer

TitleAssociation of human papilomavirus type 58 variant with the risk of cervival cancer
Authors
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/
Citation
Journal Of The National Cancer Institute, 2002, v. 94 n. 16, p. 1249-1253 How to Cite?
AbstractHuman papillomavirus (HPV) type 58 has been found to be prevalent among Chinese patients with cervical cancer. This study examined the oncogenic risk of HPV58 variants in Hong Kong, a southern part of China. Altogether, 1924 women were studied: 42.8% with a normal cervix, 16.2% with cervical intraepithelial neoplasia (CIN) I, 12.7% with CIN II, 20.8% with CIN III, and 7.6% with invasive cervical cancer (ICC). The overall prevalence of HPV58 was 11.4% (220) and increased statistically significantly with the severity of neoplasia (Ptrend<.001, Χ2 test for trend). Among HPV58-positive women, the occurrence of E7 632C→T (T20I) and E7 760G→A (G63S) variants (T20I/G63S) showed a positive trend of association with the severity of neoplasia (Ptrend<.001, Χ2 test for trend). HPV58 variants carrying these two substitutions showed an odds ratio (OR) for ICC of 26.79 (95% confidence interval = 10.14 to 74.72), and this OR was 6.9-fold higher than the ORs of variants without these substitutions. Patients with CIN III or ICC who were also infected with T20I/G63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P = .038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer.
Persistent Identifierhttp://hdl.handle.net/10722/148312
ISSN
2015 Impact Factor: 11.37
2015 SCImago Journal Rankings: 6.192
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, PKSen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorCheung, THen_US
dc.contributor.authorLi, WWHen_US
dc.contributor.authorLo, KWKen_US
dc.contributor.authorChan, MYMen_US
dc.contributor.authorCheung, JLKen_US
dc.contributor.authorCheng, AFen_US
dc.date.accessioned2012-05-29T06:12:09Z-
dc.date.available2012-05-29T06:12:09Z-
dc.date.issued2002en_US
dc.identifier.citationJournal Of The National Cancer Institute, 2002, v. 94 n. 16, p. 1249-1253en_US
dc.identifier.issn0027-8874en_US
dc.identifier.urihttp://hdl.handle.net/10722/148312-
dc.description.abstractHuman papillomavirus (HPV) type 58 has been found to be prevalent among Chinese patients with cervical cancer. This study examined the oncogenic risk of HPV58 variants in Hong Kong, a southern part of China. Altogether, 1924 women were studied: 42.8% with a normal cervix, 16.2% with cervical intraepithelial neoplasia (CIN) I, 12.7% with CIN II, 20.8% with CIN III, and 7.6% with invasive cervical cancer (ICC). The overall prevalence of HPV58 was 11.4% (220) and increased statistically significantly with the severity of neoplasia (Ptrend<.001, Χ2 test for trend). Among HPV58-positive women, the occurrence of E7 632C→T (T20I) and E7 760G→A (G63S) variants (T20I/G63S) showed a positive trend of association with the severity of neoplasia (Ptrend<.001, Χ2 test for trend). HPV58 variants carrying these two substitutions showed an odds ratio (OR) for ICC of 26.79 (95% confidence interval = 10.14 to 74.72), and this OR was 6.9-fold higher than the ORs of variants without these substitutions. Patients with CIN III or ICC who were also infected with T20I/G63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P = .038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/en_US
dc.relation.ispartofJournal of the National Cancer Instituteen_US
dc.subject.meshAdulten_US
dc.subject.meshAlanine - Geneticsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCervical Intraepithelial Neoplasia - Epidemiology - Virologyen_US
dc.subject.meshCysteine - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGlycine - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPapillomaviridae - Genetics - Isolation & Purificationen_US
dc.subject.meshPapillomavirus Infections - Complications - Epidemiology - Virologyen_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisken_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshThreonine - Geneticsen_US
dc.subject.meshTumor Virus Infections - Complications - Epidemiology - Virologyen_US
dc.subject.meshUterine Cervical Neoplasms - Epidemiology - Virologyen_US
dc.titleAssociation of human papilomavirus type 58 variant with the risk of cervival canceren_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12189229en_US
dc.identifier.scopuseid_2-s2.0-0037151253en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037151253&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume94en_US
dc.identifier.issue16en_US
dc.identifier.spage1249en_US
dc.identifier.epage1253en_US
dc.identifier.isiWOS:000177474200015-
dc.publisher.placeUnited Kingdomen_US

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