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Article: Two balanced and novel chromosomal translocations in myeloid malignancies: Characterization by multiplex fluorescence in situ hybridization

TitleTwo balanced and novel chromosomal translocations in myeloid malignancies: Characterization by multiplex fluorescence in situ hybridization
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2002, v. 139 n. 1, p. 52-56 How to Cite?
AbstractWe describe two novel chromosomal translocations in two cases of leukemia in which these translocations were further characterized as the sole acquired karyotypic abnormality by mutliplex fluorescence in situ hybridization (M-FISH). They comprised a case of acute myeloid leukemia with t(6;10)(q21;p12) and a case of chronic myelomonocytic leukemia with t(5;12)(q34;q24). To the best of our knowledge, these two balanced translocations are novel and are hitherto unrecognized in hematologic malignancies. While the clinical and pathogenic significance of these translocations remains to be defined, the present report illustrates that M-FISH technology contributes to the exclusion of subtle or cryptic translocations in sole karyotypic aberrations and the confirmation of novel chromosomal arrangements in neoplastic disorders. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148300
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorYip, SFen_US
dc.contributor.authorYeung, YMen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:12:05Z-
dc.date.available2012-05-29T06:12:05Z-
dc.date.issued2002en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2002, v. 139 n. 1, p. 52-56en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/148300-
dc.description.abstractWe describe two novel chromosomal translocations in two cases of leukemia in which these translocations were further characterized as the sole acquired karyotypic abnormality by mutliplex fluorescence in situ hybridization (M-FISH). They comprised a case of acute myeloid leukemia with t(6;10)(q21;p12) and a case of chronic myelomonocytic leukemia with t(5;12)(q34;q24). To the best of our knowledge, these two balanced translocations are novel and are hitherto unrecognized in hematologic malignancies. While the clinical and pathogenic significance of these translocations remains to be defined, the present report illustrates that M-FISH technology contributes to the exclusion of subtle or cryptic translocations in sole karyotypic aberrations and the confirmation of novel chromosomal arrangements in neoplastic disorders. © 2002 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 10en_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshChromosomes, Human, Pair 5en_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshLeukemia, Myelomonocytic, Chronic - Geneticsen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleTwo balanced and novel chromosomal translocations in myeloid malignancies: Characterization by multiplex fluorescence in situ hybridizationen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(02)00611-8en_US
dc.identifier.pmid12547159-
dc.identifier.scopuseid_2-s2.0-0036874762en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036874762&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume139en_US
dc.identifier.issue1en_US
dc.identifier.spage52en_US
dc.identifier.epage56en_US
dc.identifier.isiWOS:000180163700011-
dc.publisher.placeUnited Statesen_US

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