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Article: Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in Southern China

TitleHuman papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in Southern China
Authors
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2002, v. 186 n. 5, p. 696-700 How to Cite?
AbstractA case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. No increased risk was observed for the subclasses European variant and European 350G, which carry a higher risk for invasive cancer in some Western populations. The E7 N29S substitution, reported to have a higher risk in Korean women, was found equally distributed among normal and various degrees of neoplasia. The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world.
Persistent Identifierhttp://hdl.handle.net/10722/148294
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, PKSen_US
dc.contributor.authorChing, WLen_US
dc.contributor.authorTak, HCen_US
dc.contributor.authorLi, WWHen_US
dc.contributor.authorLo, KWKen_US
dc.contributor.authorChan, MYMen_US
dc.contributor.authorCheung, JLKen_US
dc.contributor.authorLi, YXen_US
dc.contributor.authorCheng, AFen_US
dc.date.accessioned2012-05-29T06:12:03Z-
dc.date.available2012-05-29T06:12:03Z-
dc.date.issued2002en_US
dc.identifier.citationJournal Of Infectious Diseases, 2002, v. 186 n. 5, p. 696-700en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/148294-
dc.description.abstractA case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. No increased risk was observed for the subclasses European variant and European 350G, which carry a higher risk for invasive cancer in some Western populations. The E7 N29S substitution, reported to have a higher risk in Korean women, was found equally distributed among normal and various degrees of neoplasia. The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOncogene Proteins, Viral - Geneticsen_US
dc.subject.meshPapillomaviridae - Classification - Geneticsen_US
dc.subject.meshPapillomavirus E7 Proteinsen_US
dc.subject.meshPapillomavirus Infections - Epidemiology - Virologyen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshTumor Virus Infections - Epidemiology - Virologyen_US
dc.subject.meshUterine Cervical Neoplasms - Epidemiology - Pathology - Virologyen_US
dc.titleHuman papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in Southern Chinaen_US
dc.typeArticleen_US
dc.identifier.emailChing, WL:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityChing, WL=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/342048en_US
dc.identifier.pmid12195358en_US
dc.identifier.scopuseid_2-s2.0-0036721266en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036721266&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume186en_US
dc.identifier.issue5en_US
dc.identifier.spage696en_US
dc.identifier.epage700en_US
dc.identifier.isiWOS:000177352900015-
dc.publisher.placeUnited Statesen_US

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