File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Nucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemia

TitleNucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemia
Authors
Issue Date2002
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 2002, v. 117 n. 2, p. 246-251 How to Cite?
AbstractChronic lymphoproliferative disorders sometimes can be difficult to classify. We report 4 cases characterized by large cells with distinct central nucleoli, reminiscent of prolymphocytic leukemia, but shown on further workup to represent mantle cell lymphoma. At initial examination, the patients had generalized lymphadenopathy, splenomegaly, and a leukemic blood picture. The peripheral blood showed many large cells with round to slightly irregular nuclei, single central nucleoli, and a fair amount of pale cytoplasm. The picture was not typical of prolymphocytic leukemia because of the presence of generalized lymphadenopathy and the large size of the circulating abnormal cells. Immunophenotypic study showed that the large lymphoid cells were CD5+ CD23-mature B cells with overexpression of cyclin D1, and cytogenetic study demonstrated the translocation t(11;14)(q13;q32) in 3 patients. Lymph node biopsy confirmed a diagnosis of mantle cell lymphoma, pleomorphic variant, in all 4 patients. This study documents the existence of an unusual leukemic form of mantle cell lymphoma with prominent nucleoli; the clinicopathologic features that distinguish it from other chronic lymphoproliferative disorders are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/148279
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorSo, CCen_US
dc.contributor.authorChan, JKCen_US
dc.date.accessioned2012-05-29T06:11:58Z-
dc.date.available2012-05-29T06:11:58Z-
dc.date.issued2002en_US
dc.identifier.citationAmerican Journal Of Clinical Pathology, 2002, v. 117 n. 2, p. 246-251en_US
dc.identifier.issn0002-9173en_US
dc.identifier.urihttp://hdl.handle.net/10722/148279-
dc.description.abstractChronic lymphoproliferative disorders sometimes can be difficult to classify. We report 4 cases characterized by large cells with distinct central nucleoli, reminiscent of prolymphocytic leukemia, but shown on further workup to represent mantle cell lymphoma. At initial examination, the patients had generalized lymphadenopathy, splenomegaly, and a leukemic blood picture. The peripheral blood showed many large cells with round to slightly irregular nuclei, single central nucleoli, and a fair amount of pale cytoplasm. The picture was not typical of prolymphocytic leukemia because of the presence of generalized lymphadenopathy and the large size of the circulating abnormal cells. Immunophenotypic study showed that the large lymphoid cells were CD5+ CD23-mature B cells with overexpression of cyclin D1, and cytogenetic study demonstrated the translocation t(11;14)(q13;q32) in 3 patients. Lymph node biopsy confirmed a diagnosis of mantle cell lymphoma, pleomorphic variant, in all 4 patients. This study documents the existence of an unusual leukemic form of mantle cell lymphoma with prominent nucleoli; the clinicopathologic features that distinguish it from other chronic lymphoproliferative disorders are discussed.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_US
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Cd5 - Biosynthesisen_US
dc.subject.meshBone Marrowen_US
dc.subject.meshCell Nucleolus - Pathologyen_US
dc.subject.meshCyclin D1 - Biosynthesisen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshLeukemia, Hairy Cell - Diagnosisen_US
dc.subject.meshLeukemia, Prolymphocytic - Diagnosisen_US
dc.subject.meshLymph Nodes - Pathologyen_US
dc.subject.meshLymphatic Diseases - Etiology - Pathologyen_US
dc.subject.meshLymphoma, Mantle-Cell - Classification - Diagnosis - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshSplenomegaly - Etiologyen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleNucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailSo, CC:scc@pathology.hku.hken_US
dc.identifier.authoritySo, CC=rp00391en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1309/4LTE-JHNC-C8RC-FGWLen_US
dc.identifier.pmid11865846en_US
dc.identifier.scopuseid_2-s2.0-0036325532en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036325532&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue2en_US
dc.identifier.spage246en_US
dc.identifier.epage251en_US
dc.identifier.isiWOS:000173661600010-
dc.publisher.placeUnited Statesen_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats