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Article: The ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia

TitleThe ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia
Authors
Ma, ESKChan, AYYSau, YHChan, GCFWing, YALi, CC
Keywordsα-thalassemia
β-thalassemia
Genotype-phenotype correlation
SEA deletion
Thalassemia intermedia
Issue Date2002
Citation
Haematologica, 2002, v. 87 n. 4, p. 443-444 How to Cite?
AbstractAmong 108 Chinese patients who showed two β-thalassemia alleles on genotyping, five out of six β0/β0-thalassemia patients who co-inherited the SEA deletion showed β-thalassemia major phenotype, whereas all five patients with β0/β+-thalassemia and concurrent SEA deletion showed β-thalassemia intermedia phenotype. The SEA deletion therefore ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia.
Persistent Identifierhttp://hdl.handle.net/10722/148276
ISSN
0390-6078
2023 Impact Factor: 8.2
2023 SCImago Journal Rankings: 2.490
ISI Accession Number ID
WOS:000174775400017
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorChan, AYYen_HK
dc.contributor.authorSau, YHen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorWing, YAen_HK
dc.contributor.authorLi, CCen_HK
dc.date.accessioned2012-05-29T06:11:57Z-
dc.date.available2012-05-29T06:11:57Z-
dc.date.issued2002en_HK
dc.identifier.citationHaematologica, 2002, v. 87 n. 4, p. 443-444en_HK
dc.identifier.issn0390-6078en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148276-
dc.description.abstractAmong 108 Chinese patients who showed two β-thalassemia alleles on genotyping, five out of six β0/β0-thalassemia patients who co-inherited the SEA deletion showed β-thalassemia major phenotype, whereas all five patients with β0/β+-thalassemia and concurrent SEA deletion showed β-thalassemia intermedia phenotype. The SEA deletion therefore ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia.en_HK
dc.languageengen_US
dc.relation.ispartofHaematologicaen_HK
dc.subjectα-thalassemiaen_HK
dc.subjectβ-thalassemiaen_HK
dc.subjectGenotype-phenotype correlationen_HK
dc.subjectSEA deletionen_HK
dc.subjectThalassemia intermediaen_HK
dc.subject.meshAge Of Onseten_US
dc.subject.meshAllelesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChina - Epidemiology - Ethnologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshPhenotypeen_US
dc.subject.meshSequence Deletion - Physiologyen_US
dc.subject.meshAlpha-Thalassemia - Geneticsen_US
dc.subject.meshBeta-Thalassemia - Geneticsen_US
dc.titleThe ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemiaen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLi, CC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLi, CC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11940490-
dc.identifier.scopuseid_2-s2.0-0036213269en_HK
dc.identifier.hkuros66014-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036213269&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume87en_HK
dc.identifier.issue4en_HK
dc.identifier.spage443en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:000174775400017-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridChan, AYY=7403168182en_HK
dc.identifier.scopusauthoridSau, YH=7801690693en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridWing, YA=7004821181en_HK
dc.identifier.scopusauthoridLi, CC=7403540707en_HK
dc.identifier.issnl0390-6078-

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