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Article: The ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia
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TitleThe ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia
 
AuthorsMa, ESK1
Chan, AYY1
Sau, YH1
Chan, GCF1
Wing, YA1
Li, CC1
 
Keywordsα-thalassemia
β-thalassemia
Genotype-phenotype correlation
SEA deletion
Thalassemia intermedia
 
Issue Date2002
 
CitationHaematologica, 2002, v. 87 n. 4, p. 443-444 [How to Cite?]
 
AbstractAmong 108 Chinese patients who showed two β-thalassemia alleles on genotyping, five out of six β0/β0-thalassemia patients who co-inherited the SEA deletion showed β-thalassemia major phenotype, whereas all five patients with β0/β+-thalassemia and concurrent SEA deletion showed β-thalassemia intermedia phenotype. The SEA deletion therefore ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia.
 
ISSN0390-6078
2013 Impact Factor: 5.868
 
ISI Accession Number IDWOS:000174775400017
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMa, ESK
 
dc.contributor.authorChan, AYY
 
dc.contributor.authorSau, YH
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorWing, YA
 
dc.contributor.authorLi, CC
 
dc.date.accessioned2012-05-29T06:11:57Z
 
dc.date.available2012-05-29T06:11:57Z
 
dc.date.issued2002
 
dc.description.abstractAmong 108 Chinese patients who showed two β-thalassemia alleles on genotyping, five out of six β0/β0-thalassemia patients who co-inherited the SEA deletion showed β-thalassemia major phenotype, whereas all five patients with β0/β+-thalassemia and concurrent SEA deletion showed β-thalassemia intermedia phenotype. The SEA deletion therefore ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHaematologica, 2002, v. 87 n. 4, p. 443-444 [How to Cite?]
 
dc.identifier.epage444
 
dc.identifier.hkuros66014
 
dc.identifier.isiWOS:000174775400017
 
dc.identifier.issn0390-6078
2013 Impact Factor: 5.868
 
dc.identifier.issue4
 
dc.identifier.pmid11940490
 
dc.identifier.scopuseid_2-s2.0-0036213269
 
dc.identifier.spage443
 
dc.identifier.urihttp://hdl.handle.net/10722/148276
 
dc.identifier.volume87
 
dc.languageeng
 
dc.publisher.placeItaly
 
dc.relation.ispartofHaematologica
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAge Of Onset
 
dc.subject.meshAlleles
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshChina - Epidemiology - Ethnology
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshPhenotype
 
dc.subject.meshSequence Deletion - Physiology
 
dc.subject.meshAlpha-Thalassemia - Genetics
 
dc.subject.meshBeta-Thalassemia - Genetics
 
dc.subjectα-thalassemia
 
dc.subjectβ-thalassemia
 
dc.subjectGenotype-phenotype correlation
 
dc.subjectSEA deletion
 
dc.subjectThalassemia intermedia
 
dc.titleThe ( - SEA) α-thalassemia (SEA) deletion ameliorates the clinical phenotype of β0/β+ but not necessarily that of β0/β0 thalassemia
 
dc.typeArticle
 
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<contributor.author>Li, CC</contributor.author>
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Author Affiliations
  1. The University of Hong Kong